Matches in SemOpenAlex for { <https://semopenalex.org/work/W3008772525> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3008772525 abstract "Depression is known to be a risk factor for suicide. Currently, the most used antidepressants are selective serotonin reuptake inhibitors (SSRIs). Not all users, however, benefit from them. In such cases, treatment failure can be explained in part by genetic differences. In this study, we investigated the role of pharmacogenetic factors in citalopram-positive completed suicides (n = 349). Since citalopram is metabolized by CYP2C19 and CYP2D6 enzymes, the study population was genotyped for clinically relevant CYP2C19 and CYP2D6 polymorphisms and CYP2D6 copy number variation. To assess genetic differences between suicide cases and Finns in general, Finnish population samples (n = 855) were used as controls. Also, the role of drug interactions among suicide cases was evaluated. We found enrichment of a combined group of genetically predicted poor and ultrarapid metabolizer phenotypes (gMPs) of CYP2C19 among suicide victims compared to controls 0.356 [0.31–0.41] vs. 0.265 [0.24–0.30] (p = 0.0065). In CYP2D6 gMPs, there was no difference between cases and controls when the study population was analyzed as a whole. However, there were significantly more poor metabolizers among females who committed suicide by poisoning compared to female controls. In 8% of all drug poisoning deaths, lifetime drug-drug interaction was evaluated having a contribution to the fatal outcome. From clinical perspective, pharmacogenetic testing prior to initiation of SSRI drug could be beneficial. It may also be useful in medico-legal settings as it may elucidate obscure poisoning cases. Also, the possibility of unintentional drug interactions should be taken into account in drug poisoning deaths." @default.
- W3008772525 created "2020-03-06" @default.
- W3008772525 creator A5019805039 @default.
- W3008772525 creator A5041475773 @default.
- W3008772525 creator A5047525081 @default.
- W3008772525 creator A5047851431 @default.
- W3008772525 creator A5051334131 @default.
- W3008772525 creator A5054293690 @default.
- W3008772525 creator A5069864713 @default.
- W3008772525 creator A5087533435 @default.
- W3008772525 date "2019-01-01" @default.
- W3008772525 modified "2023-09-24" @default.
- W3008772525 title "Completed suicides of citalopram users-the role of CYP genotypes and adverse drug interactions" @default.
- W3008772525 hasPublicationYear "2019" @default.
- W3008772525 type Work @default.
- W3008772525 sameAs 3008772525 @default.
- W3008772525 citedByCount "0" @default.
- W3008772525 crossrefType "journal-article" @default.
- W3008772525 hasAuthorship W3008772525A5019805039 @default.
- W3008772525 hasAuthorship W3008772525A5041475773 @default.
- W3008772525 hasAuthorship W3008772525A5047525081 @default.
- W3008772525 hasAuthorship W3008772525A5047851431 @default.
- W3008772525 hasAuthorship W3008772525A5051334131 @default.
- W3008772525 hasAuthorship W3008772525A5054293690 @default.
- W3008772525 hasAuthorship W3008772525A5069864713 @default.
- W3008772525 hasAuthorship W3008772525A5087533435 @default.
- W3008772525 hasConcept C104317684 @default.
- W3008772525 hasConcept C118552586 @default.
- W3008772525 hasConcept C126322002 @default.
- W3008772525 hasConcept C135763542 @default.
- W3008772525 hasConcept C140840227 @default.
- W3008772525 hasConcept C170734499 @default.
- W3008772525 hasConcept C2777490545 @default.
- W3008772525 hasConcept C2779177272 @default.
- W3008772525 hasConcept C2780035454 @default.
- W3008772525 hasConcept C2908647359 @default.
- W3008772525 hasConcept C33664856 @default.
- W3008772525 hasConcept C526171541 @default.
- W3008772525 hasConcept C54355233 @default.
- W3008772525 hasConcept C55775858 @default.
- W3008772525 hasConcept C558461103 @default.
- W3008772525 hasConcept C62231903 @default.
- W3008772525 hasConcept C71924100 @default.
- W3008772525 hasConcept C86803240 @default.
- W3008772525 hasConcept C98274493 @default.
- W3008772525 hasConcept C99454951 @default.
- W3008772525 hasConceptScore W3008772525C104317684 @default.
- W3008772525 hasConceptScore W3008772525C118552586 @default.
- W3008772525 hasConceptScore W3008772525C126322002 @default.
- W3008772525 hasConceptScore W3008772525C135763542 @default.
- W3008772525 hasConceptScore W3008772525C140840227 @default.
- W3008772525 hasConceptScore W3008772525C170734499 @default.
- W3008772525 hasConceptScore W3008772525C2777490545 @default.
- W3008772525 hasConceptScore W3008772525C2779177272 @default.
- W3008772525 hasConceptScore W3008772525C2780035454 @default.
- W3008772525 hasConceptScore W3008772525C2908647359 @default.
- W3008772525 hasConceptScore W3008772525C33664856 @default.
- W3008772525 hasConceptScore W3008772525C526171541 @default.
- W3008772525 hasConceptScore W3008772525C54355233 @default.
- W3008772525 hasConceptScore W3008772525C55775858 @default.
- W3008772525 hasConceptScore W3008772525C558461103 @default.
- W3008772525 hasConceptScore W3008772525C62231903 @default.
- W3008772525 hasConceptScore W3008772525C71924100 @default.
- W3008772525 hasConceptScore W3008772525C86803240 @default.
- W3008772525 hasConceptScore W3008772525C98274493 @default.
- W3008772525 hasConceptScore W3008772525C99454951 @default.
- W3008772525 hasLocation W30087725251 @default.
- W3008772525 hasOpenAccess W3008772525 @default.
- W3008772525 hasPrimaryLocation W30087725251 @default.
- W3008772525 hasRelatedWork W155888914 @default.
- W3008772525 hasRelatedWork W2019490856 @default.
- W3008772525 hasRelatedWork W2032222462 @default.
- W3008772525 hasRelatedWork W2064330496 @default.
- W3008772525 hasRelatedWork W2118451906 @default.
- W3008772525 hasRelatedWork W2152358203 @default.
- W3008772525 hasRelatedWork W2163246271 @default.
- W3008772525 hasRelatedWork W2186278194 @default.
- W3008772525 hasRelatedWork W2224177558 @default.
- W3008772525 hasRelatedWork W2406584760 @default.
- W3008772525 hasRelatedWork W2470985001 @default.
- W3008772525 hasRelatedWork W2611335565 @default.
- W3008772525 hasRelatedWork W2616674049 @default.
- W3008772525 hasRelatedWork W2791336929 @default.
- W3008772525 hasRelatedWork W2885233292 @default.
- W3008772525 hasRelatedWork W2889363704 @default.
- W3008772525 hasRelatedWork W2970748344 @default.
- W3008772525 hasRelatedWork W2979390143 @default.
- W3008772525 hasRelatedWork W2990784790 @default.
- W3008772525 hasRelatedWork W3202770161 @default.
- W3008772525 isParatext "false" @default.
- W3008772525 isRetracted "false" @default.
- W3008772525 magId "3008772525" @default.
- W3008772525 workType "article" @default.