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- W3008593865 abstract "Abstract Study was continued on the animal hemoglobin repletion test for measuring bioavailability of iron. With most iron sources, similar results were obtained with chicks and with rats. An important exception was noted with reduced iron. Seventeen samples were tested for solubility in dilute HCl and for bioavailability when fed to chicks and rats. The chicks utilized all samples reasonably well, but the rats were not able to efficiently utilize samples with particle sizes greater than 325 mesh. The mean relative biological value (vs. FeSO4 = 100) for the 17 samples was 50.5 ±8.3 when tested with chicks and 32.3±17.7 when tested with rats. Some, but not all, of the differences could be explained on the basis of particle size distribution. Similar relative biological values were obtained when the sample of reduced iron was added directly to the test diet or when it was used to enrich flour which was subsequently baked into bread and the bread was then added to the test diet. Plasma iron responses in human volunteers following test doses of the reduced iron samples were more closely related to the rat data, and this suggested that rats were the preferred species to measure bioavailability for man. The rat data also measured bioavailability of iron for guinea pigs." @default.
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- W3008593865 date "1973-11-01" @default.
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- W3008593865 title "Comparison of Chicks and Rats as Test Animals for Studying Bioavailability of Iron, with Special Reference to Use of Reduced Iron in Enriched Bread" @default.
- W3008593865 doi "https://doi.org/10.1093/jaoac/56.6.1369" @default.
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