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- W3009761929 abstract "Abstract Background Actinic cheilitis is induced by chronic exposure to ultraviolet radiation and shows solar elastosis, a feature that has been associated with mast cell infiltrates. This study aimed to investigate the area of solar elastosis, collagen loss, and mast cell infiltrates in a series of actinic cheilitis. Methods We evaluated the epithelial dysplasia in 52 cases of actinic cheilitis and the solar elastosis with Weigert's resorcin‐fuchsin. Collagen loss was evaluated with Picrosirius red, analyzed under polarized microscopy, and scored from 1 to 3. Elastosis proportionate area (EPA) was calculated with image software. Mast cells were highlighted with toluidine blue stain. Results EPA varied from 2% to 45%, with a mean of 17.1% in the cases, with no differences among epithelial dysplasia degrees. Most cases presented collagen loss scores of 2 or 3, and higher loss of type I collagen was associated with older age. Mast cell density was higher in severe epithelial dysplasia ( P = 0.002) and in high‐risk cases ( P = 0.01). Conclusion Actinic cheilitis presented variable EPA and marked loss of type I collagen; however, these features were not associated with the degrees of epithelial dysplasia. Besides, mast cell density increased with epithelial dysplasia worsening and this was not associated with elastosis area or collagen loss." @default.
- W3009761929 created "2020-03-13" @default.
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- W3009761929 date "2020-03-20" @default.
- W3009761929 modified "2023-10-16" @default.
- W3009761929 title "Histopathological features of photodamage and mast cell infiltrate in actinic cheilitis with different grades of epithelial dysplasia" @default.
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- W3009761929 doi "https://doi.org/10.1111/cup.13677" @default.
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