FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009794328> ?p ?o ?g. }

• W3009794328 endingPage "1688" @default.
• W3009794328 startingPage "1678" @default.
• W3009794328 abstract "Maternally expressed gene 3 (MEG3) is a long non-coding RNA (lncRNA) and involved in progression of various human tumors. However, its underlying regulatory mechanism in tumorigenesis of bladder cancer (BC) remains unclear. To demonstrate effects of MEG3 on BC cell proliferation and elaborate its regulatory mechanism in BC.Aberrant expressions of MEG3 and miR-93-5p were induced by cell transfection. The mRNA and protein expression were analyzed using qRT-PCR and western blot. Cell proliferation was examined by CCK-8 assay and EdU staining. The targeted regulation effect of MEG3 on miR-93-5p was confirmed by luciferase reporter assay. The number of LC3 punctated cells was detected by immunofluorescence. Xeno-graft mouse model was constructed for in vivo validation.MEG3 was down-regulated with increased expression of miR-93-5p in BC cells and tissues. Luciferase reporter assay showed that miR-93-5p was a direct target of MEG3 and was negatively regulated by MEG3. MEG3 overexpression inhibited cell proliferation and the expression of proliferation-, apoptosis- and autophagy-related proteins. The activation of PI3K/AKT/mTOR pathway was also suppressed with elevated cell apoptosis. miR-93-5p overexpression counteracted these results. In vivo experiments, we confirmed that miR-93-5p overexpression reversed the MEG3 overexpression-mediated suppression on tumor growth and protein expression.lncRNA MEG3 could function as a competing endogenous RNA of miR-93 to regulate the tumorigenesis of BC via PI3K/AKT/mTOR pathway. The present research provided a new perspective to understanding the pathogenic mechanism of BC, and an effective therapeutic target for BC." @default.
• W3009794328 created "2020-03-13" @default.
• W3009794328 creator A5025087382 @default.
• W3009794328 creator A5027897052 @default.
• W3009794328 creator A5055477684 @default.
• W3009794328 creator A5073165924 @default.
• W3009794328 date "2020-03-01" @default.
• W3009794328 modified "2023-09-25" @default.
• W3009794328 title "Long non-coding RNA MEG3 functions as a competing endogenous RNA of miR-93 to regulate bladder cancer progression via PI3K/AKT/mTOR pathway" @default.
• W3009794328 cites W1546547645 @default.
• W3009794328 cites W2050114212 @default.
• W3009794328 cites W2126598648 @default.
• W3009794328 cites W2130687298 @default.
• W3009794328 cites W2147535627 @default.
• W3009794328 cites W2151721435 @default.
• W3009794328 cites W2167865100 @default.
• W3009794328 cites W2174896178 @default.
• W3009794328 cites W2473455681 @default.
• W3009794328 cites W2536022581 @default.
• W3009794328 cites W2552206015 @default.
• W3009794328 cites W2592488370 @default.
• W3009794328 cites W2596527793 @default.
• W3009794328 cites W2605001769 @default.
• W3009794328 cites W2741267727 @default.
• W3009794328 cites W2743174521 @default.
• W3009794328 cites W2768096340 @default.
• W3009794328 cites W2794672878 @default.
• W3009794328 cites W2808731276 @default.
• W3009794328 cites W2911472947 @default.
• W3009794328 cites W2957558646 @default.
• W3009794328 cites W2962697121 @default.
• W3009794328 cites W2962996429 @default.
• W3009794328 cites W4211115520 @default.
• W3009794328 doi "https://doi.org/10.21037/tcr.2020.01.70" @default.
• W3009794328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35117516" @default.
• W3009794328 hasPublicationYear "2020" @default.
• W3009794328 type Work @default.
• W3009794328 sameAs 3009794328 @default.
• W3009794328 citedByCount "9" @default.
• W3009794328 countsByYear W30097943282020 @default.
• W3009794328 countsByYear W30097943282021 @default.
• W3009794328 countsByYear W30097943282022 @default.
• W3009794328 countsByYear W30097943282023 @default.
• W3009794328 crossrefType "journal-article" @default.
• W3009794328 hasAuthorship W3009794328A5025087382 @default.
• W3009794328 hasAuthorship W3009794328A5027897052 @default.
• W3009794328 hasAuthorship W3009794328A5055477684 @default.
• W3009794328 hasAuthorship W3009794328A5073165924 @default.
• W3009794328 hasBestOaLocation W30097943281 @default.
• W3009794328 hasConcept C104317684 @default.
• W3009794328 hasConcept C150194340 @default.
• W3009794328 hasConcept C153911025 @default.
• W3009794328 hasConcept C161733203 @default.
• W3009794328 hasConcept C185592680 @default.
• W3009794328 hasConcept C2781369401 @default.
• W3009794328 hasConcept C502942594 @default.
• W3009794328 hasConcept C55493867 @default.
• W3009794328 hasConcept C555283112 @default.
• W3009794328 hasConcept C60365752 @default.
• W3009794328 hasConcept C62112901 @default.
• W3009794328 hasConcept C62203573 @default.
• W3009794328 hasConcept C62478195 @default.
• W3009794328 hasConcept C67705224 @default.
• W3009794328 hasConcept C75217442 @default.
• W3009794328 hasConcept C86554907 @default.
• W3009794328 hasConcept C86803240 @default.
• W3009794328 hasConcept C95444343 @default.
• W3009794328 hasConceptScore W3009794328C104317684 @default.
• W3009794328 hasConceptScore W3009794328C150194340 @default.
• W3009794328 hasConceptScore W3009794328C153911025 @default.
• W3009794328 hasConceptScore W3009794328C161733203 @default.
• W3009794328 hasConceptScore W3009794328C185592680 @default.
• W3009794328 hasConceptScore W3009794328C2781369401 @default.
• W3009794328 hasConceptScore W3009794328C502942594 @default.
• W3009794328 hasConceptScore W3009794328C55493867 @default.
• W3009794328 hasConceptScore W3009794328C555283112 @default.
• W3009794328 hasConceptScore W3009794328C60365752 @default.
• W3009794328 hasConceptScore W3009794328C62112901 @default.
• W3009794328 hasConceptScore W3009794328C62203573 @default.
• W3009794328 hasConceptScore W3009794328C62478195 @default.
• W3009794328 hasConceptScore W3009794328C67705224 @default.
• W3009794328 hasConceptScore W3009794328C75217442 @default.
• W3009794328 hasConceptScore W3009794328C86554907 @default.
• W3009794328 hasConceptScore W3009794328C86803240 @default.
• W3009794328 hasConceptScore W3009794328C95444343 @default.
• W3009794328 hasIssue "3" @default.
• W3009794328 hasLocation W30097943281 @default.
• W3009794328 hasLocation W30097943282 @default.
• W3009794328 hasLocation W30097943283 @default.
• W3009794328 hasOpenAccess W3009794328 @default.
• W3009794328 hasPrimaryLocation W30097943281 @default.
• W3009794328 hasRelatedWork W1988747615 @default.
• W3009794328 hasRelatedWork W2044529491 @default.
• W3009794328 hasRelatedWork W2438578109 @default.
• W3009794328 hasRelatedWork W2569065262 @default.
• W3009794328 hasRelatedWork W2618376745 @default.
• W3009794328 hasRelatedWork W2767148998 @default.
• W3009794328 hasRelatedWork W2898320982 @default.

• next