Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009731929> ?p ?o ?g. }
- W3009731929 endingPage "535" @default.
- W3009731929 startingPage "526" @default.
- W3009731929 abstract "Abstract Novel agonists of the nuclear liver-X-receptor (LXR) are designed to treat metabolic disorders or cancer. The rationale to develop these new drugs is based on promising results with established LXR agonist like T0901317 and GW3965. LXRα and LXRβ are expressed in β-cells, and expression is increased by T0901317. The aim of the present study was to evaluate whether effects of these drugs on β-cell function are specific and reliably linked to LXR activation. T0901317 and GW3965, widely used as specific LXR agonists, show rapid, non-genomic effects on stimulus-secretion coupling of mouse pancreatic β-cells at low µM concentrations. T0901317 lowered the cytosolic Ca 2+ concentration, reduced or completely inhibited action potentials, and decreased insulin secretion. GW3965 exerted similar effects on insulin secretion. T0901317 affected the production of reactive oxygen species and ATP. The involvement of the classical nuclear LXRs in T0901317- and GW3965-mediated effects in β-cells could be ruled out using LXRα, LXRβ and double knockout mice. Our results strongly suggest that LXR agonists, that are considered to be specific for this receptor, interfere with mitochondrial metabolism and metabolism-independent processes in β-cells. Thus, it is indispensable to test novel LXR agonists accompanying to ongoing clinical trials for acute and chronic effects on cell function in cellular systems and/or animal models lacking classical LXRs." @default.
- W3009731929 created "2020-03-13" @default.
- W3009731929 creator A5007818122 @default.
- W3009731929 creator A5032918352 @default.
- W3009731929 creator A5038941899 @default.
- W3009731929 creator A5065909022 @default.
- W3009731929 date "2020-03-07" @default.
- W3009731929 modified "2023-10-06" @default.
- W3009731929 title "Approved LXR agonists exert unspecific effects on pancreatic β-cell function" @default.
- W3009731929 cites W1963933860 @default.
- W3009731929 cites W1971085062 @default.
- W3009731929 cites W1974521128 @default.
- W3009731929 cites W1974555331 @default.
- W3009731929 cites W1979260948 @default.
- W3009731929 cites W1981467972 @default.
- W3009731929 cites W1985123019 @default.
- W3009731929 cites W1985296107 @default.
- W3009731929 cites W1987966715 @default.
- W3009731929 cites W1996168740 @default.
- W3009731929 cites W2004400536 @default.
- W3009731929 cites W2014802511 @default.
- W3009731929 cites W2022915573 @default.
- W3009731929 cites W2039664177 @default.
- W3009731929 cites W2039871261 @default.
- W3009731929 cites W2040417680 @default.
- W3009731929 cites W2047120026 @default.
- W3009731929 cites W2052952692 @default.
- W3009731929 cites W2056279264 @default.
- W3009731929 cites W2061725840 @default.
- W3009731929 cites W2077411765 @default.
- W3009731929 cites W2079057288 @default.
- W3009731929 cites W2081893625 @default.
- W3009731929 cites W2090482031 @default.
- W3009731929 cites W2103554380 @default.
- W3009731929 cites W2105866876 @default.
- W3009731929 cites W2106617595 @default.
- W3009731929 cites W2111917147 @default.
- W3009731929 cites W2116613046 @default.
- W3009731929 cites W2129551080 @default.
- W3009731929 cites W2130092916 @default.
- W3009731929 cites W2132261361 @default.
- W3009731929 cites W2149457192 @default.
- W3009731929 cites W2159425655 @default.
- W3009731929 cites W2497098123 @default.
- W3009731929 cites W2530383509 @default.
- W3009731929 cites W2609625866 @default.
- W3009731929 cites W2625924666 @default.
- W3009731929 cites W2783471328 @default.
- W3009731929 doi "https://doi.org/10.1007/s12020-020-02241-4" @default.
- W3009731929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7308254" @default.
- W3009731929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32146655" @default.
- W3009731929 hasPublicationYear "2020" @default.
- W3009731929 type Work @default.
- W3009731929 sameAs 3009731929 @default.
- W3009731929 citedByCount "4" @default.
- W3009731929 countsByYear W30097319292021 @default.
- W3009731929 countsByYear W30097319292022 @default.
- W3009731929 countsByYear W30097319292023 @default.
- W3009731929 crossrefType "journal-article" @default.
- W3009731929 hasAuthorship W3009731929A5007818122 @default.
- W3009731929 hasAuthorship W3009731929A5032918352 @default.
- W3009731929 hasAuthorship W3009731929A5038941899 @default.
- W3009731929 hasAuthorship W3009731929A5065909022 @default.
- W3009731929 hasBestOaLocation W30097319291 @default.
- W3009731929 hasConcept C104317684 @default.
- W3009731929 hasConcept C126322002 @default.
- W3009731929 hasConcept C134018914 @default.
- W3009731929 hasConcept C167400880 @default.
- W3009731929 hasConcept C170493617 @default.
- W3009731929 hasConcept C185592680 @default.
- W3009731929 hasConcept C2778938600 @default.
- W3009731929 hasConcept C55493867 @default.
- W3009731929 hasConcept C63932345 @default.
- W3009731929 hasConcept C71924100 @default.
- W3009731929 hasConcept C86339819 @default.
- W3009731929 hasConcept C86803240 @default.
- W3009731929 hasConceptScore W3009731929C104317684 @default.
- W3009731929 hasConceptScore W3009731929C126322002 @default.
- W3009731929 hasConceptScore W3009731929C134018914 @default.
- W3009731929 hasConceptScore W3009731929C167400880 @default.
- W3009731929 hasConceptScore W3009731929C170493617 @default.
- W3009731929 hasConceptScore W3009731929C185592680 @default.
- W3009731929 hasConceptScore W3009731929C2778938600 @default.
- W3009731929 hasConceptScore W3009731929C55493867 @default.
- W3009731929 hasConceptScore W3009731929C63932345 @default.
- W3009731929 hasConceptScore W3009731929C71924100 @default.
- W3009731929 hasConceptScore W3009731929C86339819 @default.
- W3009731929 hasConceptScore W3009731929C86803240 @default.
- W3009731929 hasIssue "3" @default.
- W3009731929 hasLocation W30097319291 @default.
- W3009731929 hasLocation W30097319292 @default.
- W3009731929 hasLocation W30097319293 @default.
- W3009731929 hasOpenAccess W3009731929 @default.
- W3009731929 hasPrimaryLocation W30097319291 @default.
- W3009731929 hasRelatedWork W2018368842 @default.
- W3009731929 hasRelatedWork W2027913950 @default.
- W3009731929 hasRelatedWork W2033472167 @default.
- W3009731929 hasRelatedWork W2034583712 @default.