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• W3009102904 abstract "Summary Serotonin (5-HT) represents a quintessential neuromodulator, having been identified in nearly all animal species [ 1 ] where it functions in cognition [ 2 ], motor control [ 3 ], and sensory processing [ 4 ]. In the olfactory circuits of flies and mice, serotonin indirectly inhibits odor responses in olfactory receptor neurons (ORNs) via GABAergic local interneurons (LNs) [ 5 , 6 ]. However, the effects of 5-HT in olfaction are likely complicated, because multiple receptor subtypes are distributed throughout the olfactory bulb (OB) and antennal lobe (AL), the first layers of olfactory neuropil in mammals and insects, respectively [ 7 ]. For example, serotonin has a non-monotonic effect on odor responses in Drosophila projection neurons (PNs), where low concentrations suppress odor-evoked activity and higher concentrations boost PN responses [ 8 ]. Serotonin reaches the AL via the diffusion of paracrine 5-HT through the fly hemolymph [ 8 ] and by activation of the contralaterally projecting serotonin-immunoreactive deuterocerebral interneurons (CSDns): the only serotonergic cells that innervate the AL [ 9 , 10 ]. Concentration-dependent effects could arise by either the expression of multiple 5-HT receptors (5-HTRs) on the same cells or by populations of neurons dedicated to detecting serotonin at different concentrations. Here, we identify a population of LNs that express 5-HT7Rs exclusively to detect basal concentrations of 5-HT. These LNs inhibit PNs via GABAB receptors and mediate subtractive gain control. LNs expressing 5-HT7Rs are broadly tuned to odors and target every glomerulus in the antennal lobe. Our results demonstrate that serotonergic modulation at low concentrations targets a specific population of LNs to globally downregulate PN odor responses in the AL." @default.
• W3009102904 created "2020-03-13" @default.
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• W3009102904 date "2020-03-01" @default.
• W3009102904 modified "2023-10-17" @default.
• W3009102904 title "A Population of Interneurons Signals Changes in the Basal Concentration of Serotonin and Mediates Gain Control in the Drosophila Antennal Lobe" @default.
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• W3009102904 doi "https://doi.org/10.1016/j.cub.2020.01.018" @default.
• W3009102904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7133499" @default.
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