FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008568612> ?p ?o ?g. }

• W3008568612 endingPage "119152" @default.
• W3008568612 startingPage "119152" @default.
• W3008568612 abstract "Microparticles (MPs) with pH-responding macropores have recently proved their significance for the delivery of vulnerable biomolecules for oral drug administration. The previous MP systems were proven to provide enhanced protection against the gastric environment, however, their application is hindered due to insufficient loading efficiencies and deficient penetration capabilities of encapsulated drugs across the mucus barrier. Here, we report a new co-delivery approach based on amine-functionalized halloysite nanotube (HNT)-embedded MPs (amine-HNT-MPs) with pH-responding macropores specifically designed to deal with the mucus barrier at the absorption site. The mean diameter and polydispersity index of the pored MPs were measured by a particle size analyzer to be 37.6 ± 1.3 µm and 1.15, respectively. The drug loading capacity of the co-delivery system was shown to be 50-times higher than previously reported pored MPs. Fluorescence microscopy analysis of sulforhodamine B (into a hollow interior of HNTs)/ fluorescent nanoparticles (into a hollow interior of MPs)-encapsulated MPs confirmed biphasic release behavior due to pH-dependent pore closing/opening in the simulated gastrointestinal (GI) digestive conditions. To verify the protective effect of the co-delivery system, bromelain and lactase were loaded into HNTs and MPs, respectively, and found to exhibit 94.5 ± 3.3% (bromelain) and 70 ± 14.1% (lactase) functional activity in simulated GI tract conditions. The considerable improvement in the stability of the encapsulated enzymes against gastric conditions are attributed to the efficient pore sealing of the co-delivery system after the encapsulation of enzymes and maintenance of these closed pores in the gastric environment. Furthermore, the mucolytic enzyme (i.e. bromelain)-encapsulated co-delivery system was found to enhance mucopenetration of the encapsulated drug from histological analysis using ex vivo porcine intestine tissue. Therefore, the new microencapsulation design proposed in this study provides a promising solution to the major issues hampering the wide-spread application of MPs in the development of oral drug formulations for biopharmaceuticals and vaccines." @default.
• W3008568612 created "2020-03-06" @default.
• W3008568612 creator A5000839263 @default.
• W3008568612 creator A5063979057 @default.
• W3008568612 date "2020-04-01" @default.
• W3008568612 modified "2023-09-25" @default.
• W3008568612 title "Halloysite nanotube-embedded microparticles for intestine-targeted co-delivery of biopharmaceuticals" @default.
• W3008568612 cites W1540828078 @default.
• W3008568612 cites W1611749960 @default.
• W3008568612 cites W1929445570 @default.
• W3008568612 cites W1968417558 @default.
• W3008568612 cites W1983653920 @default.
• W3008568612 cites W1985136065 @default.
• W3008568612 cites W1987148128 @default.
• W3008568612 cites W1988016604 @default.
• W3008568612 cites W1992624394 @default.
• W3008568612 cites W1992937533 @default.
• W3008568612 cites W1994294415 @default.
• W3008568612 cites W1996344455 @default.
• W3008568612 cites W2015557020 @default.
• W3008568612 cites W2016090361 @default.
• W3008568612 cites W2019392143 @default.
• W3008568612 cites W2021859397 @default.
• W3008568612 cites W2022905205 @default.
• W3008568612 cites W2024817650 @default.
• W3008568612 cites W2030472918 @default.
• W3008568612 cites W2033663157 @default.
• W3008568612 cites W2055037481 @default.
• W3008568612 cites W2055454300 @default.
• W3008568612 cites W2064567039 @default.
• W3008568612 cites W2077321573 @default.
• W3008568612 cites W2078358739 @default.
• W3008568612 cites W2082219228 @default.
• W3008568612 cites W2082732215 @default.
• W3008568612 cites W2094577650 @default.
• W3008568612 cites W2118854565 @default.
• W3008568612 cites W2125102728 @default.
• W3008568612 cites W2133667721 @default.
• W3008568612 cites W2141037169 @default.
• W3008568612 cites W2144205081 @default.
• W3008568612 cites W2162803526 @default.
• W3008568612 cites W2170008613 @default.
• W3008568612 cites W2256219273 @default.
• W3008568612 cites W2316071747 @default.
• W3008568612 cites W2412659745 @default.
• W3008568612 cites W2418251595 @default.
• W3008568612 cites W2422625570 @default.
• W3008568612 cites W2477103182 @default.
• W3008568612 cites W2584729529 @default.
• W3008568612 cites W2619324674 @default.
• W3008568612 cites W2619669967 @default.
• W3008568612 cites W2751650389 @default.
• W3008568612 cites W2754709330 @default.
• W3008568612 cites W2765539956 @default.
• W3008568612 cites W2765561039 @default.
• W3008568612 cites W2766035640 @default.
• W3008568612 cites W2766697697 @default.
• W3008568612 cites W2767159049 @default.
• W3008568612 cites W2768366016 @default.
• W3008568612 cites W2769152316 @default.
• W3008568612 cites W2799968437 @default.
• W3008568612 cites W2803527252 @default.
• W3008568612 cites W2805066221 @default.
• W3008568612 cites W2807057655 @default.
• W3008568612 cites W2884138041 @default.
• W3008568612 cites W2886781939 @default.
• W3008568612 cites W2889289556 @default.
• W3008568612 cites W2892617128 @default.
• W3008568612 cites W2921550223 @default.
• W3008568612 cites W4255922903 @default.
• W3008568612 doi "https://doi.org/10.1016/j.ijpharm.2020.119152" @default.
• W3008568612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32081802" @default.
• W3008568612 hasPublicationYear "2020" @default.
• W3008568612 type Work @default.
• W3008568612 sameAs 3008568612 @default.
• W3008568612 citedByCount "11" @default.
• W3008568612 countsByYear W30085686122020 @default.
• W3008568612 countsByYear W30085686122021 @default.
• W3008568612 countsByYear W30085686122022 @default.
• W3008568612 crossrefType "journal-article" @default.
• W3008568612 hasAuthorship W3008568612A5000839263 @default.
• W3008568612 hasAuthorship W3008568612A5063979057 @default.
• W3008568612 hasConcept C11432220 @default.
• W3008568612 hasConcept C12554922 @default.
• W3008568612 hasConcept C127413603 @default.
• W3008568612 hasConcept C13245373 @default.
• W3008568612 hasConcept C163588942 @default.
• W3008568612 hasConcept C171250308 @default.
• W3008568612 hasConcept C178790620 @default.
• W3008568612 hasConcept C185592680 @default.
• W3008568612 hasConcept C18903297 @default.
• W3008568612 hasConcept C192562407 @default.
• W3008568612 hasConcept C2777135253 @default.
• W3008568612 hasConcept C2777312293 @default.
• W3008568612 hasConcept C2777521759 @default.
• W3008568612 hasConcept C2779820397 @default.
• W3008568612 hasConcept C42360764 @default.
• W3008568612 hasConcept C43617362 @default.

• next