FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008630502> ?p ?o ?g. }

• W3008630502 endingPage "203" @default.
• W3008630502 startingPage "197" @default.
• W3008630502 abstract "Glaucoma is a leading cause of blindness worldwide with complex pathogenesis. The excessive proliferation and fibrosis of human tenon capsule fibroblasts (HTFs) trigger the scar formation after glaucoma filtration surgery. The purpose was to investigate the role of long intergenic non-protein coding RNA 28 (LINC00028) and mechanism in transforming growth factor β1 (TGFβ1)-treated HTFs. The detection of LINC00028 and miR-204-5p expression was conducted using quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation was assessed by cell counting kit-8 (CCK-8) assay. Cell migration and invasion were monitored by transwell assay. The expression of Epithelial-mesenchymal transition (EMT)-related markers, including E-cadherin, α-Smooth muscle actin (α-SMA), fibronectin and β-catenin, and autophagy-related markers, including Beclin 1 and light chain 3 (LC3-II and LC3-I) at the protein level was quantified using western blot. The prediction of the relationship between LINC00028 and miR-204-5p was performed by the online tool miRcode, and the verification of the relationship between them was conducted using dual-luciferase reporter assay, RNA immunoprecipitation (RIP) assay and RNA pull-down assay. The expression of LINC00028 was elevated in glaucoma tissues and TGFβ1-treated HTFs. LINC00028 downregulation blocked proliferation, migration, invasion, EMT, fibrosis and autophagy of TGFβ1-treated HTFs. MiR-204-5p was a target of LINC00028, and its reintroduction exerted a similar role of LINC00028 downregulation. The inhibition of miR-204-5p reversed the effects of LINC00028 downregulation in TGFβ1-treated HTFs. LINC00028 regulated proliferation, migration, invasion, EMT, fibrosis and autophagy to induce the development of HTFs by competitively targeting miR-204-5p, and LINC00028 was regarded as a promising biomarker for glaucoma filtration treatment." @default.
• W3008630502 created "2020-03-06" @default.
• W3008630502 creator A5016622484 @default.
• W3008630502 creator A5030031217 @default.
• W3008630502 creator A5047385796 @default.
• W3008630502 creator A5060470732 @default.
• W3008630502 creator A5064083258 @default.
• W3008630502 creator A5084589920 @default.
• W3008630502 creator A5089515196 @default.
• W3008630502 date "2020-04-01" @default.
• W3008630502 modified "2023-09-23" @default.
• W3008630502 title "LINC00028 regulates the development of TGFβ1-treated human tenon capsule fibroblasts by targeting miR-204-5p" @default.
• W3008630502 cites W106929470 @default.
• W3008630502 cites W1596603769 @default.
• W3008630502 cites W2003521072 @default.
• W3008630502 cites W2016193552 @default.
• W3008630502 cites W2034742711 @default.
• W3008630502 cites W2045518060 @default.
• W3008630502 cites W2050834222 @default.
• W3008630502 cites W2078655226 @default.
• W3008630502 cites W2499240546 @default.
• W3008630502 cites W2569023336 @default.
• W3008630502 cites W2626809623 @default.
• W3008630502 cites W2765559595 @default.
• W3008630502 cites W2772802019 @default.
• W3008630502 cites W2792240513 @default.
• W3008630502 cites W2911008581 @default.
• W3008630502 cites W2965604754 @default.
• W3008630502 cites W2972688406 @default.
• W3008630502 cites W2973602287 @default.
• W3008630502 cites W2976348050 @default.
• W3008630502 cites W2983201428 @default.
• W3008630502 cites W992567281 @default.
• W3008630502 doi "https://doi.org/10.1016/j.bbrc.2020.01.096" @default.
• W3008630502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32085895" @default.
• W3008630502 hasPublicationYear "2020" @default.
• W3008630502 type Work @default.
• W3008630502 sameAs 3008630502 @default.
• W3008630502 citedByCount "13" @default.
• W3008630502 countsByYear W30086305022020 @default.
• W3008630502 countsByYear W30086305022021 @default.
• W3008630502 countsByYear W30086305022022 @default.
• W3008630502 countsByYear W30086305022023 @default.
• W3008630502 crossrefType "journal-article" @default.
• W3008630502 hasAuthorship W3008630502A5016622484 @default.
• W3008630502 hasAuthorship W3008630502A5030031217 @default.
• W3008630502 hasAuthorship W3008630502A5047385796 @default.
• W3008630502 hasAuthorship W3008630502A5060470732 @default.
• W3008630502 hasAuthorship W3008630502A5064083258 @default.
• W3008630502 hasAuthorship W3008630502A5084589920 @default.
• W3008630502 hasAuthorship W3008630502A5089515196 @default.
• W3008630502 hasConcept C104317684 @default.
• W3008630502 hasConcept C118131993 @default.
• W3008630502 hasConcept C127561419 @default.
• W3008630502 hasConcept C137738243 @default.
• W3008630502 hasConcept C142724271 @default.
• W3008630502 hasConcept C1491633281 @default.
• W3008630502 hasConcept C153911025 @default.
• W3008630502 hasConcept C185592680 @default.
• W3008630502 hasConcept C189165786 @default.
• W3008630502 hasConcept C2776415932 @default.
• W3008630502 hasConcept C2780559512 @default.
• W3008630502 hasConcept C502942594 @default.
• W3008630502 hasConcept C55493867 @default.
• W3008630502 hasConcept C62112901 @default.
• W3008630502 hasConcept C71924100 @default.
• W3008630502 hasConcept C76419328 @default.
• W3008630502 hasConcept C86492073 @default.
• W3008630502 hasConcept C86803240 @default.
• W3008630502 hasConcept C95444343 @default.
• W3008630502 hasConceptScore W3008630502C104317684 @default.
• W3008630502 hasConceptScore W3008630502C118131993 @default.
• W3008630502 hasConceptScore W3008630502C127561419 @default.
• W3008630502 hasConceptScore W3008630502C137738243 @default.
• W3008630502 hasConceptScore W3008630502C142724271 @default.
• W3008630502 hasConceptScore W3008630502C1491633281 @default.
• W3008630502 hasConceptScore W3008630502C153911025 @default.
• W3008630502 hasConceptScore W3008630502C185592680 @default.
• W3008630502 hasConceptScore W3008630502C189165786 @default.
• W3008630502 hasConceptScore W3008630502C2776415932 @default.
• W3008630502 hasConceptScore W3008630502C2780559512 @default.
• W3008630502 hasConceptScore W3008630502C502942594 @default.
• W3008630502 hasConceptScore W3008630502C55493867 @default.
• W3008630502 hasConceptScore W3008630502C62112901 @default.
• W3008630502 hasConceptScore W3008630502C71924100 @default.
• W3008630502 hasConceptScore W3008630502C76419328 @default.
• W3008630502 hasConceptScore W3008630502C86492073 @default.
• W3008630502 hasConceptScore W3008630502C86803240 @default.
• W3008630502 hasConceptScore W3008630502C95444343 @default.
• W3008630502 hasFunder F4320324174 @default.
• W3008630502 hasIssue "1" @default.
• W3008630502 hasLocation W30086305021 @default.
• W3008630502 hasLocation W30086305022 @default.
• W3008630502 hasOpenAccess W3008630502 @default.
• W3008630502 hasPrimaryLocation W30086305021 @default.
• W3008630502 hasRelatedWork W1967767010 @default.
• W3008630502 hasRelatedWork W2008978535 @default.
• W3008630502 hasRelatedWork W2366023036 @default.

• next