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- W3008708678 abstract "Abstract Medical intervention in young people at risk for the development of psychosis includes treatment with antipsychotic medication and other pharmaceutical approaches. Several second-generation antipsychotics (amisulpride, aripiprazole, olanzapine, perospirone, risperidone) and agents such as antidepressants, lithium, polyunsaturated fatty acids (PUFAs), and NMDA receptor coagonists have been tested in clinical trials in high-risk populations. The study results imply a comparable positive effect of antipsychotic medication and psychotherapy on symptom severity. An additional effect of pharmacotherapy when added to psychosocial interventions was not proven. Promising results about preventive effects of PUFAs have not been replicated. d -Serine reduced negative symptoms in a randomized controlled trial (RCT), but further research with larger sample sizes is needed. Other agents have not been tested in RCTs yet. Based on the current state of research and international clinical guidelines, the use of antipsychotic drugs and other pharmacological agents cannot be recommended in the treatment of subthreshold psychotic symptoms or with the aim to prevent the onset of psychosis." @default.
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- W3008708678 date "2020-01-01" @default.
- W3008708678 modified "2023-10-16" @default.
- W3008708678 title "Pharmacological intervention for people at risk of psychotic disorder" @default.
- W3008708678 doi "https://doi.org/10.1016/b978-0-12-813201-2.00019-3" @default.
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