FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008572413> ?p ?o ?g. }

• W3008572413 endingPage "89" @default.
• W3008572413 startingPage "84" @default.
• W3008572413 abstract "Abstract Aims Insomnia, intelligence and neuroticism are three typical traits and dysfunctions mainly regulated by human brain. Our research aimed to explore the potential genetic relationships between brain function related traits and more than 3000 human plasma proteins. Materials and Methods We conducted a large-scale genetic correlation scan of human plasma proteins and three brain function related traits, including insomnia, intelligence and neuroticism. Linkage disequilibrium score regression (LDSC) analysis was performed to estimate the genetic correlations between each of the blood proteins and insomnia, intelligence and neuroticism via utilizing the genome-wide association study summary statistics of plasma proteins and those three traits. Results LDSC analysis identified 18 specific plasma proteins shown suggestive genetic correlations with insomnia such as Periostin (coefficient=-0.3910, P value = 0.0070). Twenty-one plasma proteins exhibited genetic correlations with intelligence such as Ecto-ADP-ribosyltransferase 3 (coefficient = 0.3066, P value = 0.0013). Six specific plasma proteins shown suggestive genetic correlations with neuroticism, such as CD70 antigen (coefficient = 0.2979, P value = 0.0134). After further comparing the suggestive proteins between insomnia, intelligence and neuroticism, we detected 3 common plasma proteins shared by insomnia and intelligence such as Periostin (coefficient insomnia =-0.3910, P insomnia value = 0.0070; coefficient intelligence =0.2673, P intelligence value = 0.0159) and Neurexin-1 (coefficient insomnia =-0.2913, P insomnia value = 0.0197; coefficient intelligence = 0.2399, P intelligence value = 0.0035). We also detected 2 common plasma proteins shared by intelligence and neuroticism, including CD70 antigen (coefficient intelligence =-0.2092, P intelligence value = 0.0337; coefficient neuroticism = 0.2979, P neuroticism value = 0.0134). Conclusion Our results provide novel clues for unveiling the functional relevance of plasma proteins and brain function related traits." @default.
• W3008572413 created "2020-03-06" @default.
• W3008572413 creator A5008011094 @default.
• W3008572413 creator A5015048746 @default.
• W3008572413 creator A5029811588 @default.
• W3008572413 creator A5033269764 @default.
• W3008572413 creator A5042453764 @default.
• W3008572413 creator A5044757881 @default.
• W3008572413 creator A5052274720 @default.
• W3008572413 creator A5063481044 @default.
• W3008572413 creator A5069645092 @default.
• W3008572413 creator A5073070877 @default.
• W3008572413 creator A5077942573 @default.
• W3008572413 date "2020-05-01" @default.
• W3008572413 modified "2023-10-10" @default.
• W3008572413 title "A large-scale genetic correlation scan identified the plasma proteins associated with brain function related traits" @default.
• W3008572413 cites W1481205317 @default.
• W3008572413 cites W1980430415 @default.
• W3008572413 cites W1987740000 @default.
• W3008572413 cites W1991912110 @default.
• W3008572413 cites W2032634579 @default.
• W3008572413 cites W2056146083 @default.
• W3008572413 cites W2096791516 @default.
• W3008572413 cites W2111307685 @default.
• W3008572413 cites W2130260471 @default.
• W3008572413 cites W2131252214 @default.
• W3008572413 cites W2133797693 @default.
• W3008572413 cites W2153686100 @default.
• W3008572413 cites W2153860431 @default.
• W3008572413 cites W2178041736 @default.
• W3008572413 cites W2195783463 @default.
• W3008572413 cites W2213154417 @default.
• W3008572413 cites W2253188864 @default.
• W3008572413 cites W2293681906 @default.
• W3008572413 cites W2344837706 @default.
• W3008572413 cites W2345621280 @default.
• W3008572413 cites W2511515754 @default.
• W3008572413 cites W2587485320 @default.
• W3008572413 cites W2625502155 @default.
• W3008572413 cites W2684884197 @default.
• W3008572413 cites W2740637836 @default.
• W3008572413 cites W2743818425 @default.
• W3008572413 cites W2745008762 @default.
• W3008572413 cites W2805712258 @default.
• W3008572413 cites W2809193491 @default.
• W3008572413 cites W2809666444 @default.
• W3008572413 cites W2895693082 @default.
• W3008572413 cites W2897469060 @default.
• W3008572413 cites W2898128863 @default.
• W3008572413 cites W2901114620 @default.
• W3008572413 cites W2915402738 @default.
• W3008572413 cites W2942696106 @default.
• W3008572413 cites W2950885009 @default.
• W3008572413 cites W2960281882 @default.
• W3008572413 cites W3003825691 @default.
• W3008572413 cites W4231896431 @default.
• W3008572413 cites W4235444322 @default.
• W3008572413 cites W848361005 @default.
• W3008572413 doi "https://doi.org/10.1016/j.brainresbull.2020.02.017" @default.
• W3008572413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32119964" @default.
• W3008572413 hasPublicationYear "2020" @default.
• W3008572413 type Work @default.
• W3008572413 sameAs 3008572413 @default.
• W3008572413 citedByCount "2" @default.
• W3008572413 countsByYear W30085724132020 @default.
• W3008572413 countsByYear W30085724132022 @default.
• W3008572413 crossrefType "journal-article" @default.
• W3008572413 hasAuthorship W3008572413A5008011094 @default.
• W3008572413 hasAuthorship W3008572413A5015048746 @default.
• W3008572413 hasAuthorship W3008572413A5029811588 @default.
• W3008572413 hasAuthorship W3008572413A5033269764 @default.
• W3008572413 hasAuthorship W3008572413A5042453764 @default.
• W3008572413 hasAuthorship W3008572413A5044757881 @default.
• W3008572413 hasAuthorship W3008572413A5052274720 @default.
• W3008572413 hasAuthorship W3008572413A5063481044 @default.
• W3008572413 hasAuthorship W3008572413A5069645092 @default.
• W3008572413 hasAuthorship W3008572413A5073070877 @default.
• W3008572413 hasAuthorship W3008572413A5077942573 @default.
• W3008572413 hasConcept C104317684 @default.
• W3008572413 hasConcept C117220453 @default.
• W3008572413 hasConcept C14036430 @default.
• W3008572413 hasConcept C169760540 @default.
• W3008572413 hasConcept C205649164 @default.
• W3008572413 hasConcept C2524010 @default.
• W3008572413 hasConcept C2778755073 @default.
• W3008572413 hasConcept C3018390542 @default.
• W3008572413 hasConcept C33923547 @default.
• W3008572413 hasConcept C54355233 @default.
• W3008572413 hasConcept C58640448 @default.
• W3008572413 hasConcept C68873052 @default.
• W3008572413 hasConcept C70616004 @default.
• W3008572413 hasConcept C70721500 @default.
• W3008572413 hasConcept C78458016 @default.
• W3008572413 hasConcept C86803240 @default.
• W3008572413 hasConceptScore W3008572413C104317684 @default.
• W3008572413 hasConceptScore W3008572413C117220453 @default.
• W3008572413 hasConceptScore W3008572413C14036430 @default.
• W3008572413 hasConceptScore W3008572413C169760540 @default.

• next