FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009075722> ?p ?o ?g. }

• W3009075722 endingPage "1941" @default.
• W3009075722 startingPage "1925" @default.
• W3009075722 abstract "Abstract Polycyclic triterpenes are members of the terpene family produced by the cyclization of squalene. The most representative polycyclic triterpenes are hopanoids and sterols, the former are mostly found in bacteria, whereas the latter are largely limited to eukaryotes, albeit with a growing number of bacterial exceptions. Given their important role and omnipresence in most eukaryotes, contrasting with their scant representation in bacteria, sterol biosynthesis was long thought to be a eukaryotic innovation. Thus, their presence in some bacteria was deemed to be the result of lateral gene transfer from eukaryotes. Elucidating the origin and evolution of the polycyclic triterpene synthetic pathways is important to understand the role of these compounds in eukaryogenesis and their geobiological value as biomarkers in fossil records. Here, we have revisited the phylogenies of the main enzymes involved in triterpene synthesis, performing gene neighborhood analysis and phylogenetic profiling. Squalene can be biosynthesized by two different pathways containing the HpnCDE or Sqs proteins. Our results suggest that the HpnCDE enzymes are derived from carotenoid biosynthesis ones and that they assembled in an ancestral squalene pathway in bacteria, while remaining metabolically versatile. Conversely, the Sqs enzyme is prone to be involved in lateral gene transfer, and its emergence is possibly related to the specialization of squalene biosynthesis. The biosynthesis of hopanoids seems to be ancestral in the Bacteria domain. Moreover, no triterpene cyclases are found in Archaea, invoking a potential scenario in which eukaryotic genes for sterol biosynthesis assembled from ancestral bacterial contributions in early eukaryotic lineages." @default.
• W3009075722 created "2020-03-13" @default.
• W3009075722 creator A5030694212 @default.
• W3009075722 creator A5040059021 @default.
• W3009075722 creator A5059097089 @default.
• W3009075722 creator A5088734146 @default.
• W3009075722 date "2020-03-03" @default.
• W3009075722 modified "2023-10-03" @default.
• W3009075722 title "Origin and Evolution of Polycyclic Triterpene Synthesis" @default.
• W3009075722 cites W1539009580 @default.
• W3009075722 cites W1782601010 @default.
• W3009075722 cites W1881446470 @default.
• W3009075722 cites W1935233576 @default.
• W3009075722 cites W1972392332 @default.
• W3009075722 cites W1994359868 @default.
• W3009075722 cites W1996173391 @default.
• W3009075722 cites W1996345812 @default.
• W3009075722 cites W2006517236 @default.
• W3009075722 cites W2013932766 @default.
• W3009075722 cites W2025289529 @default.
• W3009075722 cites W2027834425 @default.
• W3009075722 cites W2050285934 @default.
• W3009075722 cites W2065235605 @default.
• W3009075722 cites W2067826968 @default.
• W3009075722 cites W2068056765 @default.
• W3009075722 cites W2073715954 @default.
• W3009075722 cites W2077499742 @default.
• W3009075722 cites W2087445881 @default.
• W3009075722 cites W2093929396 @default.
• W3009075722 cites W2097654444 @default.
• W3009075722 cites W2099440857 @default.
• W3009075722 cites W2109128618 @default.
• W3009075722 cites W2110827590 @default.
• W3009075722 cites W2111076637 @default.
• W3009075722 cites W2111647009 @default.
• W3009075722 cites W2115888213 @default.
• W3009075722 cites W2116744776 @default.
• W3009075722 cites W2121113752 @default.
• W3009075722 cites W2125723147 @default.
• W3009075722 cites W2129687319 @default.
• W3009075722 cites W2133334674 @default.
• W3009075722 cites W2135621733 @default.
• W3009075722 cites W2139134537 @default.
• W3009075722 cites W2140742875 @default.
• W3009075722 cites W2141052558 @default.
• W3009075722 cites W2143485490 @default.
• W3009075722 cites W2146058063 @default.
• W3009075722 cites W2153965936 @default.
• W3009075722 cites W2160199722 @default.
• W3009075722 cites W2160378127 @default.
• W3009075722 cites W2169783079 @default.
• W3009075722 cites W2170747616 @default.
• W3009075722 cites W2170758691 @default.
• W3009075722 cites W2315521535 @default.
• W3009075722 cites W2329165973 @default.
• W3009075722 cites W2344728688 @default.
• W3009075722 cites W2344940607 @default.
• W3009075722 cites W2472961533 @default.
• W3009075722 cites W2563340380 @default.
• W3009075722 cites W2578958622 @default.
• W3009075722 cites W2592590328 @default.
• W3009075722 cites W2594412381 @default.
• W3009075722 cites W2599649240 @default.
• W3009075722 cites W2614081736 @default.
• W3009075722 cites W2616601599 @default.
• W3009075722 cites W2621631905 @default.
• W3009075722 cites W2623492145 @default.
• W3009075722 cites W2746398248 @default.
• W3009075722 cites W2767716592 @default.
• W3009075722 cites W2787878862 @default.
• W3009075722 cites W2789211632 @default.
• W3009075722 cites W2800549213 @default.
• W3009075722 cites W2804227612 @default.
• W3009075722 cites W2808317478 @default.
• W3009075722 cites W2809850047 @default.
• W3009075722 cites W2886949501 @default.
• W3009075722 cites W2889019390 @default.
• W3009075722 cites W2900612307 @default.
• W3009075722 cites W2903239225 @default.
• W3009075722 cites W2918063357 @default.
• W3009075722 cites W2927961455 @default.
• W3009075722 cites W2943877814 @default.
• W3009075722 cites W2951464304 @default.
• W3009075722 cites W2954963193 @default.
• W3009075722 cites W2955393186 @default.
• W3009075722 doi "https://doi.org/10.1093/molbev/msaa054" @default.
• W3009075722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7306690" @default.
• W3009075722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32125435" @default.
• W3009075722 hasPublicationYear "2020" @default.
• W3009075722 type Work @default.
• W3009075722 sameAs 3009075722 @default.
• W3009075722 citedByCount "32" @default.
• W3009075722 countsByYear W30090757222020 @default.
• W3009075722 countsByYear W30090757222021 @default.
• W3009075722 countsByYear W30090757222022 @default.
• W3009075722 countsByYear W30090757222023 @default.
• W3009075722 crossrefType "journal-article" @default.
• W3009075722 hasAuthorship W3009075722A5030694212 @default.

• next