FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009772693> ?p ?o ?g. }

• W3009772693 abstract "Abstract Protein oligomerization is a fundamental process to build complex functional modules. Domains that facilitate the oligomerization process are diverse and widespread in nature across all kingdoms of life. One such domain is the Phox and Bem1 (PB1) domain, which is functionally well-studied in the animal kingdom. However, beyond animals, neither the origin nor the evolutionary patterns of PB1-containing proteins are understood. While PB1 domain proteins have been found in other kingdoms including plants, it is unclear how these relate to animal PB1 proteins. To address this question, we utilized large transcriptome datasets along with the proteomes of a broad range of species. We discovered eight PB1 domain-containing protein families in plants, along with four each in Protozoa and Fungi and three families in Chromista. Studying the deep evolutionary history of PB1 domains throughout eukaryotes revealed the presence of at least two, but likely three, ancestral PB1 copies in the Last Eukaryotic Common Ancestor (LECA). These three ancestral copies gave rise to multiple orthologues later in evolution. Analyzing the sequence and secondary structure properties of plant PB1 domains from all the eight families showed their common ubiquitin β-grasp fold, despite poor sequence identity. Tertiary structural models of these plant PB1 families, combined with Random Forest based classification, indicated family-specific differences attributed to the length of PB1 domain and the proportion of β-sheets. Thus, this study not only identifies novel PB1 families, but also provides an evolutionary basis to understand their diverse functional interactions." @default.
• W3009772693 created "2020-03-13" @default.
• W3009772693 creator A5046552849 @default.
• W3009772693 creator A5080573966 @default.
• W3009772693 date "2020-03-02" @default.
• W3009772693 modified "2023-10-17" @default.
• W3009772693 title "Deep Evolutionary History of the Phox and Bem1 (PB1) Domain Across Eukaryotes" @default.
• W3009772693 cites W1560056935 @default.
• W3009772693 cites W1589807584 @default.
• W3009772693 cites W1591325634 @default.
• W3009772693 cites W1803102843 @default.
• W3009772693 cites W1969034370 @default.
• W3009772693 cites W1974578806 @default.
• W3009772693 cites W1985517000 @default.
• W3009772693 cites W1989228071 @default.
• W3009772693 cites W1997732742 @default.
• W3009772693 cites W2004766011 @default.
• W3009772693 cites W2009849037 @default.
• W3009772693 cites W2018636808 @default.
• W3009772693 cites W2019619926 @default.
• W3009772693 cites W2021039359 @default.
• W3009772693 cites W2026938943 @default.
• W3009772693 cites W2027235566 @default.
• W3009772693 cites W2029030025 @default.
• W3009772693 cites W2042139142 @default.
• W3009772693 cites W2063015800 @default.
• W3009772693 cites W2063965648 @default.
• W3009772693 cites W2067653283 @default.
• W3009772693 cites W2072084253 @default.
• W3009772693 cites W2073302338 @default.
• W3009772693 cites W2074161304 @default.
• W3009772693 cites W2085449098 @default.
• W3009772693 cites W2098320231 @default.
• W3009772693 cites W2101291993 @default.
• W3009772693 cites W2102619095 @default.
• W3009772693 cites W2106798993 @default.
• W3009772693 cites W2111647009 @default.
• W3009772693 cites W2115567294 @default.
• W3009772693 cites W2115888213 @default.
• W3009772693 cites W2127081269 @default.
• W3009772693 cites W2136102488 @default.
• W3009772693 cites W2142678478 @default.
• W3009772693 cites W2145149844 @default.
• W3009772693 cites W2160378127 @default.
• W3009772693 cites W2160690435 @default.
• W3009772693 cites W2163940928 @default.
• W3009772693 cites W2171464043 @default.
• W3009772693 cites W2279275813 @default.
• W3009772693 cites W2571958161 @default.
• W3009772693 cites W2588923851 @default.
• W3009772693 cites W2614081736 @default.
• W3009772693 cites W2750791471 @default.
• W3009772693 cites W2765380711 @default.
• W3009772693 cites W2769924866 @default.
• W3009772693 cites W2789857505 @default.
• W3009772693 cites W2911964244 @default.
• W3009772693 cites W2936079256 @default.
• W3009772693 cites W2948774101 @default.
• W3009772693 cites W2982160768 @default.
• W3009772693 cites W3003235170 @default.
• W3009772693 doi "https://doi.org/10.1038/s41598-020-60733-9" @default.
• W3009772693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7051960" @default.
• W3009772693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32123237" @default.
• W3009772693 hasPublicationYear "2020" @default.
• W3009772693 type Work @default.
• W3009772693 sameAs 3009772693 @default.
• W3009772693 citedByCount "13" @default.
• W3009772693 countsByYear W30097726932020 @default.
• W3009772693 countsByYear W30097726932021 @default.
• W3009772693 countsByYear W30097726932022 @default.
• W3009772693 crossrefType "journal-article" @default.
• W3009772693 hasAuthorship W3009772693A5046552849 @default.
• W3009772693 hasAuthorship W3009772693A5080573966 @default.
• W3009772693 hasBestOaLocation W30097726931 @default.
• W3009772693 hasConcept C104317684 @default.
• W3009772693 hasConcept C104397665 @default.
• W3009772693 hasConcept C134306372 @default.
• W3009772693 hasConcept C14036430 @default.
• W3009772693 hasConcept C144292202 @default.
• W3009772693 hasConcept C171897839 @default.
• W3009772693 hasConcept C197583594 @default.
• W3009772693 hasConcept C33923547 @default.
• W3009772693 hasConcept C36503486 @default.
• W3009772693 hasConcept C54355233 @default.
• W3009772693 hasConcept C62142553 @default.
• W3009772693 hasConcept C70721500 @default.
• W3009772693 hasConcept C78458016 @default.
• W3009772693 hasConcept C86803240 @default.
• W3009772693 hasConcept C90132467 @default.
• W3009772693 hasConceptScore W3009772693C104317684 @default.
• W3009772693 hasConceptScore W3009772693C104397665 @default.
• W3009772693 hasConceptScore W3009772693C134306372 @default.
• W3009772693 hasConceptScore W3009772693C14036430 @default.
• W3009772693 hasConceptScore W3009772693C144292202 @default.
• W3009772693 hasConceptScore W3009772693C171897839 @default.
• W3009772693 hasConceptScore W3009772693C197583594 @default.
• W3009772693 hasConceptScore W3009772693C33923547 @default.
• W3009772693 hasConceptScore W3009772693C36503486 @default.
• W3009772693 hasConceptScore W3009772693C54355233 @default.
• W3009772693 hasConceptScore W3009772693C62142553 @default.

• next