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• W3008747670 endingPage "194508" @default.
• W3008747670 startingPage "194508" @default.
• W3008747670 abstract "The ELL (ELL1 and ELL2)-containing Super Elongation Complex (SEC) is required for efficient HIV-1 transactivation by the viral-encoded Tat protein. EAF1 and EAF2 are ELL-associated factors and considered as positive regulators of ELL. However, their role in HIV-1 transcriptional control is unknown. In this study, we show that EAF1/2 inhibit the SEC-dependent and Tat-activated HIV-1 transcription. EAF1/2 are found to interact with the SEC components in an ELL1/2-dependent manner. Surprisingly, the depletion of EAF1/2 increases the SEC formation and occupancy on the HIV-1 proviral DNA, thereby stimulating Tat transactivation of HIV-1. Although EAF1/2 interact with members of the SEC in a ELL-dependent manner, this interaction competes with the binding of the scaffolding subunit AFF1 with ELL, thus reducing the SEC formation. Together, these data reveal how EAF1/2 regulate the SEC formation to control HIV-1 transcription." @default.
• W3008747670 created "2020-03-06" @default.
• W3008747670 creator A5032020402 @default.
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• W3008747670 date "2020-05-01" @default.
• W3008747670 modified "2023-09-26" @default.
• W3008747670 title "ELL-associated factors EAF1/2 negatively regulate HIV-1 transcription through inhibition of Super Elongation Complex formation" @default.
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• W3008747670 doi "https://doi.org/10.1016/j.bbagrm.2020.194508" @default.
• W3008747670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32087315" @default.
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