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• W3008894341 abstract "The arms race among microorganisms is a key driver in the evolution of not only the weapons but also defence mechanisms. Many Gram-negative bacteria use the type six secretion system (T6SS) to deliver toxic effectors directly into neighbouring cells. Defence against effectors requires cognate immunity proteins. However, here we show immunity-independent protection mediated by envelope stress responses in Escherichia coli and Vibrio cholerae against a V. cholerae T6SS effector, TseH. We demonstrate that TseH is a PAAR-dependent species-specific effector highly potent against Aeromonas species but not against its V. cholerae immunity mutant or E. coli. A structural analysis reveals TseH is probably a NlpC/P60-family cysteine endopeptidase. We determine that two envelope stress-response pathways, Rcs and BaeSR, protect E. coli from TseH toxicity by mechanisms including capsule synthesis. The two-component system WigKR (VxrAB) is critical for protecting V. cholerae from its own T6SS despite expressing immunity genes. WigR also regulates T6SS expression, suggesting a dual role in attack and defence. This deepens our understanding of how bacteria survive T6SS attacks and suggests that defence against the T6SS represents a major selective pressure driving the evolution of species-specific effectors and protective mechanisms mediated by envelope stress responses and capsule synthesis." @default.
• W3008894341 created "2020-03-06" @default.
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• W3008894341 date "2020-02-24" @default.
• W3008894341 modified "2023-10-18" @default.
• W3008894341 title "Envelope stress responses defend against type six secretion system attacks independently of immunity proteins" @default.
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• W3008894341 doi "https://doi.org/10.1038/s41564-020-0672-6" @default.
• W3008894341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7190449" @default.
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