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- W3008815417 abstract "Non-alcoholic steatohepatitis (NASH) has been an emerging cause of hepatocellular carcinoma (HCC) over the past decade. The aim of this study is to investigate the survival (OS) outcomes of patients with HCC due to underlying NASH undergoing Yttrium-90 radioembolization (Y-90). An IRB-approved single-institution prospectively maintained Y-90 database (2003-2018) was searched for patients with NASH as the sole risk factor for cirrhosis. Patients with other underlying liver disease were excluded. Laboratory Toxicities per CTCAE v.5 were assessed within 60 days of Y-90. Survival was calculated by Kaplan-Meier method on both intention-to-treat (ITT) and censored to liver transplantation, then stratified by Child-Pugh (CP) and BCLC criteria. Univariate and multivariate analyses of predictors of censored survival were conducted using log-rank test and Cox proportional hazards, respectively. Statistical significance was set at (P <0.05). 62 patients with NASH cirrhosis underwent Y-90 for HCC; CPA (43%), B (50%), C (7%); BCLC A (35%), B (8%), C (50%), D (7%). Posttreatment grade 3/4 toxicities included albumin (5%), bilirubin (3%), AST (5%), and ALT (3%) and alkaline phosphatase (2%). Median censored OS was 16.3 months; CPA (22.6), B (15.0), and C (6.0); BCLC A (31.6), B (24.0), C (7.7), and D (6.0). Median ITT survival was 22.6 months; CP A (24.0), B (17.0), and C (6.0); BCLC A (36.3), B (32.4), C (14.3), D (6.0). Tumor size (P <0.0001), alpha-feto protein (AFP) (P <0.0001), ECOG (P = 0.04), and portal venous thrombus (P = 0.001) were predictors of censored survival in univariate analysis. AFP, tumor size, and ECOG remained significant predictors on multivariate analysis with hazard ratios 3.3, 3.8, and 2.4 respectively. Y-90 appears safe and effective in patients undergoing treatment for HCC secondary to NASH cirrhosis with low toxicity despite advanced underlying liver disease. This is an important concept as NASH increases in prevalence." @default.
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- W3008815417 date "2020-03-01" @default.
- W3008815417 modified "2023-10-18" @default.
- W3008815417 title "Abstract No. 716 Long-term outcomes of Yttrium-90 radioembolization for hepatocellular carcinoma due to underlying non-alcoholic steatohepatitis" @default.
- W3008815417 doi "https://doi.org/10.1016/j.jvir.2019.12.775" @default.
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