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• W3009656996 abstract "Abstract Aim To identify people in English primary care with equivalent cardiovascular risk to participants in the sodium–glucose co‐transporter‐2 inhibitor (SGLT‐2i) cardiovascular outcome trials (CVOTs). A secondary objective was to report the usage of SGLT‐2is. Methods Cross‐sectional analysis of people registered with participating practices in the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) network on the 31 December 2016. We derived: (1) proportions of the primary care population eligible for inclusion in each SGLT‐2i CVOT (CANVAS, DECLARE, EMPA‐REG and VERTIS); (2) characteristics of the eligible population compared with trial participants (demographics, disease duration and vascular risk); and (3) differences within the eligible population prescribed SGLT‐2is. Results The proportions of people with type 2 diabetes ( N = 84 394) meeting the inclusion criteria for each CVOT were: DECLARE 27% [95% confidence interval (CI) 26.5–27.1]; CANVAS 17% (16.6–17.1); VERTIS 7% (7.1–7.4); and EMPA‐REG 7% (6.5–6.8). Primary care populations fulfilling inclusion criteria were 5–8 years older than trial cohorts, and <10% with inclusion criteria of each trial were prescribed an SGLT‐2i; a greater proportion were men, and of white ethnicity. Conclusions There was variation in proportions of the primary care type 2 diabetes population fulfilling inclusion criteria of SGLT‐2i CVOTs. The more stringent the inclusion criteria, the lower the proportion identified in a primary care setting. Prescription rates for SGLT‐2is were low in this national database, and there were demographic disparities in prescribing." @default.
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• W3009656996 date "2020-03-28" @default.
• W3009656996 modified "2023-10-13" @default.
• W3009656996 title "Sodium–glucose co‐transporter‐2 inhibitor cardiovascular outcome trials and generalizability to English primary care" @default.
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• W3009656996 doi "https://doi.org/10.1111/dme.14290" @default.
• W3009656996 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7497070" @default.
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