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- W3009763409 abstract "Abstract The respiratory pathway of mitochondria is composed of four electron transfer complexes and the ATP synthase. In this article, we review evidence from studies of Saccharomyces cerevisiae that both ATP synthase and cytochrome oxidase (COX) are assembled from independent modules that correspond to structurally and functionally identifiable components of each complex. Biogenesis of the respiratory chain requires a coordinate and balanced expression of gene products that become partner subunits of the same complex, but are encoded in the two physically separated genomes. Current evidence indicates that synthesis of two key mitochondrial encoded subunits of ATP synthase is regulated by the F 1 module. Expression of COX1 that codes for a subunit of the COX catalytic core is also regulated by a mechanism that restricts synthesis of this subunit to the availability of a nuclear-encoded translational activator. The respiratory chain must maintain a fixed stoichiometry of the component enzyme complexes during cell growth. We propose that high-molecular-weight complexes composed of Cox6, a subunit of COX, and of the Atp9 subunit of ATP synthase play a key role in establishing the ratio of the two complexes during their assembly." @default.
- W3009763409 created "2020-03-13" @default.
- W3009763409 creator A5042695366 @default.
- W3009763409 creator A5063342294 @default.
- W3009763409 creator A5067604299 @default.
- W3009763409 date "2020-05-26" @default.
- W3009763409 modified "2023-09-25" @default.
- W3009763409 title "Modular assembly of yeast mitochondrial ATP synthase and cytochrome oxidase" @default.
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