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• W3009039921 endingPage "141" @default.
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• W3009039921 abstract "In this experimental animal study, we examined alterations in the degree of transcription of two microRNAs (miRs)—miR-21 and -223—in a Sprague-Dawley (SD) rat model of traumatic spinal cord injury (TSCI). Depending on the volume of the balloon catheter (V), a total of 75 male SD rats were divided into the three experimental groups: the sham group (n = 25; V = 0 μL), the mild group (n = 25; V = 20 μL), and the severe group (n = 25; V = 50 μL). Successful induction of TSCI was confirmed on both locomotor rating scale at 4 h and 1, 3 and 7 days post-lesion and histopathologic examinations. Then, RNA isolation and quantitative polymerase chain reaction (PCR) were performed. No differences in the level of miR-21 expression were found at the first time point studied (4 h post-lesion) between the three experimental groups, whereas such differences were significant at all the other time points (p < 0.05). Moreover, there were significant alterations in the level of miR-223 expression at all time points studied through all the experimental groups (p < 0.05). Furthermore, locomotor rating scale scores had a linear relationship with the level of miR-21 expression (R2 = 0.4363, Y = 1.661X + 3.096) and that of miR-223 one (R2 = 0.9104, Y = 0.8385X + 2.328). Taken together, we conclude that up-regulation of miR-21 and -223 might be closely associated with progression and the early course of TSCI, respectively." @default.
• W3009039921 created "2020-03-13" @default.
• W3009039921 creator A5022807309 @default.
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• W3009039921 date "2020-03-02" @default.
• W3009039921 modified "2023-09-27" @default.
• W3009039921 title "Up-regulation of MicroRNAs-21 and -223 in a Sprague-Dawley Rat Model of Traumatic Spinal Cord Injury" @default.
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• W3009039921 doi "https://doi.org/10.3390/brainsci10030141" @default.
• W3009039921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7139624" @default.
• W3009039921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32121653" @default.
• W3009039921 hasPublicationYear "2020" @default.
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