Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008481058> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W3008481058 abstract "The general focus of this thesis was to develop experimental models for a type of chronic heart failure in which the left ventricle of the heart must generate higher pressure to pump blood into the aorta (such as aortic valve stenosis and high blood pressure induced heart failure). These established cell and animal models make it possible in the future to (i) further investigate underlying mechanisms that cause the onset of heart failure, and to (ii) test metabolic interventions aimed at the prevention / treatment of structural (heart muscle thickening) and functional changes (contractile force) of the heart. The results imply that changes in fuel consumption precede heart muscle thickening and a decrease in contractile force of the heart muscle. These results confirm the hypothesis that metabolic interventions can be useful in combating and / or treating heart muscle thickening. The first metabolic interventions (aimed at reducing sugar intake) forced heart muscle cells to make more use of fats as fuel, resulting in an improved contractile force. These findings complement the current knowledge regarding the pathophysiology that underlies the onset of heart failure, and can therefore contribute to finding new potential targets." @default.
- W3008481058 created "2020-03-06" @default.
- W3008481058 creator A5069288350 @default.
- W3008481058 date "2020-02-17" @default.
- W3008481058 modified "2023-09-23" @default.
- W3008481058 title "Metabolic phenotyping of the pressure-overloaded heart" @default.
- W3008481058 doi "https://doi.org/10.26481/dis.20200124ig" @default.
- W3008481058 hasPublicationYear "2020" @default.
- W3008481058 type Work @default.
- W3008481058 sameAs 3008481058 @default.
- W3008481058 citedByCount "0" @default.
- W3008481058 crossrefType "dissertation" @default.
- W3008481058 hasAuthorship W3008481058A5069288350 @default.
- W3008481058 hasBestOaLocation W30084810581 @default.
- W3008481058 hasConcept C126322002 @default.
- W3008481058 hasConcept C164705383 @default.
- W3008481058 hasConcept C2776229121 @default.
- W3008481058 hasConcept C2778198053 @default.
- W3008481058 hasConcept C2778271984 @default.
- W3008481058 hasConcept C2778921608 @default.
- W3008481058 hasConcept C3018791406 @default.
- W3008481058 hasConcept C71924100 @default.
- W3008481058 hasConcept C72859922 @default.
- W3008481058 hasConcept C84393581 @default.
- W3008481058 hasConceptScore W3008481058C126322002 @default.
- W3008481058 hasConceptScore W3008481058C164705383 @default.
- W3008481058 hasConceptScore W3008481058C2776229121 @default.
- W3008481058 hasConceptScore W3008481058C2778198053 @default.
- W3008481058 hasConceptScore W3008481058C2778271984 @default.
- W3008481058 hasConceptScore W3008481058C2778921608 @default.
- W3008481058 hasConceptScore W3008481058C3018791406 @default.
- W3008481058 hasConceptScore W3008481058C71924100 @default.
- W3008481058 hasConceptScore W3008481058C72859922 @default.
- W3008481058 hasConceptScore W3008481058C84393581 @default.
- W3008481058 hasLocation W30084810581 @default.
- W3008481058 hasLocation W30084810582 @default.
- W3008481058 hasLocation W30084810583 @default.
- W3008481058 hasLocation W30084810584 @default.
- W3008481058 hasLocation W30084810585 @default.
- W3008481058 hasLocation W30084810586 @default.
- W3008481058 hasOpenAccess W3008481058 @default.
- W3008481058 hasPrimaryLocation W30084810581 @default.
- W3008481058 hasRelatedWork W1494970897 @default.
- W3008481058 hasRelatedWork W168237665 @default.
- W3008481058 hasRelatedWork W170229091 @default.
- W3008481058 hasRelatedWork W1977865280 @default.
- W3008481058 hasRelatedWork W2024966637 @default.
- W3008481058 hasRelatedWork W2061387642 @default.
- W3008481058 hasRelatedWork W2077842562 @default.
- W3008481058 hasRelatedWork W2117620339 @default.
- W3008481058 hasRelatedWork W2133441890 @default.
- W3008481058 hasRelatedWork W2169190460 @default.
- W3008481058 hasRelatedWork W2217998473 @default.
- W3008481058 hasRelatedWork W2286753725 @default.
- W3008481058 hasRelatedWork W2546972033 @default.
- W3008481058 hasRelatedWork W2617647564 @default.
- W3008481058 hasRelatedWork W2787908679 @default.
- W3008481058 hasRelatedWork W3264470 @default.
- W3008481058 hasRelatedWork W595959256 @default.
- W3008481058 hasRelatedWork W7341054 @default.
- W3008481058 hasRelatedWork W77155751 @default.
- W3008481058 hasRelatedWork W1989494072 @default.
- W3008481058 isParatext "false" @default.
- W3008481058 isRetracted "false" @default.
- W3008481058 magId "3008481058" @default.
- W3008481058 workType "dissertation" @default.