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- W3009341741 abstract "Mechanotransduction is the process by which cells translate a mechanical stimulus, like substrate stiffness, topography, or shear flow, into a biochemical response. Yes-associated protein (YAP) and TAZ are transcriptional coactivators that have been identified as key relay proteins that facilitate mechanotransduction through the Hippo pathway. In healthy tissue in homeostasis, mechanotransduction often limits proliferation, and YAP/TAZ are completely inactive. During tumor progression a YAP/TAZ-activating positive feedback loop is created between the stiffening extracellular matrix and the developing tumor. As cancer progresses, tumor cells and local stromal cells use mechanotransduction to promote proliferation, increase their migratory potential into distant organs, and induce chemotherapeutic resistance. This chapter will discuss the role of mechanotransduction during cancer and how these effects can be studied in vitro. The techniques to quantify cell stiffness and the seminal mechanotransduction platforms used, such as micropillars and four-dimensional hydrogels (three-dimensional culturing platforms with features, such as stiffness, that change with respect to time), will be covered in detail. Lastly, a framework will be presented on how to select the best material for a given mechanotransduction construct." @default.
- W3009341741 created "2020-03-13" @default.
- W3009341741 creator A5049067553 @default.
- W3009341741 creator A5054791772 @default.
- W3009341741 date "2020-01-01" @default.
- W3009341741 modified "2023-09-24" @default.
- W3009341741 title "Cancer mechanobiology: interaction of biomaterials with cancer cells" @default.
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- W3009341741 doi "https://doi.org/10.1016/b978-0-08-102983-1.00016-8" @default.
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