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• W3008492890 abstract "Abstract Malignant transformation and progression in cancer is associated with the altered expression of multiple miRNAs, which are considered as post-transcriptional regulators of genes participating in various cellular processes. Although, it has been proposed that miR-23b-3p acts as a tumor suppressor in cervical cancer (CC), not all the pathways through which it alters the cellular processes have been described. The present study examines whether miR-23b-3p directly represses the c-Met expression and that consequently modifies the proliferation, migration and invasion of C33A and CaSki cells. c-Met has five microRNA response elements (MREs) for miR-23b-3p in the 3′-UTR region. The ectopic overexpression of miR-23b-3p significantly reduces c-Met expression in C33A and CaSki cells. The overexpression of miR-23b-3p reduces proliferation, migration and invasion of CaSki cells and the proliferation and invasion in C33A cells. In CaSki cells, the activation of Gab1 and Fak, downstream of c-Met, is reduced in response to the overexpression of miR-23b-3p. Together, the results in the present study indicate that miR-23b-3p is a tumor suppressor that modulates the progression of CC via post-transcriptional regulation of the c-Met oncogene." @default.
• W3008492890 created "2020-03-06" @default.
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• W3008492890 date "2020-02-24" @default.
• W3008492890 modified "2023-10-18" @default.
• W3008492890 title "MiR-23b-3p reduces the proliferation, migration and invasion of cervical cancer cell lines via the reduction of c-Met expression" @default.
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• W3008492890 doi "https://doi.org/10.1038/s41598-020-60143-x" @default.
• W3008492890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7039958" @default.
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• W3008492890 hasPublicationYear "2020" @default.
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