Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008483803> ?p ?o ?g. }
- W3008483803 endingPage "4765" @default.
- W3008483803 startingPage "4707" @default.
- W3008483803 abstract "The fundamental roles that peptides and proteins play in today's biology makes it almost indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to extrapolate back from extant biology to the prebiotic world, one must acknowledge the critical importance that interconnected molecular networks, likely with peptides as key components, would have played in life's origin. In this review, we summarize chemical processes involving peptides that could have contributed to early chemical evolution, with an emphasis on molecular interactions between peptides and other classes of organic molecules. We first summarize mechanisms by which amino acids and similar building blocks could have been produced and elaborated into proto-peptides. Next, non-covalent interactions of peptides with other peptides as well as with nucleic acids, lipids, carbohydrates, metal ions, and aromatic molecules are discussed in relation to the possible roles of such interactions in chemical evolution of structure and function. Finally, we describe research involving structural alternatives to peptides and covalent adducts between amino acids/peptides and other classes of molecules. We propose that ample future breakthroughs in origin-of-life chemistry will stem from investigations of interconnected chemical systems in which synergistic interactions between different classes of molecules emerge." @default.
- W3008483803 created "2020-03-06" @default.
- W3008483803 creator A5010678427 @default.
- W3008483803 creator A5043173727 @default.
- W3008483803 creator A5071270025 @default.
- W3008483803 creator A5074904216 @default.
- W3008483803 date "2020-02-26" @default.
- W3008483803 modified "2023-10-11" @default.
- W3008483803 title "Prebiotic Peptides: Molecular Hubs in the Origin of Life" @default.
- W3008483803 cites W1026445185 @default.
- W3008483803 cites W1075582021 @default.
- W3008483803 cites W1130563070 @default.
- W3008483803 cites W127870200 @default.
- W3008483803 cites W146609594 @default.
- W3008483803 cites W1490929353 @default.
- W3008483803 cites W1501796863 @default.
- W3008483803 cites W1511276416 @default.
- W3008483803 cites W1517465250 @default.
- W3008483803 cites W1525122828 @default.
- W3008483803 cites W1529684117 @default.
- W3008483803 cites W1541628860 @default.
- W3008483803 cites W1544360397 @default.
- W3008483803 cites W1548493774 @default.
- W3008483803 cites W1549577203 @default.
- W3008483803 cites W1551903256 @default.
- W3008483803 cites W1563805134 @default.
- W3008483803 cites W1568335494 @default.
- W3008483803 cites W1580124635 @default.
- W3008483803 cites W1585551207 @default.
- W3008483803 cites W1592869829 @default.
- W3008483803 cites W1593363102 @default.
- W3008483803 cites W1603607205 @default.
- W3008483803 cites W1609487790 @default.
- W3008483803 cites W1631795182 @default.
- W3008483803 cites W163225201 @default.
- W3008483803 cites W1638884317 @default.
- W3008483803 cites W1645032347 @default.
- W3008483803 cites W173701656 @default.
- W3008483803 cites W1761469524 @default.
- W3008483803 cites W1795161332 @default.
- W3008483803 cites W1830480887 @default.
- W3008483803 cites W1865631169 @default.
- W3008483803 cites W187701066 @default.
- W3008483803 cites W1877641682 @default.
- W3008483803 cites W1877959862 @default.
- W3008483803 cites W1892192544 @default.
- W3008483803 cites W1901829484 @default.
- W3008483803 cites W1927299328 @default.
- W3008483803 cites W19273848 @default.
- W3008483803 cites W1928629620 @default.
- W3008483803 cites W1929669830 @default.
- W3008483803 cites W1930369548 @default.
- W3008483803 cites W1935356375 @default.
- W3008483803 cites W1963561208 @default.
- W3008483803 cites W1963673259 @default.
- W3008483803 cites W1963738030 @default.
- W3008483803 cites W1963744953 @default.
- W3008483803 cites W1964186793 @default.
- W3008483803 cites W1964277748 @default.
- W3008483803 cites W1964291083 @default.
- W3008483803 cites W1964743963 @default.
- W3008483803 cites W1965061544 @default.
- W3008483803 cites W1965378784 @default.
- W3008483803 cites W1966080493 @default.
- W3008483803 cites W1966424887 @default.
- W3008483803 cites W1967700370 @default.
- W3008483803 cites W1967733770 @default.
- W3008483803 cites W1967958557 @default.
- W3008483803 cites W1968032235 @default.
- W3008483803 cites W1968077397 @default.
- W3008483803 cites W1969008792 @default.
- W3008483803 cites W1969583827 @default.
- W3008483803 cites W1969990203 @default.
- W3008483803 cites W1970096428 @default.
- W3008483803 cites W1970155923 @default.
- W3008483803 cites W1970330502 @default.
- W3008483803 cites W1970381306 @default.
- W3008483803 cites W1970454669 @default.
- W3008483803 cites W1970577444 @default.
- W3008483803 cites W1970805572 @default.
- W3008483803 cites W1970919857 @default.
- W3008483803 cites W1970977492 @default.
- W3008483803 cites W1971331214 @default.
- W3008483803 cites W1971948710 @default.
- W3008483803 cites W1971949174 @default.
- W3008483803 cites W1972624327 @default.
- W3008483803 cites W1972798923 @default.
- W3008483803 cites W1972987593 @default.
- W3008483803 cites W1973697232 @default.
- W3008483803 cites W1973897761 @default.
- W3008483803 cites W1974187431 @default.
- W3008483803 cites W1974374321 @default.
- W3008483803 cites W1975069045 @default.
- W3008483803 cites W1975275338 @default.
- W3008483803 cites W1975451609 @default.
- W3008483803 cites W1975667107 @default.
- W3008483803 cites W1975995173 @default.
- W3008483803 cites W1976073965 @default.