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• W3008581010 abstract "Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly discovered enteric coronavirus, is the aetiological agent that causes severe clinical diarrhea and intestinal pathological damage in piglets. To understand the effect of SADS-CoV on host cells, we characterized the apoptotic pathways and elucidated mechanisms underlying the process of apoptotic cell death after SADS-CoV infection. SADS-CoV-infected cells showed evidence of apoptosis in vitro and in vivo. The use of a pan-caspase inhibitor resulted in the inhibition of SADS-CoV-induced apoptosis and reduction in SADS-CoV replication, suggestive of the association of a caspase-dependent pathway. Furthermore, SADS-CoV infection activated the initiators caspase-8 and -9 and upregulated FasL and Bid cleavage, demonstrating a crosstalk between the extrinsic and intrinsic pathways. However, the proapoptotic proteins Bax and Cytochrome c (Cyt c) relocalized to the mitochondria and cytoplasm, respectively, after infection by SADS-CoV. Moreover, Vero E6 and IPI-2I cells treated with cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition pore (MPTP) opening, were completely protected from SADS-CoV-induced apoptosis and viral replication, suggesting the involvement of cyclophilin D (CypD) in these processes. Altogether, our results indicate that caspase-dependent FasL (extrinsic)- and mitochondria (intrinsic)- mediated apoptotic pathways play a central role in SADS-CoV-induced apoptosis that facilitates viral replication. In summary, these findings demonstrate mechanisms by which SADS-CoV induces apoptosis and improve our understanding of SADS-CoV pathogenesis." @default.
• W3008581010 created "2020-03-06" @default.
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• W3008581010 date "2020-01-01" @default.
• W3008581010 modified "2023-09-23" @default.
• W3008581010 title "Swine acute diarrhea syndrome coronavirus-induced apoptosis is caspase- and cyclophilin D- dependent" @default.
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• W3008581010 doi "https://doi.org/10.1080/22221751.2020.1722758" @default.
• W3008581010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7054944" @default.
• W3008581010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32090691" @default.
• W3008581010 hasPublicationYear "2020" @default.
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