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- W3009249789 abstract "Liver cancer is the fifth most common cancer and the second most common cause of cancer-related death worldwide. The incidence of liver cancer varies geographically and is highest in Africa and Asia. These regions also have a high prevalence of hepatitis B virus (HBV) and hepatitis C virus infections, which are the most important causes of chronic liver diseases. Local ablation, liver resection, and orthotopic liver transplantation are considered potentially curative treatment modalities for patients with hepatocellular carcinoma (HCC). Despite these curative-intent approaches, tumour recurrence occurs in 50–70% of patients within 5 years of surgery, either as early intrahepatic metastases or as new HCC foci that develop in the liver remnants. No adjuvant treatment has shown convincing efficacy in HCC thus far. Therefore, considering that a high number of patients develop recurrence, there is an evident unmet clinical need. Adjuvant 131I-metuximab for hepatocellular carcinoma after liver resection: a randomised, controlled, multicentre, open-label, phase 2 trialAdjuvant 131I-metuximab treatment significantly improved the 5-year RFS of patients after hepatectomy for HCC tumours expressing CD147. This treatment was well tolerated by patients. Full-Text PDF" @default.
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- W3009249789 date "2020-06-01" @default.
- W3009249789 modified "2023-09-27" @default.
- W3009249789 title "Adjuvant 131I-metuximab in hepatocellular carcinoma: a new option for an old drug?" @default.
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- W3009249789 doi "https://doi.org/10.1016/s2468-1253(20)30004-2" @default.
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