Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009803277> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W3009803277 endingPage "272" @default.
- W3009803277 startingPage "266" @default.
- W3009803277 abstract "Concerns about the side effects and interactions of biologic drugs with reproduction and pregnancy have been always an issue between experts. The safety of these therapies during conception and/or pregnancy is not fully understood. The aim of this study was to assess the exposure to biologic drugs before and/or during conception/pregnancy and the risk of adverse pregnancy outcomes in women with rheumatic diseases.We conducted a cohort study of pregnancies reported in women with immune-mediated rheumatic diseases registered at the Rheumatic Diseases Portuguese Registry (Reuma.pt) and exposed to biologic drugs. Data concerning fetal and maternal outcomes (live birth, spontaneous abortion, neonatal and intrauterine death, intrauterine growth restriction, premature delivery, congenital malformations, neonatal lupus, voluntary or medical interruption of pregnancy, disease flares and need for treatment with other drugs) was extracted.In total, 69 pregnancies from 56 females were analysed, the majority with the diagnosis of spondyloarthritis or rheumatoid arthritis. In almost half of the cases (n=32, 46.4%) the biologic was stopped for pregnancy planning, in 31 cases (44.9%) it was stopped when pregnancy was diagnosed and in 6 pregnancies (8.7%) biologic therapy was maintained, at least until the 2nd trimester. There were 76.8% of live births and 22% of spontaneous abortions. Congenital anomalies were reported in 2 newborns.In half cases, it was decided to stop biologic therapy in the family planning period. Using biologic disease-modifying anti-rheumatic drugs before and/or during pregnancy doesn't seem to affect the overall maternal and fetal outcomes. Pregnancy planning and treatment options should be discussed and a shared decision should be established between physician and patient." @default.
- W3009803277 created "2020-03-13" @default.
- W3009803277 creator A5005974898 @default.
- W3009803277 creator A5012961547 @default.
- W3009803277 creator A5014561267 @default.
- W3009803277 creator A5026473621 @default.
- W3009803277 creator A5044555520 @default.
- W3009803277 creator A5044724637 @default.
- W3009803277 creator A5052321048 @default.
- W3009803277 creator A5057857463 @default.
- W3009803277 creator A5059601670 @default.
- W3009803277 creator A5067489538 @default.
- W3009803277 creator A5074772621 @default.
- W3009803277 creator A5075879751 @default.
- W3009803277 creator A5078386943 @default.
- W3009803277 creator A5079625443 @default.
- W3009803277 date "2020-02-03" @default.
- W3009803277 modified "2023-09-27" @default.
- W3009803277 title "Biologic therapy use and pregnancy outcomes in women with immune-mediated inflammatory rheumatic diseases." @default.
- W3009803277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32008032" @default.
- W3009803277 hasPublicationYear "2020" @default.
- W3009803277 type Work @default.
- W3009803277 sameAs 3009803277 @default.
- W3009803277 citedByCount "1" @default.
- W3009803277 countsByYear W30098032772021 @default.
- W3009803277 crossrefType "journal-article" @default.
- W3009803277 hasAuthorship W3009803277A5005974898 @default.
- W3009803277 hasAuthorship W3009803277A5012961547 @default.
- W3009803277 hasAuthorship W3009803277A5014561267 @default.
- W3009803277 hasAuthorship W3009803277A5026473621 @default.
- W3009803277 hasAuthorship W3009803277A5044555520 @default.
- W3009803277 hasAuthorship W3009803277A5044724637 @default.
- W3009803277 hasAuthorship W3009803277A5052321048 @default.
- W3009803277 hasAuthorship W3009803277A5057857463 @default.
- W3009803277 hasAuthorship W3009803277A5059601670 @default.
- W3009803277 hasAuthorship W3009803277A5067489538 @default.
- W3009803277 hasAuthorship W3009803277A5074772621 @default.
- W3009803277 hasAuthorship W3009803277A5075879751 @default.
- W3009803277 hasAuthorship W3009803277A5078386943 @default.
- W3009803277 hasAuthorship W3009803277A5079625443 @default.
- W3009803277 hasConcept C126322002 @default.
- W3009803277 hasConcept C131872663 @default.
- W3009803277 hasConcept C172680121 @default.
- W3009803277 hasConcept C187212893 @default.
- W3009803277 hasConcept C203014093 @default.
- W3009803277 hasConcept C2777575956 @default.
- W3009803277 hasConcept C2778279030 @default.
- W3009803277 hasConcept C2778642596 @default.
- W3009803277 hasConcept C2778780700 @default.
- W3009803277 hasConcept C2779134260 @default.
- W3009803277 hasConcept C2779234561 @default.
- W3009803277 hasConcept C54355233 @default.
- W3009803277 hasConcept C71924100 @default.
- W3009803277 hasConcept C72563966 @default.
- W3009803277 hasConcept C86803240 @default.
- W3009803277 hasConceptScore W3009803277C126322002 @default.
- W3009803277 hasConceptScore W3009803277C131872663 @default.
- W3009803277 hasConceptScore W3009803277C172680121 @default.
- W3009803277 hasConceptScore W3009803277C187212893 @default.
- W3009803277 hasConceptScore W3009803277C203014093 @default.
- W3009803277 hasConceptScore W3009803277C2777575956 @default.
- W3009803277 hasConceptScore W3009803277C2778279030 @default.
- W3009803277 hasConceptScore W3009803277C2778642596 @default.
- W3009803277 hasConceptScore W3009803277C2778780700 @default.
- W3009803277 hasConceptScore W3009803277C2779134260 @default.
- W3009803277 hasConceptScore W3009803277C2779234561 @default.
- W3009803277 hasConceptScore W3009803277C54355233 @default.
- W3009803277 hasConceptScore W3009803277C71924100 @default.
- W3009803277 hasConceptScore W3009803277C72563966 @default.
- W3009803277 hasConceptScore W3009803277C86803240 @default.
- W3009803277 hasIssue "4" @default.
- W3009803277 hasLocation W30098032771 @default.
- W3009803277 hasOpenAccess W3009803277 @default.
- W3009803277 hasPrimaryLocation W30098032771 @default.
- W3009803277 hasRelatedWork W1964203274 @default.
- W3009803277 hasRelatedWork W2017194889 @default.
- W3009803277 hasRelatedWork W2046842812 @default.
- W3009803277 hasRelatedWork W2074469795 @default.
- W3009803277 hasRelatedWork W2151413950 @default.
- W3009803277 hasRelatedWork W2189483303 @default.
- W3009803277 hasRelatedWork W2368136628 @default.
- W3009803277 hasRelatedWork W2541627089 @default.
- W3009803277 hasRelatedWork W3132098153 @default.
- W3009803277 hasRelatedWork W2612005728 @default.
- W3009803277 hasVolume "44" @default.
- W3009803277 isParatext "false" @default.
- W3009803277 isRetracted "false" @default.
- W3009803277 magId "3009803277" @default.
- W3009803277 workType "article" @default.