Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008532904> ?p ?o ?g. }
- W3008532904 endingPage "105" @default.
- W3008532904 startingPage "95" @default.
- W3008532904 abstract "Notch signaling is an evolutionarily conserved pathway that plays a central role in a number of cellular events during metazoan development. Due to its involvement in numerous developmental events, Notch signaling requires tight spatial and temporal regulation. Deltex is a cytoplasmic protein that physically binds to the Notch and regulates its signaling activity in a context-dependent manner. However, the biology of Deltex in regulation of Notch signaling is not well explored. For a better understanding of Deltex activity in the regulatory circuit of Notch pathway, a co-IP-based screening was performed. Hrp48, an RNA-binding protein, was identified as an interacting partner of Deltex in that screening. Interaction of these two proteins seemed to regulate the Notch signaling outcome in the epithelial tissue. Additionally, it was found that coexpression of Deltex and Hrp48 can lead to cell death as well as JNK activation. Considering the fact of well conserved nature of Notch as well as both of these two proteins, namely, Hrp48 and Deltex, this interaction can be helpful to understand the regulation of Notch signaling both in development and disease condition." @default.
- W3008532904 created "2020-03-06" @default.
- W3008532904 creator A5037055842 @default.
- W3008532904 creator A5037983336 @default.
- W3008532904 creator A5040625048 @default.
- W3008532904 date "2020-01-01" @default.
- W3008532904 modified "2023-10-09" @default.
- W3008532904 title "Regulation of Notch Signaling in Drosophila melanogaster: The Role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex" @default.
- W3008532904 cites W1482735025 @default.
- W3008532904 cites W1595935608 @default.
- W3008532904 cites W1655397332 @default.
- W3008532904 cites W1675105744 @default.
- W3008532904 cites W1824693654 @default.
- W3008532904 cites W1858921550 @default.
- W3008532904 cites W1897178313 @default.
- W3008532904 cites W1933096416 @default.
- W3008532904 cites W1964445614 @default.
- W3008532904 cites W1966735021 @default.
- W3008532904 cites W1966974824 @default.
- W3008532904 cites W1967042670 @default.
- W3008532904 cites W1972168412 @default.
- W3008532904 cites W1973763480 @default.
- W3008532904 cites W1977661665 @default.
- W3008532904 cites W1977962361 @default.
- W3008532904 cites W1981116235 @default.
- W3008532904 cites W1984475127 @default.
- W3008532904 cites W1984610351 @default.
- W3008532904 cites W1990543875 @default.
- W3008532904 cites W1995786503 @default.
- W3008532904 cites W1997801717 @default.
- W3008532904 cites W1999615839 @default.
- W3008532904 cites W2007280697 @default.
- W3008532904 cites W2007898372 @default.
- W3008532904 cites W2007904774 @default.
- W3008532904 cites W2017423460 @default.
- W3008532904 cites W2022798729 @default.
- W3008532904 cites W2025269346 @default.
- W3008532904 cites W2025983897 @default.
- W3008532904 cites W2032603175 @default.
- W3008532904 cites W2037621262 @default.
- W3008532904 cites W2039980882 @default.
- W3008532904 cites W2040140203 @default.
- W3008532904 cites W2044526956 @default.
- W3008532904 cites W2045165927 @default.
- W3008532904 cites W2050645840 @default.
- W3008532904 cites W2053890552 @default.
- W3008532904 cites W2073146686 @default.
- W3008532904 cites W2074159015 @default.
- W3008532904 cites W2074584250 @default.
- W3008532904 cites W2082195162 @default.
- W3008532904 cites W2083425643 @default.
- W3008532904 cites W2083489721 @default.
- W3008532904 cites W2084345817 @default.
- W3008532904 cites W2087672655 @default.
- W3008532904 cites W2090255118 @default.
- W3008532904 cites W2098268993 @default.
- W3008532904 cites W2107014746 @default.
- W3008532904 cites W2110643873 @default.
- W3008532904 cites W2111128124 @default.
- W3008532904 cites W2111341494 @default.
- W3008532904 cites W2115420164 @default.
- W3008532904 cites W2117789426 @default.
- W3008532904 cites W2119838887 @default.
- W3008532904 cites W2121790667 @default.
- W3008532904 cites W2133943800 @default.
- W3008532904 cites W2137688565 @default.
- W3008532904 cites W2138957442 @default.
- W3008532904 cites W2140239718 @default.
- W3008532904 cites W2149008219 @default.
- W3008532904 cites W2149649384 @default.
- W3008532904 cites W2154861644 @default.
- W3008532904 cites W2156852003 @default.
- W3008532904 cites W2160243151 @default.
- W3008532904 cites W2160362993 @default.
- W3008532904 cites W2161909222 @default.
- W3008532904 cites W2161924138 @default.
- W3008532904 cites W2166225419 @default.
- W3008532904 cites W2186370879 @default.
- W3008532904 cites W2186899998 @default.
- W3008532904 cites W2189148194 @default.
- W3008532904 cites W2235387468 @default.
- W3008532904 cites W2586723043 @default.
- W3008532904 cites W2606920814 @default.
- W3008532904 cites W2615263304 @default.
- W3008532904 cites W2619571880 @default.
- W3008532904 cites W2795955145 @default.
- W3008532904 cites W2803252994 @default.
- W3008532904 cites W2891879622 @default.
- W3008532904 cites W2893590138 @default.
- W3008532904 cites W2947925034 @default.
- W3008532904 cites W4210958860 @default.
- W3008532904 doi "https://doi.org/10.1007/978-3-030-36422-9_7" @default.
- W3008532904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32072501" @default.
- W3008532904 hasPublicationYear "2020" @default.
- W3008532904 type Work @default.
- W3008532904 sameAs 3008532904 @default.
- W3008532904 citedByCount "6" @default.
- W3008532904 countsByYear W30085329042020 @default.