Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009276656> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W3009276656 abstract "The role of the immune response to cyathostomin infections in horses remains unknown. Intestinal goblet cell hyperplasia has previously been noted as a component in cyathostomin infection; however, the function is unclear. The goal of this study was to evaluate the local and systemic gene expression to cyathostomin infections following larvicidal treatment and explore their relation to goblet cells.Thirty-six ponies with naturally acquired cyathostomin infections were randomly allocated into three groups: fenbendazole-treated (10 mg/kg PO 5 days), moxidectin-treated (0.4 mg/kg PO once) and untreated control. Whole blood from all horses was collected weekly, and tissue samples from the large intestine collected during necropsy at 2 and 5 weeks post-treatment (WPT). Gene expression of interleukin (IL)-4, IL-5, IL-6, IL-10, IL-13, IL-17A, IL-22, IFN-γ, resistin-like molecule beta (RELM-β), Mucin 2 (MUC2) and tumour necrosis factor (TNF)-α was measured using qRT-PCR. There were statistically significant linear correlations between luminal worm burdens and MUC2 (r = -.2358) and RELM-β (r = -.2261).This suggests an active role of immune system post-treatment in parasite expulsion, specifically in goblet cells, and that the organs respond differently to treatment and the larvae themselves. This may have implications in the disease process and treatment." @default.
- W3009276656 created "2020-03-13" @default.
- W3009276656 creator A5040885125 @default.
- W3009276656 creator A5041791528 @default.
- W3009276656 creator A5053786618 @default.
- W3009276656 creator A5060242817 @default.
- W3009276656 creator A5080276424 @default.
- W3009276656 date "2020-03-20" @default.
- W3009276656 modified "2023-09-26" @default.
- W3009276656 title "Cytokine and goblet cell gene expression in equine cyathostomin infection and larvicidal anthelmintic therapy" @default.
- W3009276656 cites W1805997582 @default.
- W3009276656 cites W1963707258 @default.
- W3009276656 cites W1966599992 @default.
- W3009276656 cites W1967729566 @default.
- W3009276656 cites W1984674626 @default.
- W3009276656 cites W1987650422 @default.
- W3009276656 cites W2006386117 @default.
- W3009276656 cites W2023595195 @default.
- W3009276656 cites W2027024639 @default.
- W3009276656 cites W2049914659 @default.
- W3009276656 cites W2056795725 @default.
- W3009276656 cites W2061710854 @default.
- W3009276656 cites W2082665117 @default.
- W3009276656 cites W2089790135 @default.
- W3009276656 cites W2101500685 @default.
- W3009276656 cites W2101760435 @default.
- W3009276656 cites W2107277218 @default.
- W3009276656 cites W2112516644 @default.
- W3009276656 cites W2140273368 @default.
- W3009276656 cites W2201685090 @default.
- W3009276656 cites W2405524070 @default.
- W3009276656 cites W2744201297 @default.
- W3009276656 cites W2745962991 @default.
- W3009276656 cites W2765211209 @default.
- W3009276656 cites W2792848680 @default.
- W3009276656 cites W2889030481 @default.
- W3009276656 doi "https://doi.org/10.1111/pim.12709" @default.
- W3009276656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32145074" @default.
- W3009276656 hasPublicationYear "2020" @default.
- W3009276656 type Work @default.
- W3009276656 sameAs 3009276656 @default.
- W3009276656 citedByCount "6" @default.
- W3009276656 countsByYear W30092766562020 @default.
- W3009276656 countsByYear W30092766562022 @default.
- W3009276656 countsByYear W30092766562023 @default.
- W3009276656 crossrefType "journal-article" @default.
- W3009276656 hasAuthorship W3009276656A5040885125 @default.
- W3009276656 hasAuthorship W3009276656A5041791528 @default.
- W3009276656 hasAuthorship W3009276656A5053786618 @default.
- W3009276656 hasAuthorship W3009276656A5060242817 @default.
- W3009276656 hasAuthorship W3009276656A5080276424 @default.
- W3009276656 hasConcept C104317684 @default.
- W3009276656 hasConcept C150194340 @default.
- W3009276656 hasConcept C18903297 @default.
- W3009276656 hasConcept C203014093 @default.
- W3009276656 hasConcept C2776186584 @default.
- W3009276656 hasConcept C2776908094 @default.
- W3009276656 hasConcept C2778690821 @default.
- W3009276656 hasConcept C55493867 @default.
- W3009276656 hasConcept C86803240 @default.
- W3009276656 hasConcept C8891405 @default.
- W3009276656 hasConceptScore W3009276656C104317684 @default.
- W3009276656 hasConceptScore W3009276656C150194340 @default.
- W3009276656 hasConceptScore W3009276656C18903297 @default.
- W3009276656 hasConceptScore W3009276656C203014093 @default.
- W3009276656 hasConceptScore W3009276656C2776186584 @default.
- W3009276656 hasConceptScore W3009276656C2776908094 @default.
- W3009276656 hasConceptScore W3009276656C2778690821 @default.
- W3009276656 hasConceptScore W3009276656C55493867 @default.
- W3009276656 hasConceptScore W3009276656C86803240 @default.
- W3009276656 hasConceptScore W3009276656C8891405 @default.
- W3009276656 hasIssue "6" @default.
- W3009276656 hasLocation W30092766561 @default.
- W3009276656 hasLocation W30092766562 @default.
- W3009276656 hasOpenAccess W3009276656 @default.
- W3009276656 hasPrimaryLocation W30092766561 @default.
- W3009276656 hasRelatedWork W181678093 @default.
- W3009276656 hasRelatedWork W1993985418 @default.
- W3009276656 hasRelatedWork W2005666125 @default.
- W3009276656 hasRelatedWork W2047209980 @default.
- W3009276656 hasRelatedWork W2095433947 @default.
- W3009276656 hasRelatedWork W3017248443 @default.
- W3009276656 hasRelatedWork W3185323772 @default.
- W3009276656 hasRelatedWork W2178696297 @default.
- W3009276656 hasRelatedWork W2185732136 @default.
- W3009276656 hasRelatedWork W2396811992 @default.
- W3009276656 hasVolume "42" @default.
- W3009276656 isParatext "false" @default.
- W3009276656 isRetracted "false" @default.
- W3009276656 magId "3009276656" @default.
- W3009276656 workType "article" @default.