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- W3009586479 abstract "Mechanical ventilation of preterm neonates is associated with neuroinflammation and an increased risk of adverse neurological outcomes. Human amnion epithelial cells (hAECs) have anti-inflammatory and regenerative properties. We aimed to determine if intravenous administration of hAECs to preterm lambs would reduce neuroinflammation and injury at 2 days of age. Preterm lambs were delivered by cesarean section at 128−130 days’ gestation (term is ~147 days) and either ventilated for 48 h or humanely killed at birth. Lambs received 3 mL surfactant (Curosurf) via endotracheal tube prior to delivery (either with or without 90 × 106 hAECs) and 3 mL intravenous phosphate-buffered saline (with or without 90 × 106 hAECs, consistent with intratracheal treatment) after birth. Ventilation increased microglial activation, total oligodendrocyte cell number, cell proliferation and blood−brain barrier permeability (P < 0.05, PBS + ventilation and hAEC + ventilation vs. control), but did not affect numbers of immature and mature oligodendrocytes. Ventilation reduced astrocyte and neuron survival (P < 0.05, PBS + ventilation and hAEC + ventilation vs. control). hAEC administration did not alter markers of neuroinflammation or injury within the white or gray matter. Mechanical ventilation for 48 h upregulated markers of neuroinflammation and injury in preterm lambs. Administration of hAECs did not affect markers of neuroinflammation or injury." @default.
- W3009586479 created "2020-03-13" @default.
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- W3009586479 date "2020-03-02" @default.
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- W3009586479 title "Brain inflammation and injury at 48 h is not altered by human amnion epithelial cells in ventilated preterm lambs" @default.
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- W3009586479 doi "https://doi.org/10.1038/s41390-020-0815-8" @default.
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