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- W3009062647 abstract "5540 Capsaicin is an active ingredient of chili peppers. We recently showed that capsaicin inhibited the growth of prostate cancer cells in vitro and in vivo. Here, we extended these studies and demonstrate that capsaicin has profound antiproliferative effects against breast cancer cells. Capsaicin inhibited the growth of estrogen receptor (ER)-positive (MCF-7, T47D, BT-474) and ER-negative (SK-BR-3, MDA-MB-231) breast cancer cell lines (ED50, 1x10-5 M - 5x10-5 M), due to an increase in apoptosis (from 5% in control cultures to 20% after 48 h treatment) as determined by annexin V staining. Expression of proteins involved in multiple signaling pathways that are important for breast cancer progression, were down-regulated by capsaicin. Specifically, expression of Akt, Her/Neu, and EGFR was decreased by incubation with capsaicin for 48 h in a dose-dependent manner (10-6 M to 2 x 10-4 M). Additionally, levels of these proteins were reduced to undetectable levels by 10-4 M capsaicin within 12 h of treatment. Decreases in expression of these proteins were not accompanied by decreases in their respective mRNA levels. In further experiments, reduced expression of EGFR caused by capsaicin in BT-474 cells led to diminished response to EGF. Phosphorylation of Erk in response to EGF was suppressed, and cells were less able to migrate towards the growth factor in Boyden chamber assays. Furthermore, capsaicin, when given orally, slowed by about 50% the growth of EGFR-positive MDA-MB-231 breast cancer cells grown as xenografts in nude mice. In summary, our data indicate that capsaicin is a novel regulator of EGFR and Her2 expression, and may provide therapeutic benefits for the management of ER+ and ER- breast cancers." @default.
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- W3009062647 date "2007-05-01" @default.
- W3009062647 modified "2023-09-26" @default.
- W3009062647 title "Capsaicin inhibits the growth of breast cancer cells and decreases expression of EGFR and Her2/Neu." @default.
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