FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009296923> ?p ?o ?g. }

• W3009296923 endingPage "106358" @default.
• W3009296923 startingPage "106358" @default.
• W3009296923 abstract "• We evaluated the PK of an IgG (Gammagard) in very low birth weight neonates. • Our evaluation was based on baseline-corrected and uncorrected IgG serum concentrations. • The two methods of PK evaluation gave different PK parameter estimates. • The PK of Gammagard was substantially different in neonates than adults (historical comparison). • The dose of IgGs should be adjusted based on the PK of baseline corrected profiles. Immunoglobulins are widely used across multiple therapeutic areas such as immunodeficiency syndromes, infection and autoimmune diseases. The pharmacokinetics (PK) of immunoglobulins are well characterized in adults, but very little is known about the PK of immunoglobulins in neonates and infants. The objective of the present study was to characterize the PK of Gammagard, an immunoglobulin, in very low birth weight preterm neonates. Gammagard concentration-time data from very low birth weight neonates (bodyweight range 0.78–1.38 kg, n = 20) following intravenous administration of 500 mg/kg and 750 mg/kg were obtained from the literature. The data were analyzed with and without baseline correction using extensive blood samples (8 blood samples). Model-independent (non-compartmental) analysis was used to characterize the PK of Gammagard. Based on uncorrected baseline concentration-time data, the clearance and half-life of Gammagard were 3.1 ± 0.7 mL/day and 22 ± 6 days, respectively. Based on corrected baseline concentration-time data, the clearance and half-life of Gammagard were 20.2 ± 7.4 mL/day and 5.3 ± 2.2 days, respectively. The dose of immunoglobulins should be adjusted based on the PK of baseline corrected rather than baseline uncorrected profiles because baseline corrected PK parameters especially half-life reconciles with PK principles." @default.
• W3009296923 created "2020-03-13" @default.
• W3009296923 creator A5014032609 @default.
• W3009296923 creator A5037440173 @default.
• W3009296923 creator A5037939650 @default.
• W3009296923 date "2020-05-01" @default.
• W3009296923 modified "2023-10-18" @default.
• W3009296923 title "Considerations for pharmacokinetic assessment of immunoglobulins: Gammagard in very low birth weight neonates with and without baseline-correction" @default.
• W3009296923 cites W1979820418 @default.
• W3009296923 cites W2013305778 @default.
• W3009296923 cites W2016694138 @default.
• W3009296923 cites W2038900628 @default.
• W3009296923 cites W2049760610 @default.
• W3009296923 cites W2050900492 @default.
• W3009296923 cites W2067733905 @default.
• W3009296923 cites W2092375805 @default.
• W3009296923 cites W2141403636 @default.
• W3009296923 cites W2142995477 @default.
• W3009296923 cites W2341400992 @default.
• W3009296923 cites W2502670554 @default.
• W3009296923 doi "https://doi.org/10.1016/j.intimp.2020.106358" @default.
• W3009296923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32135491" @default.
• W3009296923 hasPublicationYear "2020" @default.
• W3009296923 type Work @default.
• W3009296923 sameAs 3009296923 @default.
• W3009296923 citedByCount "1" @default.
• W3009296923 countsByYear W30092969232021 @default.
• W3009296923 crossrefType "journal-article" @default.
• W3009296923 hasAuthorship W3009296923A5014032609 @default.
• W3009296923 hasAuthorship W3009296923A5037440173 @default.
• W3009296923 hasAuthorship W3009296923A5037939650 @default.
• W3009296923 hasConcept C112705442 @default.
• W3009296923 hasConcept C126322002 @default.
• W3009296923 hasConcept C159654299 @default.
• W3009296923 hasConcept C203014093 @default.
• W3009296923 hasConcept C2779234561 @default.
• W3009296923 hasConcept C42407357 @default.
• W3009296923 hasConcept C54355233 @default.
• W3009296923 hasConcept C66322754 @default.
• W3009296923 hasConcept C71924100 @default.
• W3009296923 hasConcept C86803240 @default.
• W3009296923 hasConceptScore W3009296923C112705442 @default.
• W3009296923 hasConceptScore W3009296923C126322002 @default.
• W3009296923 hasConceptScore W3009296923C159654299 @default.
• W3009296923 hasConceptScore W3009296923C203014093 @default.
• W3009296923 hasConceptScore W3009296923C2779234561 @default.
• W3009296923 hasConceptScore W3009296923C42407357 @default.
• W3009296923 hasConceptScore W3009296923C54355233 @default.
• W3009296923 hasConceptScore W3009296923C66322754 @default.
• W3009296923 hasConceptScore W3009296923C71924100 @default.
• W3009296923 hasConceptScore W3009296923C86803240 @default.
• W3009296923 hasLocation W30092969231 @default.
• W3009296923 hasLocation W30092969232 @default.
• W3009296923 hasOpenAccess W3009296923 @default.
• W3009296923 hasPrimaryLocation W30092969231 @default.
• W3009296923 hasRelatedWork W1554392943 @default.
• W3009296923 hasRelatedWork W1934038313 @default.
• W3009296923 hasRelatedWork W1998726531 @default.
• W3009296923 hasRelatedWork W2062826169 @default.
• W3009296923 hasRelatedWork W2070556216 @default.
• W3009296923 hasRelatedWork W2152911432 @default.
• W3009296923 hasRelatedWork W2945124473 @default.
• W3009296923 hasRelatedWork W428203746 @default.
• W3009296923 hasRelatedWork W2184508442 @default.
• W3009296923 hasRelatedWork W2740563594 @default.
• W3009296923 hasVolume "82" @default.
• W3009296923 isParatext "false" @default.
• W3009296923 isRetracted "false" @default.
• W3009296923 magId "3009296923" @default.
• W3009296923 workType "article" @default.