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- W3009276911 abstract "We assessed the mechanism of mammalian breathing rhythmogenesis in the preBötzinger complex (preBötC) in vitro, where experimental tests remain inconsistent with hypotheses of canonical rhythmogenic cellular or synaptic mechanisms, i.e., pacemaker neurons or inhibition. Under rhythmic conditions, in each cycle, an inspiratory burst emerges as (presumptive) preBötC rhythmogenic neurons transition from aperiodic uncorrelated population spike activity to become increasingly synchronized during preinspiration (for ∼50-500 ms), which can trigger inspiratory bursts that propagate to motoneurons. In nonrhythmic conditions, antagonizing GABAA receptors can initiate this synchronization while inducing a higher conductance state in nonrhythmogenic preBötC output neurons. Our analyses uncover salient features of preBötC network dynamics where inspiratory bursts arise when and only when the preBötC rhythmogenic subpopulation strongly synchronizes to drive output neurons. Furthermore, downstream propagation of preBötC network activity, ultimately to motoneurons, is dependent on the strength of input synchrony onto preBötC output neurons exemplifying synchronous propagation of network activity." @default.
- W3009276911 created "2020-03-13" @default.
- W3009276911 creator A5035524337 @default.
- W3009276911 creator A5064975604 @default.
- W3009276911 date "2020-05-01" @default.
- W3009276911 modified "2023-10-04" @default.
- W3009276911 title "Emergent Elements of Inspiratory Rhythmogenesis: Network Synchronization and Synchrony Propagation" @default.
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- W3009276911 doi "https://doi.org/10.1016/j.neuron.2020.02.005" @default.
- W3009276911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32130872" @default.
- W3009276911 hasPublicationYear "2020" @default.
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