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• W3009477821 abstract "Rationale: Exposure to air pollution during intrauterine development and through childhood may have lasting effects on respiratory health.Objectives: To investigate lung function at ages 8 and 15 years in relation to air pollution exposures during pregnancy, infancy, and childhood in a UK population–based birth cohort.Methods: Individual exposures to source-specific particulate matter ≤10 μm in aerodynamic diameter (PM10) during each trimester, 0–6 months, 7–12 months (1990–1993), and up to age 15 years (1991–2008) were examined in relation to FEV1% predicted and FVC% predicted at ages 8 (n = 5,276) and 15 (n = 3,446) years using linear regression models adjusted for potential confounders. A profile regression model was used to identify sensitive time periods.Measurements and Main Results: We did not find clear evidence of a sensitive exposure period for PM10 from road traffic. At age 8 years, 1 μg/m3 higher exposure during the first trimester was associated with lower FEV1% predicted (−0.826; 95% confidence interval [CI], −1.357 to −0.296) and FVC% predicted (−0.817; 95% CI, −1.357 to −0.276), but similar associations were seen for exposures for other trimesters, 0–6 months, 7–12 months, and 0–7 years. Associations were stronger among boys, as well as children whose mother had a lower education level or smoked during pregnancy. For PM10 from all sources, the third trimester was associated with lower FVC% predicted (−1.312; 95% CI, −2.100 to −0.525). At age 15 years, no adverse associations with lung function were seen.Conclusions: Exposure to road-traffic PM10 during pregnancy may result in small but significant reductions in lung function at age 8 years." @default.
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• W3009477821 date "2020-07-01" @default.
• W3009477821 modified "2023-10-04" @default.
• W3009477821 title "Prenatal, Early-Life, and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort" @default.
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• W3009477821 doi "https://doi.org/10.1164/rccm.201902-0286oc" @default.
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