FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009164530> ?p ?o ?g. }

• W3009164530 endingPage "153473541990092" @default.
• W3009164530 startingPage "153473541990092" @default.
• W3009164530 abstract "Background: Malignant glioma is a lethal brain tumor that is highly resistant to standard therapy. Our research aims to explore the suppressive effects of nitidine chloride (NC) on gliomas and the mechanisms involved, showing that it is a potential agent for integrative therapy of gliomas. Methods: After glioma cells were treated with NC, several experiments were performed to evaluate NC’s antitumor effects. CCK-8 assay was used to detect viability. Transwell and 3-dimensional spheroid invasion assays were used to evaluate motility of glioma in vitro, and the sphere-formation assay showed NC’s influence on glioma stem cells. Apoptosis and intracellular reactive oxygen species were measured by means of flow cytometry. Subcellular structures were observed through transmission electron microscopy. Western blot analysis reflected expression of endoplasmic reticulum (ER) stress and epithelial-mesenchymal transition (EMT) marker proteins. An orthotopic xenograft model was established to investigate the tumor suppressive effects in vivo. Results: Nitidine chloride inhibited glioma cell migration and invasion in vitro, downregulated the EMT proteins, and suppressed sphere formation of glioma stem cells. Furthermore, NC induced persistent ER stress that contributed to apoptosis and reactive oxygen species production. The xenograft model showed that NC effectively restricted glioma growth and invasion in vivo. Furthermore, we confirmed the signaling pathways that ER stress downregulates C/EBPβ and slug, as well as inhibition of the AKT/GSK3β/β-catenin axis caused by NC, in U-87 MG. Conclusion: We demonstrated that NC inhibits gliomas in vitro and in vivo by activating ER stress and downregulating EMT, which provides a basis for glioma therapy." @default.
• W3009164530 created "2020-03-13" @default.
• W3009164530 creator A5024184624 @default.
• W3009164530 creator A5026427868 @default.
• W3009164530 creator A5031573832 @default.
• W3009164530 creator A5037815059 @default.
• W3009164530 creator A5039489060 @default.
• W3009164530 creator A5039607268 @default.
• W3009164530 creator A5058425436 @default.
• W3009164530 creator A5059384209 @default.
• W3009164530 creator A5072145512 @default.
• W3009164530 creator A5074942308 @default.
• W3009164530 date "2020-01-01" @default.
• W3009164530 modified "2023-10-18" @default.
• W3009164530 title "Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition" @default.
• W3009164530 cites W1840737287 @default.
• W3009164530 cites W1964825240 @default.
• W3009164530 cites W1980643223 @default.
• W3009164530 cites W1988553303 @default.
• W3009164530 cites W1997005119 @default.
• W3009164530 cites W2007954304 @default.
• W3009164530 cites W2024672608 @default.
• W3009164530 cites W2045579721 @default.
• W3009164530 cites W2069364842 @default.
• W3009164530 cites W2084109336 @default.
• W3009164530 cites W2123434257 @default.
• W3009164530 cites W2135465849 @default.
• W3009164530 cites W2135793606 @default.
• W3009164530 cites W2139112064 @default.
• W3009164530 cites W2150202137 @default.
• W3009164530 cites W2154589460 @default.
• W3009164530 cites W2316856344 @default.
• W3009164530 cites W2415492320 @default.
• W3009164530 cites W2419900390 @default.
• W3009164530 cites W2487781536 @default.
• W3009164530 cites W2596943683 @default.
• W3009164530 cites W2604627398 @default.
• W3009164530 cites W2740187183 @default.
• W3009164530 cites W2748120903 @default.
• W3009164530 cites W2771831687 @default.
• W3009164530 cites W2772881509 @default.
• W3009164530 cites W2777578757 @default.
• W3009164530 cites W2808979164 @default.
• W3009164530 cites W2883706067 @default.
• W3009164530 cites W4250899941 @default.
• W3009164530 doi "https://doi.org/10.1177/1534735419900927" @default.
• W3009164530 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7057402" @default.
• W3009164530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32129091" @default.
• W3009164530 hasPublicationYear "2020" @default.
• W3009164530 type Work @default.
• W3009164530 sameAs 3009164530 @default.
• W3009164530 citedByCount "3" @default.
• W3009164530 countsByYear W30091645302021 @default.
• W3009164530 countsByYear W30091645302023 @default.
• W3009164530 crossrefType "journal-article" @default.
• W3009164530 hasAuthorship W3009164530A5024184624 @default.
• W3009164530 hasAuthorship W3009164530A5026427868 @default.
• W3009164530 hasAuthorship W3009164530A5031573832 @default.
• W3009164530 hasAuthorship W3009164530A5037815059 @default.
• W3009164530 hasAuthorship W3009164530A5039489060 @default.
• W3009164530 hasAuthorship W3009164530A5039607268 @default.
• W3009164530 hasAuthorship W3009164530A5058425436 @default.
• W3009164530 hasAuthorship W3009164530A5059384209 @default.
• W3009164530 hasAuthorship W3009164530A5072145512 @default.
• W3009164530 hasAuthorship W3009164530A5074942308 @default.
• W3009164530 hasBestOaLocation W30091645301 @default.
• W3009164530 hasConcept C104317684 @default.
• W3009164530 hasConcept C127561419 @default.
• W3009164530 hasConcept C128473837 @default.
• W3009164530 hasConcept C139447449 @default.
• W3009164530 hasConcept C150903083 @default.
• W3009164530 hasConcept C153911025 @default.
• W3009164530 hasConcept C158617107 @default.
• W3009164530 hasConcept C185592680 @default.
• W3009164530 hasConcept C190283241 @default.
• W3009164530 hasConcept C198826908 @default.
• W3009164530 hasConcept C207001950 @default.
• W3009164530 hasConcept C2776415932 @default.
• W3009164530 hasConcept C2778227246 @default.
• W3009164530 hasConcept C502942594 @default.
• W3009164530 hasConcept C553184892 @default.
• W3009164530 hasConcept C55493867 @default.
• W3009164530 hasConcept C75217442 @default.
• W3009164530 hasConcept C76419328 @default.
• W3009164530 hasConcept C86554907 @default.
• W3009164530 hasConcept C86803240 @default.
• W3009164530 hasConcept C95444343 @default.
• W3009164530 hasConceptScore W3009164530C104317684 @default.
• W3009164530 hasConceptScore W3009164530C127561419 @default.
• W3009164530 hasConceptScore W3009164530C128473837 @default.
• W3009164530 hasConceptScore W3009164530C139447449 @default.
• W3009164530 hasConceptScore W3009164530C150903083 @default.
• W3009164530 hasConceptScore W3009164530C153911025 @default.
• W3009164530 hasConceptScore W3009164530C158617107 @default.
• W3009164530 hasConceptScore W3009164530C185592680 @default.
• W3009164530 hasConceptScore W3009164530C190283241 @default.
• W3009164530 hasConceptScore W3009164530C198826908 @default.
• W3009164530 hasConceptScore W3009164530C207001950 @default.

• next