FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008638208> ?p ?o ?g. }

• W3008638208 endingPage "1496" @default.
• W3008638208 startingPage "1481" @default.
• W3008638208 abstract "With increasing incidence, pancreatic cancer (PC) is one of the most common digestive tract tumors. However, the prognosis of PC is particularly dismal due to the highly invasive and metastatic behavior of this deadly disease. DEP domain-containing protein 1B (DEPDC1B), which is overexpressed in multiple tumors, such as breast cancer, oral cancer and non-small cell lung cancer, plays a significant role in cell movement, cell cycle and cytoskeleton reorganization. However, the function of DEPDC1B in PC remains poorly understood.The function of DEPDC1B in the migration and invasion of PC was evaluated by wound healing and Transwell assays in vitro and PC-derived liver metastasis models in vivo. The molecular mechanisms of DEPDC1B were investigated through cell line establishment, Western blotting, qRT-PCR, immunoprecipitation, histological examination and immunohistochemistry analysis.DEPDC1B was overexpressed in PC cell lines. DEPDC1B regulated cell migration and invasion. DEPDC1B regulated the Rac1/PAK1-LIMK1-cofilin1 signaling pathway by interacting with Rac1. Rac1 inhibition suppressed DEPDC1B-induced migration and invasion in PC in vitro and DEPDC1B-induced liver metastasis in vivo.DEPDC1B promoted cell migration and invasion by activating the Rac1/PAK1-LIMK1-cofilin1 signaling pathway, thus providing a potential therapeutic target against PC." @default.
• W3008638208 created "2020-03-06" @default.
• W3008638208 creator A5004853365 @default.
• W3008638208 creator A5008387548 @default.
• W3008638208 creator A5017030904 @default.
• W3008638208 creator A5021925733 @default.
• W3008638208 creator A5024039493 @default.
• W3008638208 creator A5025327806 @default.
• W3008638208 creator A5029878935 @default.
• W3008638208 creator A5034083482 @default.
• W3008638208 creator A5037247754 @default.
• W3008638208 creator A5060522744 @default.
• W3008638208 creator A5070581436 @default.
• W3008638208 date "2020-02-01" @default.
• W3008638208 modified "2023-10-16" @default.
• W3008638208 title "<p>DEP Domain-Containing Protein 1B (DEPDC1B) Promotes Migration and Invasion in Pancreatic Cancer Through the Rac1/PAK1-LIMK1-Cofilin1 Signaling Pathway</p>" @default.
• W3008638208 cites W1546162979 @default.
• W3008638208 cites W1584251725 @default.
• W3008638208 cites W1997008264 @default.
• W3008638208 cites W2005591572 @default.
• W3008638208 cites W2006996655 @default.
• W3008638208 cites W2044605643 @default.
• W3008638208 cites W2066767494 @default.
• W3008638208 cites W2083904574 @default.
• W3008638208 cites W2088053383 @default.
• W3008638208 cites W2094727098 @default.
• W3008638208 cites W2111479290 @default.
• W3008638208 cites W2116408250 @default.
• W3008638208 cites W2120111809 @default.
• W3008638208 cites W2136358702 @default.
• W3008638208 cites W2138155367 @default.
• W3008638208 cites W2149063573 @default.
• W3008638208 cites W2152616334 @default.
• W3008638208 cites W2291130583 @default.
• W3008638208 cites W2301751918 @default.
• W3008638208 cites W2328860188 @default.
• W3008638208 cites W2592447625 @default.
• W3008638208 cites W2731867176 @default.
• W3008638208 cites W2731978218 @default.
• W3008638208 cites W2760630616 @default.
• W3008638208 cites W2775062021 @default.
• W3008638208 cites W2803441813 @default.
• W3008638208 cites W2810321039 @default.
• W3008638208 cites W2893843888 @default.
• W3008638208 cites W2921887115 @default.
• W3008638208 cites W2950773580 @default.
• W3008638208 cites W2957304183 @default.
• W3008638208 cites W2960459437 @default.
• W3008638208 cites W4211208840 @default.
• W3008638208 cites W4240103271 @default.
• W3008638208 cites W4244578979 @default.
• W3008638208 doi "https://doi.org/10.2147/ott.s229055" @default.
• W3008638208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7035893" @default.
• W3008638208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32110046" @default.
• W3008638208 hasPublicationYear "2020" @default.
• W3008638208 type Work @default.
• W3008638208 sameAs 3008638208 @default.
• W3008638208 citedByCount "22" @default.
• W3008638208 countsByYear W30086382082020 @default.
• W3008638208 countsByYear W30086382082021 @default.
• W3008638208 countsByYear W30086382082022 @default.
• W3008638208 countsByYear W30086382082023 @default.
• W3008638208 crossrefType "journal-article" @default.
• W3008638208 hasAuthorship W3008638208A5004853365 @default.
• W3008638208 hasAuthorship W3008638208A5008387548 @default.
• W3008638208 hasAuthorship W3008638208A5017030904 @default.
• W3008638208 hasAuthorship W3008638208A5021925733 @default.
• W3008638208 hasAuthorship W3008638208A5024039493 @default.
• W3008638208 hasAuthorship W3008638208A5025327806 @default.
• W3008638208 hasAuthorship W3008638208A5029878935 @default.
• W3008638208 hasAuthorship W3008638208A5034083482 @default.
• W3008638208 hasAuthorship W3008638208A5037247754 @default.
• W3008638208 hasAuthorship W3008638208A5060522744 @default.
• W3008638208 hasAuthorship W3008638208A5070581436 @default.
• W3008638208 hasBestOaLocation W30086382081 @default.
• W3008638208 hasConcept C104317684 @default.
• W3008638208 hasConcept C121608353 @default.
• W3008638208 hasConcept C126322002 @default.
• W3008638208 hasConcept C137738243 @default.
• W3008638208 hasConcept C142724271 @default.
• W3008638208 hasConcept C1491633281 @default.
• W3008638208 hasConcept C2779013556 @default.
• W3008638208 hasConcept C2779717556 @default.
• W3008638208 hasConcept C2780210213 @default.
• W3008638208 hasConcept C29537977 @default.
• W3008638208 hasConcept C502942594 @default.
• W3008638208 hasConcept C54355233 @default.
• W3008638208 hasConcept C55493867 @default.
• W3008638208 hasConcept C62478195 @default.
• W3008638208 hasConcept C71924100 @default.
• W3008638208 hasConcept C85265743 @default.
• W3008638208 hasConcept C86803240 @default.
• W3008638208 hasConcept C95444343 @default.
• W3008638208 hasConceptScore W3008638208C104317684 @default.
• W3008638208 hasConceptScore W3008638208C121608353 @default.
• W3008638208 hasConceptScore W3008638208C126322002 @default.
• W3008638208 hasConceptScore W3008638208C137738243 @default.
• W3008638208 hasConceptScore W3008638208C142724271 @default.

• next