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- W3008326844 abstract "Hyphenating liquid chromatography (LC) with mass spectrometry (MS) has produced an extremely powerful range of analytical tools for the qualitative and quantitative analysis of complex samples. LC-MS combines separation power with high sensitivity and it provides detailed information on compound identity. Many obstacles had to be overcome before LC-MS instruments became widely applicable and highly successful. The greatest breakthrough has come from atmospheric-pressure ionization techniques, in which the ionization preceded the vacuum stage. Robust and reliable systems have emerged and the range of analytes that are amenable to LC-MS has been greatly expanded. A broad spectrum of LC setups can be used, ranging from conventional (mL/min) to nanoflow (< 1 mL/min) systems, together with the full range of MS analysers. LC-MS/MS and LC-MSn techniques are commonly employed, both for qualitative and quantitative purposes." @default.
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- W3008326844 date "2020-01-01" @default.
- W3008326844 modified "2023-10-01" @default.
- W3008326844 title "History of liquid chromatography—mass spectrometry couplings" @default.
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- W3008326844 doi "https://doi.org/10.1016/b978-0-12-809638-3.00007-7" @default.
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