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- W3008637341 endingPage "1900108" @default.
- W3008637341 startingPage "1900108" @default.
- W3008637341 abstract "Studies performed in absence of gravitational constraint show that a living system is unable to choose between two different phenotypes, thus leading cells to segregate into different, alternative stable states. This finding demonstrates that the genotype does not determine by itself the phenotype but requires additional, physical constraints to finalize cell differentiation. Constraints belong to two classes: holonomic (independent of the system's dynamical states, as being established by the space-time geometry of the field) and non-holonomic (modified during those biological processes to which they contribute in shaping). This latter kind of constraints, in which dynamics works on the constraint to recreate them, have emerged as critical determinants of self-organizing systems, by manifesting a closure of constraints. Overall, the constraints act by harnessing the randomness represented by the simultaneous presence of equiprobable events restraining the system within one attractor. These results cast doubt on the mainstream scientific concept and call for a better understanding of causation in cell biology." @default.
- W3008637341 created "2020-03-06" @default.
- W3008637341 creator A5011114447 @default.
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- W3008637341 creator A5026004491 @default.
- W3008637341 creator A5043740687 @default.
- W3008637341 creator A5059087170 @default.
- W3008637341 date "2020-04-01" @default.
- W3008637341 modified "2023-09-26" @default.
- W3008637341 title "Constraints Shape Cell Function and Morphology by Canalizing the Developmental Path along the Waddington's Landscape" @default.
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