FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009417557> ?p ?o ?g. }

• W3009417557 endingPage "3394" @default.
• W3009417557 startingPage "3385" @default.
• W3009417557 abstract "Background & aims Nutritional impairments are highly frequent in pancreatic cancer even in the early stages and have a significant impact on outcomes. The aim of this prospective study was to investigate immune and nutritional impairments, their interrelations and impacts on outcomes in an unselected cohort of patients scheduled for pancreatoduodenectomy due to suspicion of pancreatic cancer. Methods All consecutive patients scheduled for pancreatoduodenectomy at Vilnius University Hospital Santaros Klinikos between January 2016 and November 2018 were recruited into the study according to the inclusion/exclusion criteria. Patients were randomly allocated into the groups of nutritional intervention with immunonutrition vs. control and stratified into the groups of pancreatic ductal adenocarcinoma (PDAC) vs. other pancreatic tumors. Nutritional evaluation included screening (NRS 2002), anthropometric measurements, bioelectrical impedance analysis and lumbar skeletal muscle index (LSMI). Inflammatory indicators were measured before and after surgery. Surgical outcomes were assessed 30 days postoperatively using Comprehensive Complication Index (CCI). Results Although increased nutritional risk was identified in 22.4% of patients, 41.4% were finally diagnosed with cachexia. While cachexia was predominantly diagnosed in underweight patients, sarcopenia was detected across all BMI categories and 11.7% of obese patients had sarcopenia. Decreased LSMI was identified in 52.5% of patients as compared to decreased phase angle in 39% of patients and decreased fat free mass index in only 3.4% of patients. Regression model indicate a large effect of nutritional indicators on CCI (R2 coefficient 71.1%). In comparison to patients with other pancreatic tumors, patients with PDAC had a characteristic pattern of increased systemic inflammation prior to surgery and decreased inflammation postoperatively (p = 0.02). Conclusions A high rate of nutritional impairments was identified in our cohort of patients with early pancreatic cancer, including abnormal body composition phenotypes. They produced negative effects on postoperative outcomes. The highest diagnostic rates were obtained with LSMI measurement, while the highest value for prognostication was attained with the inclusion of multiple objective nutritional state indicators." @default.
• W3009417557 created "2020-03-13" @default.
• W3009417557 creator A5018321723 @default.
• W3009417557 creator A5055245886 @default.
• W3009417557 creator A5071533354 @default.
• W3009417557 creator A5074936417 @default.
• W3009417557 creator A5082693755 @default.
• W3009417557 date "2020-11-01" @default.
• W3009417557 modified "2023-10-18" @default.
• W3009417557 title "Nutritional and immune impairments and their effects on outcomes in early pancreatic cancer patients undergoing pancreatoduodenectomy" @default.
• W3009417557 cites W1828411566 @default.
• W3009417557 cites W1964905091 @default.
• W3009417557 cites W1989460280 @default.
• W3009417557 cites W1991601270 @default.
• W3009417557 cites W2013439462 @default.
• W3009417557 cites W2016514592 @default.
• W3009417557 cites W2033295037 @default.
• W3009417557 cites W2043737378 @default.
• W3009417557 cites W2049647656 @default.
• W3009417557 cites W2069376956 @default.
• W3009417557 cites W2099246031 @default.
• W3009417557 cites W2104846685 @default.
• W3009417557 cites W2118591242 @default.
• W3009417557 cites W2119490885 @default.
• W3009417557 cites W2124537265 @default.
• W3009417557 cites W2125400863 @default.
• W3009417557 cites W2130451039 @default.
• W3009417557 cites W2138938820 @default.
• W3009417557 cites W2145280166 @default.
• W3009417557 cites W2152438927 @default.
• W3009417557 cites W2170774638 @default.
• W3009417557 cites W2226607074 @default.
• W3009417557 cites W2228596173 @default.
• W3009417557 cites W2335126008 @default.
• W3009417557 cites W2415203781 @default.
• W3009417557 cites W2505149831 @default.
• W3009417557 cites W2513201434 @default.
• W3009417557 cites W2521019952 @default.
• W3009417557 cites W2535326237 @default.
• W3009417557 cites W2592057265 @default.
• W3009417557 cites W2706197370 @default.
• W3009417557 cites W2735888641 @default.
• W3009417557 cites W2745975873 @default.
• W3009417557 cites W2758550417 @default.
• W3009417557 cites W2771907223 @default.
• W3009417557 cites W2774571425 @default.
• W3009417557 cites W2777873151 @default.
• W3009417557 cites W2783976065 @default.
• W3009417557 cites W2887425090 @default.
• W3009417557 cites W2892518805 @default.
• W3009417557 cites W2892626431 @default.
• W3009417557 cites W2898368508 @default.
• W3009417557 cites W2899736836 @default.
• W3009417557 cites W2901644252 @default.
• W3009417557 cites W4211165395 @default.
• W3009417557 doi "https://doi.org/10.1016/j.clnu.2020.02.029" @default.
• W3009417557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32184025" @default.
• W3009417557 hasPublicationYear "2020" @default.
• W3009417557 type Work @default.
• W3009417557 sameAs 3009417557 @default.
• W3009417557 citedByCount "16" @default.
• W3009417557 countsByYear W30094175572021 @default.
• W3009417557 countsByYear W30094175572022 @default.
• W3009417557 countsByYear W30094175572023 @default.
• W3009417557 crossrefType "journal-article" @default.
• W3009417557 hasAuthorship W3009417557A5018321723 @default.
• W3009417557 hasAuthorship W3009417557A5055245886 @default.
• W3009417557 hasAuthorship W3009417557A5071533354 @default.
• W3009417557 hasAuthorship W3009417557A5074936417 @default.
• W3009417557 hasAuthorship W3009417557A5082693755 @default.
• W3009417557 hasConcept C121608353 @default.
• W3009417557 hasConcept C126322002 @default.
• W3009417557 hasConcept C188816634 @default.
• W3009417557 hasConcept C2776214593 @default.
• W3009417557 hasConcept C2777704314 @default.
• W3009417557 hasConcept C2780210213 @default.
• W3009417557 hasConcept C2780221984 @default.
• W3009417557 hasConcept C2780586474 @default.
• W3009417557 hasConcept C2781121325 @default.
• W3009417557 hasConcept C2909874672 @default.
• W3009417557 hasConcept C33872192 @default.
• W3009417557 hasConcept C71924100 @default.
• W3009417557 hasConcept C90924648 @default.
• W3009417557 hasConceptScore W3009417557C121608353 @default.
• W3009417557 hasConceptScore W3009417557C126322002 @default.
• W3009417557 hasConceptScore W3009417557C188816634 @default.
• W3009417557 hasConceptScore W3009417557C2776214593 @default.
• W3009417557 hasConceptScore W3009417557C2777704314 @default.
• W3009417557 hasConceptScore W3009417557C2780210213 @default.
• W3009417557 hasConceptScore W3009417557C2780221984 @default.
• W3009417557 hasConceptScore W3009417557C2780586474 @default.
• W3009417557 hasConceptScore W3009417557C2781121325 @default.
• W3009417557 hasConceptScore W3009417557C2909874672 @default.
• W3009417557 hasConceptScore W3009417557C33872192 @default.
• W3009417557 hasConceptScore W3009417557C71924100 @default.
• W3009417557 hasConceptScore W3009417557C90924648 @default.
• W3009417557 hasIssue "11" @default.
• W3009417557 hasLocation W30094175571 @default.

• next