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- W3009543304 abstract "Loss of heterozygosity (LOH) at several chromosomal loci is a common feature of the malignant progression of human tumours. These regions are thought to harbour one or more putative tumour suppressive gene(s) which may play a role in tumour development. Allelic losses on the short arm of chromosome 8 (8p) have been reported as frequent events in several cancers, including lung cancer. High frequencies of deletions at 8p21-23 regions have been detected in lung cancer cell lines and in primary tumours. There is a suggestion of a putative suppressor gene in the region of 8p23.3 but there is little published data on LOH in this region. Aim: To determine whether there is any evidence of loss of heterozygosity in the region of chromosome 8p23.3 in lung cancer patients. Method: We used 2 microsatellite markers flanking a putative tumour suppressor gene on a cohort of 108 primary lung cancer tumours compared to normal lung tissue. Results: There were 64/108 (%) tumours informative for D8S1109 and 59/108 informative for D8S1107. Of the informative cases, 40.6% and 25.4% showed LOH at D8SI109 and D8S1107 respectively. There were no corelations with gender, smoking status or pathological T, N or M stage. LOH at D8S1109 and D8S1107 was most common in squamous cell carcinomas (11/25 and 10/26 respectively). At this stage, LOH at these two markers did not correlate with survival by Kaplan Meier analysis of survival curves. Conclusion: We found that LOH at 8p23.3 is a relatively frequent event and is consistent with the notion of a putative tumour suppressor gene in this region. Further mapping and mutation analysis is required to exclude candidate genes." @default.
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- W3009543304 date "2001-12-01" @default.
- W3009543304 modified "2023-09-23" @default.
- W3009543304 title "Allelic losses at chromosome 8p23.3 in nsclc" @default.
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