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• W3008708992 abstract "Abstract Endonuclease V (EndoV) is a conserved inosine-specific ribonuclease with unknown biological function. Here, we present the first mouse model lacking EndoV, which is viable without visible abnormalities. We show that endogenous murine EndoV cleaves inosine-containing RNA in vitro, nevertheless a series of experiments fails to link an in vivo function to processing of such transcripts. As inosine levels and adenosine-to-inosine editing often are dysregulated in hepatocellular carcinoma (HCC), we chemically induced HCC in mice. All mice developed liver cancer, however, EndoV−/− tumors were significantly fewer and smaller than wild type tumors. Opposed to human HCC, adenosine deaminase mRNA expression and site-specific editing were unaltered in our model. Loss of EndoV did not affect editing levels in liver tumors, however mRNA expression of a selection of cancer related genes were reduced. Inosines are also found in certain tRNAs and tRNAs are cleaved during stress to produce signaling entities. tRNA fragmentation was dysregulated in EndoV−/− livers and apparently, inosine-independent. We speculate that the inosine-ribonuclease activity of EndoV is disabled in vivo, but RNA binding allowed to promote stabilization of transcripts or recruitment of proteins to fine-tune gene expression. The EndoV−/− tumor suppressive phenotype calls for related studies in human HCC." @default.
• W3008708992 created "2020-03-06" @default.
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• W3008708992 date "2020-02-21" @default.
• W3008708992 modified "2023-10-15" @default.
• W3008708992 title "Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma" @default.
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• W3008708992 cites W1547213195 @default.
• W3008708992 cites W1810708914 @default.
• W3008708992 cites W1832399013 @default.
• W3008708992 cites W1963694561 @default.
• W3008708992 cites W1968157568 @default.
• W3008708992 cites W1971837077 @default.
• W3008708992 cites W1982079498 @default.
• W3008708992 cites W1986272738 @default.
• W3008708992 cites W1987530472 @default.
• W3008708992 cites W1990953759 @default.
• W3008708992 cites W1998364925 @default.
• W3008708992 cites W1998607186 @default.
• W3008708992 cites W1999361121 @default.
• W3008708992 cites W2004590033 @default.
• W3008708992 cites W2006462446 @default.
• W3008708992 cites W2008255393 @default.
• W3008708992 cites W2012800815 @default.
• W3008708992 cites W2013151542 @default.
• W3008708992 cites W2016688357 @default.
• W3008708992 cites W2016828736 @default.
• W3008708992 cites W2022192230 @default.
• W3008708992 cites W2026993656 @default.
• W3008708992 cites W2040681799 @default.
• W3008708992 cites W2041676007 @default.
• W3008708992 cites W2046641567 @default.
• W3008708992 cites W2050646418 @default.
• W3008708992 cites W2052599266 @default.
• W3008708992 cites W2055708350 @default.
• W3008708992 cites W2056376806 @default.
• W3008708992 cites W2060539562 @default.
• W3008708992 cites W2062671971 @default.
• W3008708992 cites W2069646948 @default.
• W3008708992 cites W2071112983 @default.
• W3008708992 cites W2086601589 @default.
• W3008708992 cites W2088017477 @default.
• W3008708992 cites W2089774164 @default.
• W3008708992 cites W2098138732 @default.
• W3008708992 cites W2105241705 @default.
• W3008708992 cites W2106039274 @default.
• W3008708992 cites W2107920354 @default.
• W3008708992 cites W2109140791 @default.
• W3008708992 cites W2120276739 @default.
• W3008708992 cites W2122289183 @default.
• W3008708992 cites W2123497973 @default.
• W3008708992 cites W2130920386 @default.
• W3008708992 cites W2138825103 @default.
• W3008708992 cites W2140729960 @default.
• W3008708992 cites W2141169899 @default.
• W3008708992 cites W2144134250 @default.
• W3008708992 cites W2148542126 @default.
• W3008708992 cites W2155139766 @default.
• W3008708992 cites W2166392925 @default.
• W3008708992 cites W2166676855 @default.
• W3008708992 cites W2167638234 @default.
• W3008708992 cites W2171597027 @default.
• W3008708992 cites W2193739999 @default.
• W3008708992 cites W2334094614 @default.
• W3008708992 cites W2343074972 @default.
• W3008708992 cites W2400869935 @default.
• W3008708992 cites W2418276263 @default.
• W3008708992 cites W2515029422 @default.
• W3008708992 cites W2586411855 @default.
• W3008708992 cites W2608110242 @default.
• W3008708992 cites W2608912729 @default.
• W3008708992 cites W2743919181 @default.
• W3008708992 cites W2745342955 @default.
• W3008708992 cites W2765605277 @default.
• W3008708992 cites W2765822402 @default.
• W3008708992 cites W2768485889 @default.
• W3008708992 cites W2769036773 @default.
• W3008708992 cites W2769188931 @default.
• W3008708992 cites W2804067982 @default.
• W3008708992 cites W2863353632 @default.
• W3008708992 cites W2952763481 @default.
• W3008708992 cites W2953132931 @default.

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