FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009133055> ?p ?o ?g. }

• W3009133055 endingPage "581" @default.
• W3009133055 startingPage "575" @default.
• W3009133055 abstract "Abstract Purpose In the late1990s, reacting to the outbreak of bovine spongiform encephalopathy (BSE) in the United Kingdom that caused a new variant of Creutzfeldt‐Jakob disease (vCJD) in humans, manufacturers withdrew bovine heparin from the market in the United States. There have been growing concerns about the adequate supply and safety of porcine heparin. Since the BSE epidemic has been declining markedly, the US Food and Drug Administration reevaluates the vCJD risk via use of bovine heparin. Methods We developed a computational model to estimate the vCJD risk to patients receiving bovine heparin injections. The model incorporated information including BSE prevalence, infectivity levels in the intestines, manufacturing batch size, yield of heparin, reduction in infectivity by manufacturing process, and the dose‐response relationship. Results The model estimates a median risk of vCJD infection from a single intravenous dose (10 000 USP units) of heparin made from US‐sourced bovine intestines to be 6.9 × 10 −9 (2.5‐97.fifth percentile: 1.5 × 10 −9 ‐4.3 × 10 −8 ), a risk of 1 in 145 million, and 4.6 × 10 −8 (2.5‐97.fifth percentile: 1.1 × 10 −8 ‐2.6 × 10 −7 ), a risk of 1 in 22 million for Canada‐sourced products. The model estimates a median risk of 1.4 × 10 −7 (2.5‐97.fifth percentile: 2.9 × 10 −8 ‐9.3 × 10 −7 ) and 9.6 × 10 −7 (2.5‐97.fifth percentile: 2.1 × 10 −7 ‐5.6 × 10 −6 ) for a typical treatment for venous thromboembolism (infusion of 2‐4 doses daily per week) using US‐sourced and Canada‐sourced bovine heparin, respectively. Conclusions The model estimates the vCJD risk from use of heparin when appropriately manufactured from US or Canadian cattle is likely small. The model and conclusions should not be applied to other medicinal products manufactured using bovine‐derived materials." @default.
• W3009133055 created "2020-03-13" @default.
• W3009133055 creator A5008758398 @default.
• W3009133055 creator A5009144198 @default.
• W3009133055 creator A5019728674 @default.
• W3009133055 creator A5020273385 @default.
• W3009133055 creator A5027085611 @default.
• W3009133055 creator A5049614741 @default.
• W3009133055 creator A5051465338 @default.
• W3009133055 creator A5067036159 @default.
• W3009133055 creator A5068016624 @default.
• W3009133055 creator A5076855289 @default.
• W3009133055 creator A5087332112 @default.
• W3009133055 date "2020-03-05" @default.
• W3009133055 modified "2023-09-27" @default.
• W3009133055 title "Assessment of risk of variant creutzfeldt‐Jakob disease (vCJD) from use of bovine heparin" @default.
• W3009133055 cites W146472407 @default.
• W3009133055 cites W1995397433 @default.
• W3009133055 cites W2009961932 @default.
• W3009133055 cites W2038142248 @default.
• W3009133055 cites W2074255015 @default.
• W3009133055 cites W2082573664 @default.
• W3009133055 cites W2083451509 @default.
• W3009133055 cites W2097366202 @default.
• W3009133055 cites W2124692225 @default.
• W3009133055 cites W2159949612 @default.
• W3009133055 cites W2412323428 @default.
• W3009133055 cites W2553309354 @default.
• W3009133055 cites W2580139933 @default.
• W3009133055 cites W2591685856 @default.
• W3009133055 doi "https://doi.org/10.1002/pds.4982" @default.
• W3009133055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32134162" @default.
• W3009133055 hasPublicationYear "2020" @default.
• W3009133055 type Work @default.
• W3009133055 sameAs 3009133055 @default.
• W3009133055 citedByCount "3" @default.
• W3009133055 countsByYear W30091330552020 @default.
• W3009133055 countsByYear W30091330552023 @default.
• W3009133055 crossrefType "journal-article" @default.
• W3009133055 hasAuthorship W3009133055A5008758398 @default.
• W3009133055 hasAuthorship W3009133055A5009144198 @default.
• W3009133055 hasAuthorship W3009133055A5019728674 @default.
• W3009133055 hasAuthorship W3009133055A5020273385 @default.
• W3009133055 hasAuthorship W3009133055A5027085611 @default.
• W3009133055 hasAuthorship W3009133055A5049614741 @default.
• W3009133055 hasAuthorship W3009133055A5051465338 @default.
• W3009133055 hasAuthorship W3009133055A5067036159 @default.
• W3009133055 hasAuthorship W3009133055A5068016624 @default.
• W3009133055 hasAuthorship W3009133055A5076855289 @default.
• W3009133055 hasAuthorship W3009133055A5087332112 @default.
• W3009133055 hasConcept C105795698 @default.
• W3009133055 hasConcept C106358424 @default.
• W3009133055 hasConcept C116675565 @default.
• W3009133055 hasConcept C122048520 @default.
• W3009133055 hasConcept C126322002 @default.
• W3009133055 hasConcept C159047783 @default.
• W3009133055 hasConcept C2522874641 @default.
• W3009133055 hasConcept C2777557582 @default.
• W3009133055 hasConcept C2779134260 @default.
• W3009133055 hasConcept C2781131914 @default.
• W3009133055 hasConcept C3019804061 @default.
• W3009133055 hasConcept C33923547 @default.
• W3009133055 hasConcept C71924100 @default.
• W3009133055 hasConceptScore W3009133055C105795698 @default.
• W3009133055 hasConceptScore W3009133055C106358424 @default.
• W3009133055 hasConceptScore W3009133055C116675565 @default.
• W3009133055 hasConceptScore W3009133055C122048520 @default.
• W3009133055 hasConceptScore W3009133055C126322002 @default.
• W3009133055 hasConceptScore W3009133055C159047783 @default.
• W3009133055 hasConceptScore W3009133055C2522874641 @default.
• W3009133055 hasConceptScore W3009133055C2777557582 @default.
• W3009133055 hasConceptScore W3009133055C2779134260 @default.
• W3009133055 hasConceptScore W3009133055C2781131914 @default.
• W3009133055 hasConceptScore W3009133055C3019804061 @default.
• W3009133055 hasConceptScore W3009133055C33923547 @default.
• W3009133055 hasConceptScore W3009133055C71924100 @default.
• W3009133055 hasIssue "5" @default.
• W3009133055 hasLocation W30091330551 @default.
• W3009133055 hasOpenAccess W3009133055 @default.
• W3009133055 hasPrimaryLocation W30091330551 @default.
• W3009133055 hasRelatedWork W1963635623 @default.
• W3009133055 hasRelatedWork W2007476588 @default.
• W3009133055 hasRelatedWork W2020098551 @default.
• W3009133055 hasRelatedWork W2029332005 @default.
• W3009133055 hasRelatedWork W2056558537 @default.
• W3009133055 hasRelatedWork W2100785397 @default.
• W3009133055 hasRelatedWork W2144337714 @default.
• W3009133055 hasRelatedWork W2153411152 @default.
• W3009133055 hasRelatedWork W3045872790 @default.
• W3009133055 hasRelatedWork W3140451089 @default.
• W3009133055 hasVolume "29" @default.
• W3009133055 isParatext "false" @default.
• W3009133055 isRetracted "false" @default.
• W3009133055 magId "3009133055" @default.
• W3009133055 workType "article" @default.