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- W3009585141 abstract "Hepatitis Delta virus (HDV) requires hepatitis B virus (HBV) to complete its infection cycle and causes a severe hepatitis with limited therapeutic options. To determine the prospect of T cell therapy in HBV/HDV co-infection, we first studied the HDV impact on viral antigen processing and presentation. Utilizing in vitro models of HBV/HDV co-infection, we demonstrated that HDV boosts HBV epitope presentation, both in HBV/HDV co-infected and neighboring mono-HBV infected cells through up-regulation of antigen processing pathway mediated by IFN-beta/lambda. This up-regulation was confirmed in liver biopsies of HBV/HDV patients. We then demonstrated in vitro and in HBV/HDV preclinical mouse model that HDV increases antiviral efficacy of HBV-specific T cell receptors engineered T cells. Thus, by unveiling the effect of HDV on HBV antigen presentation, we provide a framework to better understand HBV/HDV immune pathology, and we advocate the use of engineered HBV-specific T cells for the treatment of HBV/HDV co-infection." @default.
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- W3009585141 date "2020-01-01" @default.
- W3009585141 modified "2023-10-16" @default.
- W3009585141 title "Hepatitis Delta Virus Infection Increases the Efficacy of HBV-Specific T Cell-Based Therapies" @default.
- W3009585141 doi "https://doi.org/10.2139/ssrn.3545998" @default.
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