Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009739462> ?p ?o ?g. }
- W3009739462 endingPage "1948" @default.
- W3009739462 startingPage "1935" @default.
- W3009739462 abstract "Hepatitis B virus (HBV) infection is ranked among the top health priorities worldwide. Accumulating evidence suggests that HBV infection and replication are closely associated with liver metabolism. The liver X receptors (LXRs), which belong to the superfamily of nuclear hormone receptors, are important physiological regulators of lipid and cholesterol metabolism. However, the association between the LXR pathway and HBV infection remains largely unclear.In this study, the antiviral activity of LXR agonists was investigated using multiple HBV cellular models. We observed that in HBV-infected primary human hepatocytes (PHHs), synthetic LXR agonists (T0901317, GW3965, and LXR-623), but not an LXR antagonist (SR9238), potently inhibited HBV replication and gene expression, as demonstrated by substantial reductions in viral RNA, DNA, and antigen production following agonist treatment. However, covalently closed circular DNA (cccDNA) levels were not significantly reduced by the agonists. In addition, no rebound in viral replication was observed after treatment withdrawal, indicating a long-lasting inhibitory effect. These results suggest that LXR agonists decrease the transcriptional activity of cccDNA. In contrast, no significant anti-HBV effect was observed in HepG2-derived cell lines. Interestingly, LXR agonist treatment strongly reduced cholesterol 7α-hydroxylase 1 (CYP7A1) mRNA levels. Knockdown of CYP7A1 gene expression with small interfering RNA inhibited HBV activity in PHHs, suggesting CYP7A1 as a potential factor contributing to the antiviral effects of LXR agonists.We found that activation of the LXR pathway with synthetic LXR agonists could elicit potent anti-HBV activity in PHHs, possibly through sustained suppression of cccDNA transcription. Our work highlights the therapeutic potential of targeting the LXR pathway for the treatment of chronic HBV infection." @default.
- W3009739462 created "2020-03-13" @default.
- W3009739462 creator A5010458663 @default.
- W3009739462 creator A5062492688 @default.
- W3009739462 creator A5065101788 @default.
- W3009739462 creator A5072970065 @default.
- W3009739462 creator A5079209447 @default.
- W3009739462 creator A5089937629 @default.
- W3009739462 date "2020-12-01" @default.
- W3009739462 modified "2023-10-01" @default.
- W3009739462 title "Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes" @default.
- W3009739462 cites W1576970184 @default.
- W3009739462 cites W1579006740 @default.
- W3009739462 cites W1822042631 @default.
- W3009739462 cites W1918954877 @default.
- W3009739462 cites W1963933860 @default.
- W3009739462 cites W1966393716 @default.
- W3009739462 cites W1991670540 @default.
- W3009739462 cites W1996168740 @default.
- W3009739462 cites W1997460350 @default.
- W3009739462 cites W2002248228 @default.
- W3009739462 cites W2005911243 @default.
- W3009739462 cites W2007697984 @default.
- W3009739462 cites W2008437845 @default.
- W3009739462 cites W2013759529 @default.
- W3009739462 cites W2014864566 @default.
- W3009739462 cites W2025269775 @default.
- W3009739462 cites W2026587556 @default.
- W3009739462 cites W2031579836 @default.
- W3009739462 cites W2040417680 @default.
- W3009739462 cites W2046658442 @default.
- W3009739462 cites W2064200824 @default.
- W3009739462 cites W2120426460 @default.
- W3009739462 cites W2139860640 @default.
- W3009739462 cites W2150047093 @default.
- W3009739462 cites W2153673003 @default.
- W3009739462 cites W2159332620 @default.
- W3009739462 cites W2252267431 @default.
- W3009739462 cites W2340954406 @default.
- W3009739462 cites W2418554548 @default.
- W3009739462 cites W2497098123 @default.
- W3009739462 cites W2792238529 @default.
- W3009739462 cites W2808548053 @default.
- W3009739462 cites W2890638701 @default.
- W3009739462 cites W2899751126 @default.
- W3009739462 cites W2937484488 @default.
- W3009739462 cites W2952107284 @default.
- W3009739462 cites W2952123416 @default.
- W3009739462 doi "https://doi.org/10.1002/hep.31217" @default.
- W3009739462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32145089" @default.
- W3009739462 hasPublicationYear "2020" @default.
- W3009739462 type Work @default.
- W3009739462 sameAs 3009739462 @default.
- W3009739462 citedByCount "11" @default.
- W3009739462 countsByYear W30097394622020 @default.
- W3009739462 countsByYear W30097394622021 @default.
- W3009739462 countsByYear W30097394622022 @default.
- W3009739462 countsByYear W30097394622023 @default.
- W3009739462 crossrefType "journal-article" @default.
- W3009739462 hasAuthorship W3009739462A5010458663 @default.
- W3009739462 hasAuthorship W3009739462A5062492688 @default.
- W3009739462 hasAuthorship W3009739462A5065101788 @default.
- W3009739462 hasAuthorship W3009739462A5072970065 @default.
- W3009739462 hasAuthorship W3009739462A5079209447 @default.
- W3009739462 hasAuthorship W3009739462A5089937629 @default.
- W3009739462 hasConcept C104317684 @default.
- W3009739462 hasConcept C134018914 @default.
- W3009739462 hasConcept C140704245 @default.
- W3009739462 hasConcept C159047783 @default.
- W3009739462 hasConcept C167400880 @default.
- W3009739462 hasConcept C170493617 @default.
- W3009739462 hasConcept C173396325 @default.
- W3009739462 hasConcept C189490182 @default.
- W3009739462 hasConcept C2522874641 @default.
- W3009739462 hasConcept C2777410769 @default.
- W3009739462 hasConcept C2778163477 @default.
- W3009739462 hasConcept C2778938600 @default.
- W3009739462 hasConcept C2780593183 @default.
- W3009739462 hasConcept C55493867 @default.
- W3009739462 hasConcept C63932345 @default.
- W3009739462 hasConcept C86339819 @default.
- W3009739462 hasConcept C86803240 @default.
- W3009739462 hasConcept C89673097 @default.
- W3009739462 hasConceptScore W3009739462C104317684 @default.
- W3009739462 hasConceptScore W3009739462C134018914 @default.
- W3009739462 hasConceptScore W3009739462C140704245 @default.
- W3009739462 hasConceptScore W3009739462C159047783 @default.
- W3009739462 hasConceptScore W3009739462C167400880 @default.
- W3009739462 hasConceptScore W3009739462C170493617 @default.
- W3009739462 hasConceptScore W3009739462C173396325 @default.
- W3009739462 hasConceptScore W3009739462C189490182 @default.
- W3009739462 hasConceptScore W3009739462C2522874641 @default.
- W3009739462 hasConceptScore W3009739462C2777410769 @default.
- W3009739462 hasConceptScore W3009739462C2778163477 @default.
- W3009739462 hasConceptScore W3009739462C2778938600 @default.
- W3009739462 hasConceptScore W3009739462C2780593183 @default.
- W3009739462 hasConceptScore W3009739462C55493867 @default.
- W3009739462 hasConceptScore W3009739462C63932345 @default.