FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009372776> ?p ?o ?g. }

• W3009372776 endingPage "231" @default.
• W3009372776 startingPage "218" @default.
• W3009372776 abstract "Spindle and kinetochore associated complex subunit 1/2/3 (SKA1/2/3), which stabilized spindle microtubules attaching to kinetochore (KT) in the middle stage of mitosis, were dysregulated, and closely related to prognosis in several malignant tumors. Nevertheless, the potential clinical value of SKA1/2/3, especially in terms of prognosis and development of NSCLC, had not been fully elucidated.ONCOMINE, GEPIA, UALCAN, TCGA, STRING and other databases were used to analyze the expression of SKA1/2/3 in patients with lung adenocarcinoma (LUAD) and its clinical value, and to explore the possible regulatory mechanism of SKA in the occurrence and development of LUAD.In patients with LUAD, SKA1/2/3 mRNA expression level was significantly up-regulated, and AUC was 0.9558, 0.7034 and 0.9775, respectively. Increased SKA 1/2/3 expression was associated with smoking, tissue typing, and poor prognosis in LUAD patients. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) showed that SKA1/2/3 was mainly enriched in DNA replication, cell cycle, homologous recombination, p53 signaling pathway, etc. Hub genes in protein-protein interactions are CDK1, BUB1, CCNA2, CDC20, CCNB2, CCNB1, BUB1B, AURKB, TOP2A and MAD2L1. Hub gene expression in LUAD is increased, and its increased expression is related to poor prognosis of LUAD patients. Finally, the expression of SKA1/2/3 and its correlation with clinicopathological features were verified in 30 clinical LUAD samples.SKA1/2/3 may serve as a potential prognostic biomarker and target for LUAD. In addition, SKA 1/2/3 may affect the prognosis of LUAD through DNA replication, cell cycle, homologous recombination and p53 signaling pathway." @default.
• W3009372776 created "2020-03-13" @default.
• W3009372776 creator A5023912850 @default.
• W3009372776 creator A5029196561 @default.
• W3009372776 creator A5064548129 @default.
• W3009372776 creator A5080431093 @default.
• W3009372776 creator A5087310769 @default.
• W3009372776 date "2020-04-01" @default.
• W3009372776 modified "2023-10-14" @default.
• W3009372776 title "SKA1/2/3 serves as a biomarker for poor prognosis in human lung adenocarcinoma" @default.
• W3009372776 cites W2006124751 @default.
• W3009372776 cites W2052835275 @default.
• W3009372776 cites W2069747769 @default.
• W3009372776 cites W2105436095 @default.
• W3009372776 cites W2119254941 @default.
• W3009372776 cites W2296450909 @default.
• W3009372776 cites W2442447928 @default.
• W3009372776 cites W2591743248 @default.
• W3009372776 cites W2602874476 @default.
• W3009372776 cites W2612928848 @default.
• W3009372776 cites W2615408292 @default.
• W3009372776 cites W2736418950 @default.
• W3009372776 cites W2805552648 @default.
• W3009372776 cites W2891433834 @default.
• W3009372776 cites W2899175565 @default.
• W3009372776 cites W2901098315 @default.
• W3009372776 cites W2903244362 @default.
• W3009372776 cites W2903776113 @default.
• W3009372776 cites W2907603936 @default.
• W3009372776 cites W2911669023 @default.
• W3009372776 cites W2916953629 @default.
• W3009372776 cites W2941448760 @default.
• W3009372776 cites W2944970632 @default.
• W3009372776 cites W2952016992 @default.
• W3009372776 cites W2956858815 @default.
• W3009372776 cites W2963975935 @default.
• W3009372776 cites W2971455891 @default.
• W3009372776 cites W2973314738 @default.
• W3009372776 cites W2996162834 @default.
• W3009372776 cites W2274361457 @default.
• W3009372776 doi "https://doi.org/10.21037/tlcr.2020.01.20" @default.
• W3009372776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7225159" @default.
• W3009372776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32420061" @default.
• W3009372776 hasPublicationYear "2020" @default.
• W3009372776 type Work @default.
• W3009372776 sameAs 3009372776 @default.
• W3009372776 citedByCount "24" @default.
• W3009372776 countsByYear W30093727762020 @default.
• W3009372776 countsByYear W30093727762021 @default.
• W3009372776 countsByYear W30093727762022 @default.
• W3009372776 countsByYear W30093727762023 @default.
• W3009372776 crossrefType "journal-article" @default.
• W3009372776 hasAuthorship W3009372776A5023912850 @default.
• W3009372776 hasAuthorship W3009372776A5029196561 @default.
• W3009372776 hasAuthorship W3009372776A5064548129 @default.
• W3009372776 hasAuthorship W3009372776A5080431093 @default.
• W3009372776 hasAuthorship W3009372776A5087310769 @default.
• W3009372776 hasBestOaLocation W30093727761 @default.
• W3009372776 hasConcept C104317684 @default.
• W3009372776 hasConcept C121608353 @default.
• W3009372776 hasConcept C126322002 @default.
• W3009372776 hasConcept C143998085 @default.
• W3009372776 hasConcept C150194340 @default.
• W3009372776 hasConcept C152724338 @default.
• W3009372776 hasConcept C192838845 @default.
• W3009372776 hasConcept C2780391303 @default.
• W3009372776 hasConcept C2781182431 @default.
• W3009372776 hasConcept C2781197716 @default.
• W3009372776 hasConcept C29537977 @default.
• W3009372776 hasConcept C2987395477 @default.
• W3009372776 hasConcept C30481170 @default.
• W3009372776 hasConcept C502942594 @default.
• W3009372776 hasConcept C54355233 @default.
• W3009372776 hasConcept C71924100 @default.
• W3009372776 hasConcept C86803240 @default.
• W3009372776 hasConceptScore W3009372776C104317684 @default.
• W3009372776 hasConceptScore W3009372776C121608353 @default.
• W3009372776 hasConceptScore W3009372776C126322002 @default.
• W3009372776 hasConceptScore W3009372776C143998085 @default.
• W3009372776 hasConceptScore W3009372776C150194340 @default.
• W3009372776 hasConceptScore W3009372776C152724338 @default.
• W3009372776 hasConceptScore W3009372776C192838845 @default.
• W3009372776 hasConceptScore W3009372776C2780391303 @default.
• W3009372776 hasConceptScore W3009372776C2781182431 @default.
• W3009372776 hasConceptScore W3009372776C2781197716 @default.
• W3009372776 hasConceptScore W3009372776C29537977 @default.
• W3009372776 hasConceptScore W3009372776C2987395477 @default.
• W3009372776 hasConceptScore W3009372776C30481170 @default.
• W3009372776 hasConceptScore W3009372776C502942594 @default.
• W3009372776 hasConceptScore W3009372776C54355233 @default.
• W3009372776 hasConceptScore W3009372776C71924100 @default.
• W3009372776 hasConceptScore W3009372776C86803240 @default.
• W3009372776 hasIssue "2" @default.
• W3009372776 hasLocation W30093727761 @default.
• W3009372776 hasLocation W30093727762 @default.
• W3009372776 hasLocation W30093727763 @default.
• W3009372776 hasLocation W30093727764 @default.
• W3009372776 hasOpenAccess W3009372776 @default.

• next