FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009131999> ?p ?o ?g. }

• W3009131999 endingPage "10" @default.
• W3009131999 startingPage "1" @default.
• W3009131999 abstract "Our previous study demonstrated that cadmium (Cd) is an effective inducer of mitophagy, which is mainly mediated by PINK1/Parkin pathway. However, the role of other mitophagy pathways in Cd-induced mitophagy remains elusive. The present study employed HeLa cells, lacking fully functional Parkin, as a cell model to study Parkin-independent mitophagy pathway induced by Cd. Our results showed that BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Bnip3L/NIX), an outer mitochondrial membrane mitophagy receptor, could provide an alternate pathway for Cd-induced mitophagy in HeLa cells. Specifically, 10 μM Cd for 12 h induced mitophagy in GM00637 and HeLa cells which was assessed by mitochondrial fusion to lysosomes and decreased expression of mitochondrial markers such as COX-IV and HSP60. Notably, in GM00637 cells, Cd-induced mitophagy was predominantly mediated by PINK1/Parkin pathway as evinced by translocation of Parkin to mitochondria. Interestingly, in HeLa cells, significant increase in NIX expression was occurred and mitophagy was induced under Cd exposure, suggesting NIX compensates lost role of Parkin in Cd-induced mitophagy in HeLa cells. These results were verified by knocking down NIX using siRNA in HeLa cells, which lead to abolished mitophagy process. Moreover, NIX phosphorylation at serine-81 significantly increased in cells treated with Cd implying that phosphorylation of NIX plays an important role in NIX-mediated mitophagy. These findings reveal a novel mechanism of Cd toxicity and suggest a compensatory role of NIX in Cd-induced mitophagy." @default.
• W3009131999 created "2020-03-13" @default.
• W3009131999 creator A5023672082 @default.
• W3009131999 creator A5043155449 @default.
• W3009131999 creator A5065560361 @default.
• W3009131999 creator A5075649738 @default.
• W3009131999 date "2020-06-01" @default.
• W3009131999 modified "2023-10-16" @default.
• W3009131999 title "NIX compensates lost role of parkin in cd-induced mitophagy in HeLa cells through phosphorylation" @default.
• W3009131999 cites W1957983000 @default.
• W3009131999 cites W1968843321 @default.
• W3009131999 cites W1969923532 @default.
• W3009131999 cites W1973352176 @default.
• W3009131999 cites W1977156258 @default.
• W3009131999 cites W1989293830 @default.
• W3009131999 cites W1993081339 @default.
• W3009131999 cites W1993135950 @default.
• W3009131999 cites W2001648286 @default.
• W3009131999 cites W2004861601 @default.
• W3009131999 cites W2006342727 @default.
• W3009131999 cites W2011451556 @default.
• W3009131999 cites W2019271853 @default.
• W3009131999 cites W2038976751 @default.
• W3009131999 cites W2042868758 @default.
• W3009131999 cites W2047242847 @default.
• W3009131999 cites W2057004250 @default.
• W3009131999 cites W2058813684 @default.
• W3009131999 cites W2062349310 @default.
• W3009131999 cites W2089434520 @default.
• W3009131999 cites W2093650005 @default.
• W3009131999 cites W2099875422 @default.
• W3009131999 cites W2103230459 @default.
• W3009131999 cites W2103562463 @default.
• W3009131999 cites W2136388422 @default.
• W3009131999 cites W2139215121 @default.
• W3009131999 cites W2139446098 @default.
• W3009131999 cites W2164945122 @default.
• W3009131999 cites W2524324468 @default.
• W3009131999 cites W2593974461 @default.
• W3009131999 cites W2605825818 @default.
• W3009131999 cites W2615429593 @default.
• W3009131999 cites W2735590725 @default.
• W3009131999 cites W2749164324 @default.
• W3009131999 cites W2798152513 @default.
• W3009131999 cites W2806233704 @default.
• W3009131999 cites W2886231497 @default.
• W3009131999 doi "https://doi.org/10.1016/j.toxlet.2020.03.001" @default.
• W3009131999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32142837" @default.
• W3009131999 hasPublicationYear "2020" @default.
• W3009131999 type Work @default.
• W3009131999 sameAs 3009131999 @default.
• W3009131999 citedByCount "18" @default.
• W3009131999 countsByYear W30091319992020 @default.
• W3009131999 countsByYear W30091319992021 @default.
• W3009131999 countsByYear W30091319992022 @default.
• W3009131999 countsByYear W30091319992023 @default.
• W3009131999 crossrefType "journal-article" @default.
• W3009131999 hasAuthorship W3009131999A5023672082 @default.
• W3009131999 hasAuthorship W3009131999A5043155449 @default.
• W3009131999 hasAuthorship W3009131999A5065560361 @default.
• W3009131999 hasAuthorship W3009131999A5075649738 @default.
• W3009131999 hasConcept C104317684 @default.
• W3009131999 hasConcept C11960822 @default.
• W3009131999 hasConcept C126322002 @default.
• W3009131999 hasConcept C1491633281 @default.
• W3009131999 hasConcept C185592680 @default.
• W3009131999 hasConcept C190283241 @default.
• W3009131999 hasConcept C203522944 @default.
• W3009131999 hasConcept C25602115 @default.
• W3009131999 hasConcept C2776804853 @default.
• W3009131999 hasConcept C2777366897 @default.
• W3009131999 hasConcept C2777668072 @default.
• W3009131999 hasConcept C2779134260 @default.
• W3009131999 hasConcept C2779324830 @default.
• W3009131999 hasConcept C2779734285 @default.
• W3009131999 hasConcept C28859421 @default.
• W3009131999 hasConcept C55493867 @default.
• W3009131999 hasConcept C71924100 @default.
• W3009131999 hasConcept C86803240 @default.
• W3009131999 hasConcept C95444343 @default.
• W3009131999 hasConceptScore W3009131999C104317684 @default.
• W3009131999 hasConceptScore W3009131999C11960822 @default.
• W3009131999 hasConceptScore W3009131999C126322002 @default.
• W3009131999 hasConceptScore W3009131999C1491633281 @default.
• W3009131999 hasConceptScore W3009131999C185592680 @default.
• W3009131999 hasConceptScore W3009131999C190283241 @default.
• W3009131999 hasConceptScore W3009131999C203522944 @default.
• W3009131999 hasConceptScore W3009131999C25602115 @default.
• W3009131999 hasConceptScore W3009131999C2776804853 @default.
• W3009131999 hasConceptScore W3009131999C2777366897 @default.
• W3009131999 hasConceptScore W3009131999C2777668072 @default.
• W3009131999 hasConceptScore W3009131999C2779134260 @default.
• W3009131999 hasConceptScore W3009131999C2779324830 @default.
• W3009131999 hasConceptScore W3009131999C2779734285 @default.
• W3009131999 hasConceptScore W3009131999C28859421 @default.
• W3009131999 hasConceptScore W3009131999C55493867 @default.
• W3009131999 hasConceptScore W3009131999C71924100 @default.
• W3009131999 hasConceptScore W3009131999C86803240 @default.

• next