FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3009805942> ?p ?o ?g. }

• W3009805942 endingPage "108325" @default.
• W3009805942 startingPage "108325" @default.
• W3009805942 abstract "Monocyte infiltration and macrophage polarization are widely considered as pivotal steps for the initiation and progression of atherosclerosis. Previous studies suggested that zanthoxylum piperitum had strong analgesic and anti-inflammatory effects. However, it remains unclear whether zanthoxylum piperitum inhibits inflammation via macrophage function. In the present study, we investigated the effects of xanthoplanine (the total alkaloid extract of zanthoxylum piperitum) on macrophage function. CCK-8 kit was performed to determine cell viability and the preferred concentration of xanthoplanine. We assayed the effects of xanthoplanine on markers of macrophage polarization and inflammation via quantitative PCR and enzyme-linked immunosorbent assay, and measured the production of reactive oxygen species (ROS) by flow cytometry. Immunoblots, co-immunoprecipitation, immunofluorescence and Luciferase activity were performed to investigate the molecular mechanism of STAT signaling pathway in response to xanthoplanine. We found that xanthoplanine (50 and 100 μM) significantly reduced M1 polarization and promoted M2 polarization. The contents of inflammatory cytokines measured by ELISA were markedly decreased in macrophages pretreated with xanthoplanine, compared with those induced by LPS and IFN-γ. In parallel, xanthoplanine alleviated the production of ROS in macrophages induced by LPS and IFN-γ. Moreover, xanthoplanine alleviated STAT5 phosphorylation and blocked STAT5 nuclear translocation without alterations in CrkL expression, subsequently interrupting the interaction between p-STAT5 and CrkL. Likewise, xanthoplanine prominently attenuated the transcription activity of STAT5 induced by LPS and IFN-γ but did not affect the transcription activity of STAT1 and STAT3. Xanthoplanine attenuated M1 phenotypic switch and macrophage inflammation via blocking the formation of CrkL-STAT5 complex." @default.
• W3009805942 created "2020-03-13" @default.
• W3009805942 creator A5025121085 @default.
• W3009805942 creator A5029489135 @default.
• W3009805942 creator A5035295203 @default.
• W3009805942 creator A5036309714 @default.
• W3009805942 creator A5069379096 @default.
• W3009805942 creator A5075889094 @default.
• W3009805942 creator A5084854649 @default.
• W3009805942 date "2020-04-01" @default.
• W3009805942 modified "2023-10-18" @default.
• W3009805942 title "Xanthoplanine attenuates macrophage polarization towards M1 and inflammation response via disruption of CrkL-STAT5 complex" @default.
• W3009805942 cites W1985179791 @default.
• W3009805942 cites W1990844197 @default.
• W3009805942 cites W2001717792 @default.
• W3009805942 cites W2011438792 @default.
• W3009805942 cites W2015141049 @default.
• W3009805942 cites W2024102536 @default.
• W3009805942 cites W2031047943 @default.
• W3009805942 cites W2040143484 @default.
• W3009805942 cites W2050115058 @default.
• W3009805942 cites W2064913753 @default.
• W3009805942 cites W2077792952 @default.
• W3009805942 cites W2091891742 @default.
• W3009805942 cites W2114065448 @default.
• W3009805942 cites W2123303185 @default.
• W3009805942 cites W2160063406 @default.
• W3009805942 cites W2412240036 @default.
• W3009805942 cites W2537619923 @default.
• W3009805942 cites W2587069137 @default.
• W3009805942 cites W2609676491 @default.
• W3009805942 cites W2612921349 @default.
• W3009805942 cites W2781853139 @default.
• W3009805942 cites W2789326640 @default.
• W3009805942 cites W2807241748 @default.
• W3009805942 cites W2885088003 @default.
• W3009805942 cites W2895130115 @default.
• W3009805942 doi "https://doi.org/10.1016/j.abb.2020.108325" @default.
• W3009805942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32142888" @default.
• W3009805942 hasPublicationYear "2020" @default.
• W3009805942 type Work @default.
• W3009805942 sameAs 3009805942 @default.
• W3009805942 citedByCount "8" @default.
• W3009805942 countsByYear W30098059422020 @default.
• W3009805942 countsByYear W30098059422021 @default.
• W3009805942 countsByYear W30098059422022 @default.
• W3009805942 countsByYear W30098059422023 @default.
• W3009805942 crossrefType "journal-article" @default.
• W3009805942 hasAuthorship W3009805942A5025121085 @default.
• W3009805942 hasAuthorship W3009805942A5029489135 @default.
• W3009805942 hasAuthorship W3009805942A5035295203 @default.
• W3009805942 hasAuthorship W3009805942A5036309714 @default.
• W3009805942 hasAuthorship W3009805942A5069379096 @default.
• W3009805942 hasAuthorship W3009805942A5075889094 @default.
• W3009805942 hasAuthorship W3009805942A5084854649 @default.
• W3009805942 hasConcept C153911025 @default.
• W3009805942 hasConcept C185592680 @default.
• W3009805942 hasConcept C202751555 @default.
• W3009805942 hasConcept C203014093 @default.
• W3009805942 hasConcept C2776682551 @default.
• W3009805942 hasConcept C2776914184 @default.
• W3009805942 hasConcept C2777003663 @default.
• W3009805942 hasConcept C2779244956 @default.
• W3009805942 hasConcept C2779391668 @default.
• W3009805942 hasConcept C502942594 @default.
• W3009805942 hasConcept C55493867 @default.
• W3009805942 hasConcept C62478195 @default.
• W3009805942 hasConcept C86803240 @default.
• W3009805942 hasConcept C95444343 @default.
• W3009805942 hasConceptScore W3009805942C153911025 @default.
• W3009805942 hasConceptScore W3009805942C185592680 @default.
• W3009805942 hasConceptScore W3009805942C202751555 @default.
• W3009805942 hasConceptScore W3009805942C203014093 @default.
• W3009805942 hasConceptScore W3009805942C2776682551 @default.
• W3009805942 hasConceptScore W3009805942C2776914184 @default.
• W3009805942 hasConceptScore W3009805942C2777003663 @default.
• W3009805942 hasConceptScore W3009805942C2779244956 @default.
• W3009805942 hasConceptScore W3009805942C2779391668 @default.
• W3009805942 hasConceptScore W3009805942C502942594 @default.
• W3009805942 hasConceptScore W3009805942C55493867 @default.
• W3009805942 hasConceptScore W3009805942C62478195 @default.
• W3009805942 hasConceptScore W3009805942C86803240 @default.
• W3009805942 hasConceptScore W3009805942C95444343 @default.
• W3009805942 hasLocation W30098059421 @default.
• W3009805942 hasLocation W30098059422 @default.
• W3009805942 hasOpenAccess W3009805942 @default.
• W3009805942 hasPrimaryLocation W30098059421 @default.
• W3009805942 hasRelatedWork W2132849630 @default.
• W3009805942 hasRelatedWork W2607964748 @default.
• W3009805942 hasRelatedWork W2617671967 @default.
• W3009805942 hasRelatedWork W2893242193 @default.
• W3009805942 hasRelatedWork W3023903717 @default.
• W3009805942 hasRelatedWork W4210995122 @default.
• W3009805942 hasRelatedWork W4220966087 @default.
• W3009805942 hasRelatedWork W4221033626 @default.
• W3009805942 hasRelatedWork W4303184312 @default.
• W3009805942 hasRelatedWork W3118621835 @default.
• W3009805942 hasVolume "683" @default.

• next