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- W3008337271 endingPage "389" @default.
- W3008337271 startingPage "377" @default.
- W3008337271 abstract "Chemotherapy-induced cardiovascular toxicity (CICT) is a well-established risk for cancer survivors and causes diseases such as heart failure, arrhythmia, vascular dysfunction, and atherosclerosis. As our knowledge of the precise cardiovascular risks of each chemotherapy agent has improved, it has become clear that genomics is one of the most influential predictors of which patients will experience cardiovascular toxicity. Most recently, GWAS-led, top-down approaches have identified novel genetic variants and their related genes that are statistically related to CICT. Importantly, the advent of human-induced pluripotent stem cell (hiPSC) models provides a system to experimentally test the effect of these genomic findings in vitro, query the underlying mechanisms, and develop novel strategies to mitigate the cardiovascular toxicity liabilities due to these mechanisms. Here we review the cardiovascular toxicities of chemotherapy drugs, discuss how these can be modeled in vitro, and suggest how these models can be used to validate genetic variants that predispose patients to these effects." @default.
- W3008337271 created "2020-03-06" @default.
- W3008337271 creator A5004361832 @default.
- W3008337271 creator A5041314351 @default.
- W3008337271 creator A5091649334 @default.
- W3008337271 date "2020-02-20" @default.
- W3008337271 modified "2023-09-27" @default.
- W3008337271 title "Human In Vitro Models for Assessing the Genomic Basis of Chemotherapy-Induced Cardiovascular Toxicity" @default.
- W3008337271 cites W1492360552 @default.
- W3008337271 cites W1512691487 @default.
- W3008337271 cites W1563180177 @default.
- W3008337271 cites W1820605760 @default.
- W3008337271 cites W1828224642 @default.
- W3008337271 cites W1939978733 @default.
- W3008337271 cites W1963668689 @default.
- W3008337271 cites W1963699880 @default.
- W3008337271 cites W1975300821 @default.
- W3008337271 cites W1979059719 @default.
- W3008337271 cites W1988152669 @default.
- W3008337271 cites W1991994331 @default.
- W3008337271 cites W1992656581 @default.
- W3008337271 cites W1998190377 @default.
- W3008337271 cites W2010687863 @default.
- W3008337271 cites W2014432477 @default.
- W3008337271 cites W2014606320 @default.
- W3008337271 cites W2023570397 @default.
- W3008337271 cites W2024751402 @default.
- W3008337271 cites W2026117523 @default.
- W3008337271 cites W2027856133 @default.
- W3008337271 cites W2033896075 @default.
- W3008337271 cites W2034209291 @default.
- W3008337271 cites W2043416888 @default.
- W3008337271 cites W2045089711 @default.
- W3008337271 cites W2045570587 @default.
- W3008337271 cites W2045820133 @default.
- W3008337271 cites W2051357882 @default.
- W3008337271 cites W2054465152 @default.
- W3008337271 cites W2064437259 @default.
- W3008337271 cites W2069435392 @default.
- W3008337271 cites W2072524978 @default.
- W3008337271 cites W2073616129 @default.
- W3008337271 cites W2084790690 @default.
- W3008337271 cites W2085459418 @default.
- W3008337271 cites W2103273190 @default.
- W3008337271 cites W2106631668 @default.
- W3008337271 cites W2106883129 @default.
- W3008337271 cites W2111426313 @default.
- W3008337271 cites W2112087830 @default.
- W3008337271 cites W2112559529 @default.
- W3008337271 cites W2115796512 @default.
- W3008337271 cites W2119443549 @default.
- W3008337271 cites W2127856462 @default.
- W3008337271 cites W2129933927 @default.
- W3008337271 cites W2133493757 @default.
- W3008337271 cites W2134189998 @default.
- W3008337271 cites W2134766290 @default.
- W3008337271 cites W2140182328 @default.
- W3008337271 cites W2146739251 @default.
- W3008337271 cites W2152922562 @default.
- W3008337271 cites W2160165070 @default.
- W3008337271 cites W2164271393 @default.
- W3008337271 cites W2175703301 @default.
- W3008337271 cites W2176157215 @default.
- W3008337271 cites W2181241483 @default.
- W3008337271 cites W2224765732 @default.
- W3008337271 cites W2227148039 @default.
- W3008337271 cites W2318922603 @default.
- W3008337271 cites W2330366426 @default.
- W3008337271 cites W2338021849 @default.
- W3008337271 cites W2343360984 @default.
- W3008337271 cites W2346631874 @default.
- W3008337271 cites W2466250207 @default.
- W3008337271 cites W2470078220 @default.
- W3008337271 cites W2511645685 @default.
- W3008337271 cites W2533632435 @default.
- W3008337271 cites W2538466402 @default.
- W3008337271 cites W2544855682 @default.
- W3008337271 cites W2568205606 @default.
- W3008337271 cites W2587938050 @default.
- W3008337271 cites W2593518655 @default.
- W3008337271 cites W2597137467 @default.
- W3008337271 cites W2604490956 @default.
- W3008337271 cites W2604964915 @default.
- W3008337271 cites W2616699005 @default.
- W3008337271 cites W2724823023 @default.
- W3008337271 cites W2728836125 @default.
- W3008337271 cites W2740029254 @default.
- W3008337271 cites W2742481253 @default.
- W3008337271 cites W2742550673 @default.
- W3008337271 cites W2745112353 @default.
- W3008337271 cites W2746747500 @default.
- W3008337271 cites W2760886327 @default.
- W3008337271 cites W2766094435 @default.
- W3008337271 cites W2772682222 @default.
- W3008337271 cites W2774386502 @default.
- W3008337271 cites W2781642135 @default.
- W3008337271 cites W2793069147 @default.
- W3008337271 cites W2797440507 @default.