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• W3009146870 abstract "Although a number of transcription factors have been reported to be involved in HPV gene expression, little is known about the cofactors that support HPV transcription. In this study, we demonstrate that the transcriptional cofactor VGLL1 plays a prominent role in HPV early gene expression, dependent on its association with the transcription factor TEAD1. Whereas TEAD1 is ubiquitously expressed in a variety of tissues, VGLL1 displays tissue-specific expression and is implicated in the development and differentiation of epithelial lineage tissues, where HPV gene expression occurs. Our results suggest that VGLL1 may contribute to the epithelial specificity of HPV gene expression, providing new insights into the mechanisms that regulate HPV infection. Further, VGLL1 is also critical for the growth of cervical cancer cells and may represent a novel therapeutic target for HPV-associated cancers." @default.
• W3009146870 created "2020-03-13" @default.
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• W3009146870 date "2020-05-04" @default.
• W3009146870 modified "2023-10-16" @default.
• W3009146870 title "The Transcriptional Cofactor VGLL1 Drives Transcription of Human Papillomavirus Early Genes via TEAD1" @default.
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• W3009146870 doi "https://doi.org/10.1128/jvi.01945-19" @default.
• W3009146870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7199408" @default.
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• W3009146870 hasPublicationYear "2020" @default.
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