Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008654110> ?p ?o ?g. }
- W3008654110 endingPage "105275" @default.
- W3008654110 startingPage "105275" @default.
- W3008654110 abstract "The antitumor activity of doxorubicin (DOX) is often limited owing to the occurrence of multidrug resistance (MDR) during treatment. Herein, we developed hybrid polymeric micelles, which consisted of pluronic F127 as long-circulating helper in blood, and phenylboronic ester-grafted pluronic P123 (PHE) as efflux and detoxification regulator to efficiently deliver DOX and reverse MDR in vivo. Hybrid F127/PHE micelles exhibited higher stability and drug encapsulation (~80%) than simple F127/P123 micelles due to its lower CMC, and displayed in vitro drug release in a hydrogen peroxide (H2O2)-sensitive manner. Besides, DOX-loaded hybrid micelles (F127/PHE-DOX) possessed higher cell-killing ability and induce more apoptotic in MDR-cells than other groups, which was probably because it not only could greatly increase intracellular drug concentration by inhibiting P-gp mediated drug efflux, but also promote reactive oxygen species (ROS) generation by decreasing glutathione (GSH) levels. Besides, in vivo evaluation indicated that F127/PHE-DOX could well accumulate at tumor regions and exhibit the strongest tumor growth inhibition (TGI 87.87%) accompanied with low side effects. As a result, F127/PHE micelles had great potentials as a platform for anticancer drugs delivery and tumor MDR reversal in clinical application." @default.
- W3008654110 created "2020-03-06" @default.
- W3008654110 creator A5000665985 @default.
- W3008654110 creator A5006822602 @default.
- W3008654110 creator A5016902320 @default.
- W3008654110 creator A5020082198 @default.
- W3008654110 creator A5038314144 @default.
- W3008654110 date "2020-04-01" @default.
- W3008654110 modified "2023-10-17" @default.
- W3008654110 title "Pluronic micelles with suppressing doxorubicin efflux and detoxification for efficiently reversing breast cancer resistance" @default.
- W3008654110 cites W1724734751 @default.
- W3008654110 cites W1963618034 @default.
- W3008654110 cites W1965443653 @default.
- W3008654110 cites W1976915466 @default.
- W3008654110 cites W1978210381 @default.
- W3008654110 cites W1982056054 @default.
- W3008654110 cites W1987104113 @default.
- W3008654110 cites W1991609273 @default.
- W3008654110 cites W1992473950 @default.
- W3008654110 cites W1996993122 @default.
- W3008654110 cites W2007714886 @default.
- W3008654110 cites W2008006215 @default.
- W3008654110 cites W2010183849 @default.
- W3008654110 cites W2015346163 @default.
- W3008654110 cites W2017936372 @default.
- W3008654110 cites W2029351008 @default.
- W3008654110 cites W2033770623 @default.
- W3008654110 cites W2035045849 @default.
- W3008654110 cites W2063891273 @default.
- W3008654110 cites W2069360982 @default.
- W3008654110 cites W2074525949 @default.
- W3008654110 cites W2083887808 @default.
- W3008654110 cites W2096258216 @default.
- W3008654110 cites W2106926141 @default.
- W3008654110 cites W2163758521 @default.
- W3008654110 cites W2165535625 @default.
- W3008654110 cites W2171384411 @default.
- W3008654110 cites W2252303073 @default.
- W3008654110 cites W2287116827 @default.
- W3008654110 cites W2332035638 @default.
- W3008654110 cites W2442084011 @default.
- W3008654110 cites W2465398523 @default.
- W3008654110 cites W2474886141 @default.
- W3008654110 cites W2490849378 @default.
- W3008654110 cites W2530774954 @default.
- W3008654110 cites W2554773181 @default.
- W3008654110 cites W2560148160 @default.
- W3008654110 cites W2581743176 @default.
- W3008654110 cites W2585870725 @default.
- W3008654110 cites W2588056735 @default.
- W3008654110 cites W2590680367 @default.
- W3008654110 cites W2592268248 @default.
- W3008654110 cites W2736086618 @default.
- W3008654110 cites W2789440868 @default.
- W3008654110 cites W2790913916 @default.
- W3008654110 cites W2791641962 @default.
- W3008654110 cites W2792944760 @default.
- W3008654110 cites W2800771680 @default.
- W3008654110 cites W2803857613 @default.
- W3008654110 cites W2809277431 @default.
- W3008654110 cites W2887238932 @default.
- W3008654110 cites W2888982034 @default.
- W3008654110 cites W2889711816 @default.
- W3008654110 cites W2897615486 @default.
- W3008654110 cites W2899160073 @default.
- W3008654110 cites W2902264537 @default.
- W3008654110 cites W2904562410 @default.
- W3008654110 cites W2982482631 @default.
- W3008654110 doi "https://doi.org/10.1016/j.ejps.2020.105275" @default.
- W3008654110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32087259" @default.
- W3008654110 hasPublicationYear "2020" @default.
- W3008654110 type Work @default.
- W3008654110 sameAs 3008654110 @default.
- W3008654110 citedByCount "30" @default.
- W3008654110 countsByYear W30086541102020 @default.
- W3008654110 countsByYear W30086541102021 @default.
- W3008654110 countsByYear W30086541102022 @default.
- W3008654110 countsByYear W30086541102023 @default.
- W3008654110 crossrefType "journal-article" @default.
- W3008654110 hasAuthorship W3008654110A5000665985 @default.
- W3008654110 hasAuthorship W3008654110A5006822602 @default.
- W3008654110 hasAuthorship W3008654110A5016902320 @default.
- W3008654110 hasAuthorship W3008654110A5020082198 @default.
- W3008654110 hasAuthorship W3008654110A5038314144 @default.
- W3008654110 hasConcept C101335993 @default.
- W3008654110 hasConcept C11268172 @default.
- W3008654110 hasConcept C121608353 @default.
- W3008654110 hasConcept C126322002 @default.
- W3008654110 hasConcept C142724271 @default.
- W3008654110 hasConcept C147789679 @default.
- W3008654110 hasConcept C15920480 @default.
- W3008654110 hasConcept C159985019 @default.
- W3008654110 hasConcept C178790620 @default.
- W3008654110 hasConcept C184651966 @default.
- W3008654110 hasConcept C185592680 @default.
- W3008654110 hasConcept C192562407 @default.
- W3008654110 hasConcept C200082930 @default.
- W3008654110 hasConcept C204787440 @default.