Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009227617> ?p ?o ?g. }
- W3009227617 endingPage "367" @default.
- W3009227617 startingPage "352" @default.
- W3009227617 abstract "C-type lectin-like receptor 2 (CLEC-2) is considered as a potential drug target in settings of wound healing, inflammation, and infection. A potential barrier to this is evidence that CLEC-2 and its ligand podoplanin play a critical role in preventing lymphatic vessel blood filling in mice throughout life. In this study, this aspect of CLEC-2/podoplanin function is investigated in more detail using new and established mouse models of CLEC-2 and podoplanin deficiency, and models of acute and chronic vascular remodeling. We report that CLEC-2 expression on platelets is not required to maintain a barrier between the blood and lymphatic systems in unchallenged mice, post-development. However, under certain conditions of chronic vascular remodeling, such as during tumorigenesis, deficiency in CLEC-2 can lead to lymphatic vessel blood filling. These data provide a new understanding of the function of CLEC-2 in adult mice and confirm the essential nature of CLEC-2-driven platelet activation in vascular developmental programs. This work expands our understanding of how lymphatic blood filling is prevented by CLEC-2-dependent platelet function and provides a context for the development of safe targeting strategies for CLEC-2 and podoplanin." @default.
- W3009227617 created "2020-03-13" @default.
- W3009227617 creator A5003349503 @default.
- W3009227617 creator A5005426443 @default.
- W3009227617 creator A5008888080 @default.
- W3009227617 creator A5009614528 @default.
- W3009227617 creator A5046557008 @default.
- W3009227617 creator A5055918130 @default.
- W3009227617 creator A5057799772 @default.
- W3009227617 creator A5060660071 @default.
- W3009227617 creator A5064699315 @default.
- W3009227617 creator A5081460102 @default.
- W3009227617 creator A5081956660 @default.
- W3009227617 creator A5083653940 @default.
- W3009227617 creator A5083972865 @default.
- W3009227617 creator A5089040494 @default.
- W3009227617 date "2020-03-04" @default.
- W3009227617 modified "2023-10-16" @default.
- W3009227617 title "Lymphatic blood filling in CLEC-2-deficient mouse models" @default.
- W3009227617 cites W1496074686 @default.
- W3009227617 cites W1519030262 @default.
- W3009227617 cites W1636539495 @default.
- W3009227617 cites W1769654684 @default.
- W3009227617 cites W1940673072 @default.
- W3009227617 cites W1965130082 @default.
- W3009227617 cites W1978489538 @default.
- W3009227617 cites W1980934196 @default.
- W3009227617 cites W1994323367 @default.
- W3009227617 cites W1996530649 @default.
- W3009227617 cites W1997508706 @default.
- W3009227617 cites W2004755955 @default.
- W3009227617 cites W2009726341 @default.
- W3009227617 cites W2018279532 @default.
- W3009227617 cites W2020051447 @default.
- W3009227617 cites W2025009029 @default.
- W3009227617 cites W2025105451 @default.
- W3009227617 cites W2025532285 @default.
- W3009227617 cites W2034027385 @default.
- W3009227617 cites W2035465177 @default.
- W3009227617 cites W2038336599 @default.
- W3009227617 cites W2050878137 @default.
- W3009227617 cites W2081830302 @default.
- W3009227617 cites W2082630087 @default.
- W3009227617 cites W2084558110 @default.
- W3009227617 cites W2085969265 @default.
- W3009227617 cites W2091977407 @default.
- W3009227617 cites W2092403241 @default.
- W3009227617 cites W2094866161 @default.
- W3009227617 cites W2096113051 @default.
- W3009227617 cites W2100261477 @default.
- W3009227617 cites W2116298485 @default.
- W3009227617 cites W2122156463 @default.
- W3009227617 cites W2127953803 @default.
- W3009227617 cites W2139594918 @default.
- W3009227617 cites W2139921573 @default.
- W3009227617 cites W2142739945 @default.
- W3009227617 cites W2148682579 @default.
- W3009227617 cites W2160781113 @default.
- W3009227617 cites W2170619728 @default.
- W3009227617 cites W2172253185 @default.
- W3009227617 cites W2177802181 @default.
- W3009227617 cites W2178159185 @default.
- W3009227617 cites W2260984315 @default.
- W3009227617 cites W2471071303 @default.
- W3009227617 cites W2547822128 @default.
- W3009227617 cites W2586696305 @default.
- W3009227617 cites W2746485402 @default.
- W3009227617 cites W2749760732 @default.
- W3009227617 cites W2750385556 @default.
- W3009227617 cites W2771149535 @default.
- W3009227617 cites W2772071913 @default.
- W3009227617 cites W2781650509 @default.
- W3009227617 cites W2785579092 @default.
- W3009227617 cites W2786753426 @default.
- W3009227617 cites W2790453539 @default.
- W3009227617 cites W2792751203 @default.
- W3009227617 cites W2807668001 @default.
- W3009227617 cites W2883175618 @default.
- W3009227617 cites W2898780408 @default.
- W3009227617 cites W2900874062 @default.
- W3009227617 cites W2907399917 @default.
- W3009227617 cites W2907613123 @default.
- W3009227617 cites W2912022110 @default.
- W3009227617 cites W2912342964 @default.
- W3009227617 cites W2914161826 @default.
- W3009227617 cites W2914962834 @default.
- W3009227617 cites W2915813634 @default.
- W3009227617 cites W2949851288 @default.
- W3009227617 cites W2953811398 @default.
- W3009227617 cites W2954797621 @default.
- W3009227617 cites W2995308462 @default.
- W3009227617 cites W4234185730 @default.
- W3009227617 cites W4249606224 @default.
- W3009227617 doi "https://doi.org/10.1080/09537104.2020.1734784" @default.
- W3009227617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8443399" @default.
- W3009227617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32129691" @default.
- W3009227617 hasPublicationYear "2020" @default.
- W3009227617 type Work @default.