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• W3009242011 abstract "Abstract The mesolimbic dopamine system comprises distinct compartments supporting different functions in learning and motivation. Less well understood is how complex addiction-related behaviors emerge from activity patterns across these compartments. Here we show how different forms of relapse to alcohol-seeking are assembled from activity across the ventral tegmental area and the nucleus accumbens. Using gCaMP and dLight fibre photometry, we show that self-administration and two forms of relapse (renewal/context-induced reinstatement and reacquisition) are associated with recruitment across the mesolimbic dopamine system. Using a variety of interventions, we show that this activity is causal to both forms of relapse. Finally, we use dissimilarity matrices to identify mesolimbic dopamine signatures of self-administration, extinction, and relapse. We show that signatures of relapse can be identified from heterogeneous activity profiles across the mesolimbic dopamine system and that these signatures differ for different forms of relapse." @default.
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• W3009242011 date "2020-03-08" @default.
• W3009242011 modified "2023-09-28" @default.
• W3009242011 title "The mesolimbic dopamine signatures of relapse to alcohol-seeking" @default.
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• W3009242011 doi "https://doi.org/10.1101/2020.03.06.981605" @default.
• W3009242011 hasPublicationYear "2020" @default.
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